Journal
MOLECULES
Volume 28, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/molecules28083326
Keywords
crown ether; benzoxazole; unnatural amino acids; recognition; palladium; fluorimetric chemosensors
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A series of highly emissive heterocyclic alanines bearing a benzo[d]oxazolyl unit functionalized with different heterocyclic pi-spacers and (aza)crown ether moieties were synthesized. These compounds were characterized and evaluated as fluorimetric chemosensors. The sensory properties of these unnatural amino acids towards Pd2+ and Fe3+ were fine-tuned by the different crown ether binding moieties and the electronic nature of the pi-bridge, as observed by spectrofluorimetric titrations.
Unnatural amino acids with enhanced properties, such as increased complexing ability and luminescence, are considered to be highly attractive building blocks for bioinspired frameworks, such as probes for biomolecule dynamics, sensitive fluorescent chemosensors, and peptides for molecular imaging, among others. Therefore, a novel series of highly emissive heterocyclic alanines bearing a benzo[d]oxazolyl unit functionalized with different heterocyclic pi-spacers and (aza)crown ether moieties was synthesized. The new compounds were completely characterized using the usual spectroscopic techniques and evaluated as fluorimetric chemosensors in acetonitrile and aqueous mixtures in the presence of various alkaline, alkaline-earth, and transition metal ions. The different crown ether binding moieties as well as the electronic nature of the pi-bridge allowed for fine tuning of the sensory properties of these unnatural amino acids towards Pd2+ and Fe3+, as seen by spectrofluorimetric titrations.
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