4.8 Article

Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy

Kewei Wang et al.

Summary: In this study, a clustered nanosystem was designed to overcome hypoxic resistance in tumors and enhance chemoimmunotherapy. This system utilized tumor acidity-responsive groups and bioorthogonal click chemistry to form large-sized aggregates in tumor tissue, which then slowly dissociated into ultrasmall nanoparticles for enhanced drug delivery. This system not only addressed hypoxia-induced chemoresistance and enhanced antitumor immune responses but also provided a general drug delivery strategy for improved tumor accumulation and penetration.

ACS NANO (2022)

Article Oncology

Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease

Ellis Tibbs et al.

Summary: Granzyme B (GzmB) is a potent cytotoxic molecule used by cytotoxic T lymphocytes and natural killer cells to kill infected or cancerous cells. Recent studies have shown that GzmB plays a role in tissue development and repair, in addition to cell death. Understanding the function of GzmB in different clinical conditions is important for a comprehensive understanding of the immune system and tissue development.

CANCERS (2022)

Review Biochemistry & Molecular Biology

Beyond target cell death - Granzyme serine proteases in health and disease

Simone Nussing et al.

Summary: Granzymes are small serine proteases stored in and released from cytotoxic T lymphocytes and natural killer cells. They activate signaling pathways and inactivate viral proteins. Besides their pro-apoptotic functions, they also play a role in other biological processes, including immunoregulation.

MOLECULAR ASPECTS OF MEDICINE (2022)

Article Engineering, Biomedical

Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy

Ran Han et al.

Summary: The study demonstrates that downregulation of Sb9 enhances the susceptibility of tumor cells to GrB. Furthermore, a nanocarrier capable of efficiently transporting both GrB and siRNA of Sb9 to cells has been constructed. This nanocarrier has cascade tumor targeting properties and can regulate the tumor microenvironment to effectively restrain tumor progression and metastasis.

BIOMATERIALS (2022)

Article Oncology

SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response

Sofia Ibanez-Molero et al.

Summary: Immunotherapies, including immune checkpoint blockade, have improved cancer patient outcomes, but many fail to develop a durable response. Researchers have identified SERPINB9 as a potential resistance mechanism that prevents tumor cell apoptosis. Overexpression of SERPINB9 is associated with resistance in NSCLC and poor prognosis in melanoma, while rare SERPINB9-positive cancer cells may contribute to reservoirs of resistant cells.

ONCOIMMUNOLOGY (2022)

Article Chemistry, Physical

Ferritin Nanocaged Doxorubicin Potentiates Chemo-Immunotherapy against Hepatocellular Carcinoma via Immunogenic Cell Death

Yang Chen et al.

Summary: This study presents a promising strategy for improving the therapeutic efficacy of liver cancer through the use of H-ferritin nanocages loaded with doxorubicin. The nanocages exhibited potent chemo-immunotherapy effects, promoting cellular uptake, tumor penetration, and immunogenic cell death. The results showed significant tumor growth inhibition and reduced systemic toxicity, as well as a robust antitumor immune response.

SMALL METHODS (2022)

Article Chemistry, Multidisciplinary

Granzyme B Turns Nanoparticle Fluorescence ?On? for Imaging Cytotoxic T Lymphocyte Activity in Vivo

Lingling Xu et al.

Summary: The study developed a near-infrared fluorescence probe Cy5.5-CBT-NPs for noninvasive and sensitive evaluation of cancer immunotherapy efficacy. The probe enabled real-time monitoring and enhancement of cytotoxic T lymphocytes (CTLs) responses against tumor cells.

ACS NANO (2022)

Article Oncology

Breast Cancer Statistics, 2022

Angela N. Giaquinto et al.

Summary: This article provides an update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and mammography screening. It shows that breast cancer incidence rates have increased over the past few decades, driven by localized-stage and hormone receptor-positive disease. However, breast cancer mortality rates have been steadily declining since 1989, although at a slower pace in recent years. Despite lower incidence rates, there remains a racial disparity in breast cancer mortality, with higher rates among Black women compared to White women.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Chemistry, Multidisciplinary

Constructing a nanocage-based universal carrier for delivering TLR- activating nucleic acids to enhance antitumor immunotherapy

Baoli Zhang et al.

Summary: In this study, a rationally designed nanocage-like protein carrier was developed for the effective delivery of TLR-activating nucleic acids. The carrier exhibited significantly improved delivery efficiency, achieving efficient cell uptake, specific lysosomal localization, and enhanced immune activation.

NANO TODAY (2022)

Review Oncology

Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness

Robby Barnestein et al.

Summary: With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of care in cancer management has evolved rapidly. However, immunotherapy is not currently beneficial for all patients. Recent research has found that besides their direct cytotoxic effects on cancer cells, several conventional chemotherapeutic (CT) drugs and agents used in targeted therapies (TT) can also enhance antitumor immunity by promoting the elimination or inactivation of suppressive immune cells.

ONCOIMMUNOLOGY (2022)

Article Engineering, Biomedical

Caspase-cleavable peptide-doxorubicin conjugate in combination with CD47-antagonizing nanocage therapeutics for immune-mediated elimination of colorectal cancer

Na Kyeong Lee et al.

Summary: This study presents a novel combination therapy for the treatment of microsatellite-stable colorectal cancer, utilizing a caspase-cleavable peptide-doxorubicin conjugate (MPD-1) and CD47 antagonist nanocage. The combination therapy effectively induced immunogenic cell death in tumor cells, enhanced T cell infiltration, and elicited a potent immune response against MSS CRC, leading to tumor growth inhibition and tumor-specific T cell activation.

BIOMATERIALS (2021)

Review Nanoscience & Nanotechnology

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari et al.

Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.

NATURE REVIEWS MATERIALS (2021)

Article Chemistry, Multidisciplinary

Bioengineered Dual-Targeting Protein Nanocage for Stereoscopically Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy

Zhuoran Wang et al.

Summary: The Am-PNCage is a novel protein nanocarrier with dual-targeting properties, allowing for effective drug loading and promoting drug penetration and accumulation in tumors in vivo.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Visible-Light-Triggered Prodrug Nanoparticles Combine Chemotherapy and Photodynamic Therapy to Potentiate Checkpoint Blockade Cancer Immunotherapy

Jiwoong Choi et al.

Summary: Immune checkpoint blockade is a promising approach for cancer immunotherapy, but many patients do not respond due to the immunosuppressive tumor microenvironment. This study proposes visible-light-triggered prodrug nanoparticles (LT-NPs) to reverse the immunosuppressive tumor microenvironment and enhance checkpoint blockade immunotherapy, showing promising results in tumor models.

ACS NANO (2021)

Article Engineering, Biomedical

Biodegradable cascade nanocatalysts enable tumor-microenvironment remodeling for controllable CO release and targeted/synergistic cancer nanotherapy

Jianrong Wu et al.

Summary: This study presents a strategy for tumor microenvironment remodeling and sustained release of CO gas through engineered cascade biodegradable nanocatalyst, leading to enhanced therapeutic efficacy.

BIOMATERIALS (2021)

Review Cell Biology

Microenvironmental control of cell fate decisions in mammary gland development and cancer

Gat Rauner et al.

Summary: Cell fate decisions in the mammary gland are tightly controlled by the microenvironment, specifically by the extracellular matrix, immune microenvironment, and hormones. Pathological changes in the microenvironment can alter cell fates, leading to malignancy. This review highlights how these elements converge to promote DNA damage and affect mammary cell fate.

DEVELOPMENTAL CELL (2021)

Article Chemistry, Multidisciplinary

Overcoming Chemoimmunotherapy-Induced Immunosuppression by Assemblable and Depot Forming Immune Modulating Nanosuspension

Seung Mo Jin et al.

Summary: A novel immune modulating suspension containing inducers of cell death and supra-adjuvants can effectively increase cytotoxic T lymphocytes and alleviate immune suppression in the tumor microenvironment, leading to enhanced T cell infiltration and inhibition of tumor metastasis. This approach shows promise in increasing the response rate of immune checkpoint blockade therapy, presenting a new nanotheranostic strategy in cancer immunotherapy.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

Xuexiang Han et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Biochemistry & Molecular Biology

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy

Liwei Jiang et al.

Article Medicine, Research & Experimental

Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis

Yinlong Zhang et al.

THERANOSTICS (2017)

Review Biochemistry & Molecular Biology

Natural and therapy-induced immunosurveillance in breast cancer

Guido Kroemer et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

JP Medema et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)