Journal
MOLECULES
Volume 28, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/molecules28083395
Keywords
naproxen derivative; resveratrol; synergistic; anti-inflammatory; mechanism
Ask authors/readers for more resources
A novel naproxen derivative containing cinnamic acid (NDC) was synthesized and used in combination with resveratrol to improve anti-inflammatory activity and safety. The combination showed synergistic anti-inflammatory efficacy in RAW264.7 macrophage cells without detectable side effects.
Naproxen is widely used for anti-inflammatory treatment but it can lead to serious side effects. To improve the anti-inflammatory activity and safety, a novel naproxen derivative containing cinnamic acid (NDC) was synthesized and used in combination with resveratrol. The results showed that the combination of NDC and resveratrol at different ratios have a synergistic anti-inflammatory efficacy in RAW264.7 macrophage cells. It was indicated that the combination of NDC and resveratrol at a ratio of 2:1 significantly inhibited the expression of carbon monoxide (NO), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), induced nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2) and reactive oxygen species (ROS) without detectable side effects on cell viability. Further studies revealed that these anti-inflammatory effects were mediated by the activation of nuclear factor kappa-B (NF-kappa B), mitogen-activated protein kinase (MAPK) and phosphoinositide-3 kinase (PI3K)/protein kinase B (Akt) signaling pathways, respectively. Taken together, these results highlighted the synergistic NDC and resveratrol anti-inflammatory activity that could be further explored as a strategy for the treatment of inflammatory disease with an improved safety profile.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available