4.6 Article

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Synthesis of piperine analogues as AChE and BChE inhibitors for the treatment of Alzheimer?s disease

Suwichada Jaipea et al.

Summary: The alkaloid piperine 1 extracted from the black pepper plant (Piper nigrum L.) was converted to piperine amide derivatives (3a-3z) through condensation with various piperazine derivatives and secondary amines. These synthesized compounds were evaluated for their antioxidant and inhibition activities against AChE and BChE, which are important targets for Alzheimer’s disease therapy. Most of the compounds showed good antioxidant behavior and potent inhibition of AChE and BChE activities. In particular, compound 3c exhibited the highest AChE inhibition, while compounds 3v, 3x, and 3z showed better BChE inhibitory activities than galantamine. Docking studies confirmed their good binding energies to the target enzymes, suggesting their potential as anti-Alzheimer's drugs.

PHYTOCHEMISTRY LETTERS (2023)

Article Biochemistry & Molecular Biology

Amorphous Inclusion Complexes: Molecular Interactions of Hesperidin and Hesperetin with HP-B-CD and Their Biological Effects

Kamil Wdowiak et al.

Summary: This study aimed to obtain hesperidin and hesperetin systems with HP-beta-CD, and evaluated their physicochemical properties and biological activities. The results showed significant improvement in solubility, permeability, and inhibitory activity, indicating the potential of HP-beta-CD as a carrier to enhance the biological activity and bioavailability of hesperidin and hesperetin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Pharmacology & Pharmacy

Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance

Arun Butreddy et al.

Summary: This study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine. The results show that specific polymer combinations can delay nucleation induction time and enhance dissolution performance, potentially improving oral absorption.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Food Science & Technology

Preparation and characterization of curcumin/β-cyclodextrin nanoparticles by nanoprecipitation to improve the stability and bioavailability of curcumin

Longwei Jiang et al.

Summary: This study successfully synthesized curcumin/beta-cyclodextrin inclusion complex nanoparticles using flexible and efficient nanoprecipitation method. The encapsulation efficiency reached over 70% at a ratio of 1:2 or 1:1, and the particle size was around 200 nm. The results from various characterization techniques confirmed the construction of nanoparticles and their stability. Encapsulation of curcumin improved its bioavailability, and the nanoparticles exhibited excellent physicochemical stability. Nanoprecipitation shows promise in synthesizing CD-based nanoparticles with enhanced stability and bioavailability.

LWT-FOOD SCIENCE AND TECHNOLOGY (2022)

Article Neurosciences

Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

Sebnem Erfen et al.

Summary: This study aimed to investigate the therapeutic and preventive effects of piperine, curcumin, and their combination on astrocyte cells. The results showed that these compounds significantly increased cell viability, decreased apoptosis and necrosis, and reduced cytokine release in aluminum-induced damage.

NEUROTOXICITY RESEARCH (2022)

Article Pharmacology & Pharmacy

Formulation development of curcumin-piperine solid dispersion via hot-melt extrusion

Abdulmajeed A. Althobaiti et al.

Summary: Curcumin, derived from turmeric, has various biological activities. This study successfully prepared curcumin-piperine solid dispersion using the hot-melt extrusion technique, resulting in significant improvement in the release profile of curcumin.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Article Pharmacology & Pharmacy

Enteric Polymer-Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation

Yuling Qin et al.

Summary: In this study, the solubilization and inhibitory effects on nintedanib in the presence of enteric polymers were investigated. The results showed that Eudragit L100 polymer provided the best solubilization and inhibitory effects on nintedanib, and when formulated into amorphous solid dispersions (ASDs), its relative bioavailability increased significantly.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization

Aasma Akram et al.

Summary: This study aims to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, through solid dispersion techniques. Different polymer carriers were used at varying concentrations to prepare solid dispersion formulations, with the optimized ternary system showing the highest increase in solubility and dissolution rate.

PHARMACEUTICS (2022)

Review Chemistry, Medicinal

Piperine: A review of its biological effects

Iahtisham-Ul Haq et al.

Summary: Black pepper, as a commonly used medicinal plant, has various pharmacological effects and health-promoting properties, making it a potential therapeutic agent for several diseases.

PHYTOTHERAPY RESEARCH (2021)

Review Biochemistry & Molecular Biology

The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer's Disease Pathogenesis

Jacek Jasiecki et al.

Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure or prevention despite over a century of research. The presence of high levels of Aβ plaques and brain iron, associated with neuroinflammatory changes, may accelerate cognitive decline in AD. The exact biochemical mechanism explaining the prevention of cognitive impairment in some individuals with high Aβ deposits remains unknown.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Enhanced Anticancer Response of Curcumin- and Piperine-Loaded Lignin-g-p (NIPAM-co-DMAEMA) Gold Nanogels against U-251 MG Glioblastoma Multiforme

Bilal Javed et al.

Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.

BIOMEDICINES (2021)

Review Pharmacology & Pharmacy

Recent Technologies for Amorphization of Poorly Water-Soluble Drugs

Do-Hyun Kim et al.

Summary: Amorphization technology is a focus in the pharmaceutical industry to enhance the solubility and bioavailability of drugs. Traditional carriers for amorphous drugs have limitations, leading to the investigation of novel carriers and preparation methods to improve drug loading and amorphization. Recent advancements in amorphization technologies, such as co-amorphous systems and mesoporous particle-based techniques, are discussed for their characteristics and commercial potential.

PHARMACEUTICS (2021)

Review Chemistry, Medicinal

Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

Przemyslaw Liczbinski et al.

PHYTOTHERAPY RESEARCH (2020)

Article Pharmacology & Pharmacy

Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers

Luning Dong et al.

PHARMACEUTICS (2020)

Article Chemistry, Medicinal

Synergistic Effect of Self-Assembled Curcumin and Piperine Co-Loaded Human Serum Albumin Nanoparticles on Suppressing Cancer Cells

Hossein Abolhassani et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

Review Chemistry, Multidisciplinary

In vitro dissolution study on inclusion complex of piperine with ethylenediamine-β-cyclodextrin

Kai Liu et al.

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Enhancing Curcumin Oral Bioavailability Through Nanoformulations

Vinod S. Ipar et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2019)

Review Biochemistry & Molecular Biology

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Anju Singh et al.

MOLECULES (2019)

Article Plant Sciences

Carbonate-β-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization

B. Garrido et al.

JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION (2019)

Review Nutrition & Dietetics

Dietary Curcumin: Correlation between Bioavailability and Health Potential

Michele Dei Cas et al.

NUTRIENTS (2019)

Review Chemistry, Multidisciplinary

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Zorica Stojanovic-Radic et al.

APPLIED SCIENCES-BASEL (2019)

Review Food Science & Technology

Piperine-The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations

Leila Gorgani et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2017)

Review Plant Sciences

Curcumin, a Compound from Natural Sources, a True Scientific Challenge - A Review

Zorka Stanic

PLANT FOODS FOR HUMAN NUTRITION (2017)

Article Chemistry, Medicinal

Enhanced solubility of piperine using hydrophilic carrier-based potent solid dispersion systems

Kathavarayan Thenmozhi et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

Review Pharmacology & Pharmacy

Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century

Roshan V. Tiwari et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

Article Chemistry, Multidisciplinary

Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP

Shufan Ge et al.

PHARMACEUTICAL RESEARCH (2016)

Article Chemistry, Multidisciplinary

Strength of Drug-Polymer Interactions: Implications for Crystallization in Dispersions

Pinal Mistry et al.

CRYSTAL GROWTH & DESIGN (2016)

Article Medicine, Research & Experimental

Molecular Dynamics and Physical Stability of Amorphous Nimesulide Drug and Its Binary Drug-Polymer Systems

J. Knapik et al.

MOLECULAR PHARMACEUTICS (2016)

Review Biochemistry & Molecular Biology

Curcumin and Health

Mario Pulido-Moran et al.

MOLECULES (2016)

Article Pharmacology & Pharmacy

Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System

Liandong Hu et al.

AAPS PHARMSCITECH (2015)

Review Integrative & Complementary Medicine

Curcumin, a golden spice with a low bioavailability

Angelo Siviero et al.

JOURNAL OF HERBAL MEDICINE (2015)

Article Instruments & Instrumentation

Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin

Alex E. Grill et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2014)

Article Medicine, Research & Experimental

Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases via Induction of Supersaturation

Yan Yan Yeap et al.

MOLECULAR PHARMACEUTICS (2013)

Article Medicine, Research & Experimental

Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability

Scott L. Childs et al.

MOLECULAR PHARMACEUTICS (2013)

Article Agriculture, Multidisciplinary

Curcumin Nanoparticles Improve the Physicochemical Properties of Curcumin and Effectively Enhance Its Antioxidant and Antihepatoma Activities

Feng-Lin Yen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

Article Medicine, Research & Experimental

Amorphous Compositions Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole

James C. DiNunzio et al.

MOLECULAR PHARMACEUTICS (2008)