Journal
MOLECULES
Volume 28, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/molecules28052161
Keywords
carbon nanotubes; functionalization; silanization; click chemistry; SPAAC; nanohybrids; nano biosensor
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In this study, we propose a method to functionalize silanized single-walled carbon nanotubes (SWNTs) using copper-free click chemistry for the assembly of inorganic and biological nanohybrids. Silanization and strain-promoted azide-alkyne cycloaddition reactions (SPACC) were employed for SWNT functionalization. The functionalized SWNTs were successfully immobilized onto patterned substrates through dielectrophoresis (DEP). The strategy demonstrated general applicability for the functionalization of SWNTs with metal nanoparticles, fluorescent dyes, and biomolecules.
Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide-alkyne cycloaddition reactions (SPACC). This was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and Fourier transform infra-red spectroscopy. Silane-azide-functionalized SWNTs were immobilized from solution onto patterned substrates through dielectrophoresis (DEP). We demonstrate the general applicability of our strategy for the functionalization of SWNTs with metal nanoparticles (gold nanoparticles), fluorescent dyes (Alexa Fluor 647) and biomolecules (aptamers). In this regard, dopamine-binding aptamers were conjugated to the functionalized SWNTs to perform real-time detection of dopamine at different concentrations. Additionally, the chemical route is shown to selectively functionalize individual nanotubes grown on the surface of silicon substrates, contributing towards future nano electronic device applications.
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