Recent Advances in In Vitro and In Vivo Studies of Antioxidant, ACE-Inhibitory and Anti-Inflammatory Peptides from Legume Protein Hydrolysates

Consumption of legumes has been shown to enhance health and lower the risk of cardiovascular disease and specific types of cancer. ACE inhibitors, antioxidants, and synthetic anti-inflammatories are widely used today; however, they have several undesirable side effects. Thus, researchers have focused on finding ACE inhibitors, antioxidant, and anti-inflammatory peptides from natural sources, such as legumes. Recently, in vitro and in vivo research has shown the bioactive peptides generated from legume protein hydrolysates, such as antioxidant, anti-hypertensive, anticancer, anti-proliferative, anti-inflammatory, etc., in the context of different disease mitigation. Therefore, this review aims to describe the recent advances in in vitro and in vivo studies of antioxidant, anti-hypertensive and anti-inflammatory peptides isolated from legume-derived protein hydrolysates. The results indicated that antioxidant legumes peptides are characterized by short-chain sequence amino acids and possess anti-hypertensive properties by reducing systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR).

Automated summary

Consumption of legumes has been proven to enhance health and reduce the risk of cardiovascular disease and certain types of cancer. Researchers have focused on finding natural sources of ACE inhibitors, antioxidants, and anti-inflammatory peptides, such as legumes. Recent studies have shown that bioactive peptides derived from legume protein hydrolysates have various beneficial effects, including antioxidant, anti-hypertensive, anticancer, anti-proliferative, and anti-inflammatory properties. This review aims to describe the recent advances in in vitro and in vivo studies on antioxidant, anti-hypertensive, and anti-inflammatory peptides isolated from legume-derived protein hydrolysates. The results indicate that antioxidant legume peptides possess short-chain amino acid sequences and have anti-hypertensive properties by reducing systolic blood pressure in hypertensive rats.