Novel pyrazolothienopyridinones as potential GABAA receptor modulators

The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA(A) receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds. [GRAPHICS] .

Automated summary

The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA(A) receptor modulators was achieved through two different synthetic strategies, resulting in a set of 8 target compounds.