4.6 Review

Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Hydrolysable tannins change physicochemical parameters of lipid nano-vesicles and reduce DPPH radical - Experimental studies and quantum chemical analysis

Szymon Sekowski et al.

Summary: This study investigated the interactions between two hydrolysable tannins and liposomes, revealing that the more flexible tannins can decrease membrane viscosity more effectively and increase the zeta potential values. Both tannins interacted with liposomes through P=O groups of head of phospholipids and their hydrophobic regions. Additionally, the tannins were found to neutralize DPPH free radicals with a stoichiometry of 1:1.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2022)

Review Biotechnology & Applied Microbiology

Clinical application of nano-targeting for enhancing chemotherapeutic efficacy and safety in cancer management

Matthew C. Phillips et al.

Summary: This review focuses on the safety and efficacy of nanoformulated chemotherapeutic agents in clinical trials, with a particular emphasis on anthracyclines, taxanes, and platinum compounds. Nano-based drug-delivery systems have the potential to improve efficacy and reduce adverse effects by targeting chemotherapy.

NANOMEDICINE (2022)

Review Pharmacology & Pharmacy

Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases

Ikuko Kimura et al.

Summary: This review summarizes the potential prophylactic and therapeutic effects of bamboo leaf extract and its constituents against infectious, inflammatory, cardiovascular, metabolic, and neurological/neuropsychiatric diseases, including the mechanisms and effects of some constituent compounds, as well as the possible interaction with probiotics.

PHARMACOLOGY & THERAPEUTICS (2022)

Article Chemistry, Multidisciplinary

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

Wen Li et al.

Summary: Aerobic glycolysis, also known as the Warburg effect, is a key characteristic of cancer cell metabolism. GAPDH, an important enzyme in glycolysis, is a potential therapeutic target for cancer treatment. PGG has been identified as a novel reversible inhibitor of GAPDH, suggesting potential for future therapeutic applications.

ACTA PHARMACOLOGICA SINICA (2022)

Article Pharmacology & Pharmacy

Pentagalloyl Glucose, a Major Compound in Mango Seed Kernel, Exhibits Distinct Gastroprotective Effects in Indomethacin-Induced Gastropathy in Rats via Modulating the NO/eNOS/iNOS Signaling Pathway

Mona F. Mahmoud et al.

Summary: This study found that pentagalloyl glucose (PGG) has a protective effect against gastric ulcers, possibly by increasing mucus production, scavenging free radicals, reducing inflammation, and attenuating the NO/NOS signaling.

FRONTIERS IN PHARMACOLOGY (2022)

Review Cell Biology

Cell cycle control in cancer

Helen K. Matthews et al.

Summary: This review highlights the importance of cell cycle regulation in preventing genetic errors and cell proliferation, and how disruption of these mechanisms is associated with cancer development. Cancer arises from continuous cell division and evasion of cell cycle control mechanisms.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Plant Sciences

Potent antiviral activity of the extract of Elaeocarpus sylvestris against influenza A virus in vitro and in vivo

Yong-Hyun Joo et al.

Summary: The study found that the extract of Elaeocarpus sylvestris has strong antiviral activity against influenza A virus infection, which could lead to the development of new plant-based medicine to treat influenza virus infection.

PHYTOMEDICINE (2022)

Article Cell Biology

Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H2AX, CHK2 and p53

Ji-Hyun Kim et al.

Summary: The apoptotic mechanism of PGG in cisplatin-resistant lung cancer cells was investigated. PGG was found to induce apoptosis through upregulation of DNA damage proteins, such as γ-H(2)AX, pCHK2, and p53.

CELLS (2022)

Article Biochemistry & Molecular Biology

A Novel Strategy for Unveiling Spatial Distribution Pattern of Gallotannins in Paeonia rockii and Paeonia ostii Based on LC-QTRAP-MS

Zhangzhen Bai et al.

Summary: In this study, an LC-MS/MS strategy was developed to investigate the spatial distribution pattern of GTs in Paeonia rockii and P. ostii. It was found that GTs exhibited diverse distribution patterns in different tissues.

METABOLITES (2022)

Review Biochemistry & Molecular Biology

The Molecular Mechanisms of Actions, Effects, and Clinical Implications of PARP Inhibitors in Epithelial Ovarian Cancers: A Systematic Review

Chien-Hui Lau et al.

Summary: Ovarian cancer is the deadliest gynecologic malignancy in the United States. Patients with ovarian cancer often have defects in DNA repair pathways, particularly in homologous recombination (HR), which is linked to mutations in BRCA1 or BRCA2. PARP inhibitors have emerged as a unique strategy to treat HR-deficient cancers, but further research is needed to fully understand their mechanisms and effectiveness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Plant Sciences

Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo

Cai-Wen Fan et al.

Summary: This study demonstrated that PGG can inhibit proliferation, induce apoptosis and autophagy, and decrease metastatic capacity of NPC cells. Mechanistically, PGG exerts its effects through the p38 MAPK/mTOR and Wnt/beta-catenin pathways, providing evidence for PGG as a potential therapeutic option for NPC.

PHYTOMEDICINE (2022)

Article Chemistry, Medicinal

Pentagalloyl Glucose and Cisplatin Combination Treatment Exhibits a Synergistic Anticancer Effect in 2D and 3D Models of Head and Neck Carcinoma

Jiraporn Kantapan et al.

Summary: This study demonstrates that the combination of pentagalloyl glucose (PGG) and cisplatin enhances their anti-tumor activities on cisplatin-resistant head and neck squamous cell carcinoma (HNSCC) cell lines. The combination treatment inhibits cell viability, promotes apoptosis, and inhibits cell migration more effectively than monotherapy. These effects may be related to the reduced expression of phosphorylated STAT3 and phosphorylated Akt mediated by PGG.

PHARMACEUTICALS (2022)

Article Oncology

Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy

Jie Zeng et al.

Summary: The study reveals that Pentagalloylglucose (PGG) disrupts the PALB2-BRCA2 protein-protein interaction, inhibiting homologous recombination repair and suppressing tumor cell proliferation and survival, which shows potential value in cancer treatment.

CANCER LETTERS (2022)

Article Pharmacology & Pharmacy

Anti-metastatic effects of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in colorectal cancer: Regulation of cathepsin B-mediated extracellular matrix dynamics and epithelial-to-mesenchymal transition

Huihai Yang et al.

Summary: This study found that the natural gallotannin PGG has anti-tumor effects on colon cancer cells and inhibits cell proliferation, colony formation, motility, and migration. It also demonstrated that PGG suppresses liver and lung metastasis in mouse models and regulates immune cell populations and cytokine levels. These findings suggest that PGG has the potential to be developed as an anti-metastatic agent for metastatic CRC.

PHARMACOLOGICAL RESEARCH (2022)

Article Cell Biology

1,2,3,4,6-Penta-O-galloyl-β-D-glucose Inhibits CD44v3, a cancer stem cell marker, by regulating its transcription factor, in human pancreatic cancer cell line

Eun-Young Kim et al.

Summary: This study evaluated the effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) on CD44 markers in pancreatic cancer cells and found that PGG inhibits the proliferation, clonogenic activity, adhesion, and migration of cancer cells. PGG also downregulates CSC regulatory factors and induces CD44v3 ubiquitination.

ANIMAL CELLS AND SYSTEMS (2022)

Article Biochemistry & Molecular Biology

Isolation of phenolic acids and tannin acids from Mangifera indica L. kernels as inhibitors of lipid accumulation in 3T3-L1 cells

Takahiro Fujimaki et al.

Summary: This study identified antiobesity compounds from mango kernels that inhibit lipid formation and downregulate adipogenic transcription factors, suggesting their therapeutic potential against obesity.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2022)

Article Medicine, Research & Experimental

Combating multidrug resistance and metastasis of breast cancer by endoplasmic reticulum stress and cell-nucleus penetration enhanced immunochemotherapy

Weixi Jiang et al.

Summary: This study developed a theranostic nanocomposite using silver nanoparticles and peptide-functionalized doxorubicin to induce organelle-mediated immunochemotherapy and drug efflux protein inhibition in drug-resistant breast cancer cells. The results showed enhanced cytotoxicity, stimulated immunogenic cell death, and potential for reversing tumor multidrug resistance and metastasis at the subcellular level.

THERANOSTICS (2022)

Review Oncology

Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms

Gang Li et al.

Summary: This article discusses the importance of natural products from plants and associated microorganisms in the discovery of anticancer drugs, and introduces the application of artificial intelligence techniques in this field.

TRENDS IN CANCER (2022)

Article Chemistry, Applied

Inhibitory effects and molecular mechanisms of pentagalloyl glucose in combination with 5-FU on aggressive phenotypes of HepG2 cells

Xiao-Qing Ding et al.

Summary: The study demonstrated that the combination of PGG and 5-FU had synergistic effects on inhibiting proliferation and inducing apoptosis in HepG2 cells, potentially reversing resistance to 5-FU. This combination also led to G1 phase arrest and downregulation of MDR1 and LRP1, indicating its potential as a therapeutic strategy for liver cancer.

NATURAL PRODUCT RESEARCH (2021)

Review Pharmacology & Pharmacy

Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance

Jing-Quan Wang et al.

Summary: ABC transporters mediate the translocation of structurally and mechanistically distinct substrates against steep concentration gradients using ATP energy. The ABCC subfamily is the largest in humans, with 13 members, including 9 multidrug resistance proteins that can extrude chemotherapeutic agents from tumor cells. Additionally, MRPs are also involved in the efflux of physiologically important organic anions and are potential targets for overcoming cancer multidrug resistance.

DRUG RESISTANCE UPDATES (2021)

Article Pharmacology & Pharmacy

Reversal of elastase-induced abdominal aortic aneurysm following the delivery of nanoparticle-based pentagalloyl glucose (PGG) is associated with reduced inflammatory and immune markers

Saphala Dhital et al.

Summary: The study confirmed the hypothesis of using PGG-NPs therapy to reverse abdominal aortic aneurysm, showing that the treatment can suppress inflammation and restore arterial homeostasis, potentially offering an effective option for advanced stage aneurysms.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Plant Sciences

The traditional and modern uses of Selaginella tamariscina (P.Beauv.) Spring, in medicine and cosmetic: Applications and bioactive ingredients

Christian Bailly

Summary: Selaginella tamariscina extracts have been used traditionally in Asia for various disease treatments. They exhibit a range of pharmacological effects beneficial for metabolic disorders, inflammatory diseases, and cancers. The main bioactive natural products responsible for these effects are biflavonoids and phenolic compounds.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells

Jinzhi Tong et al.

Summary: The study demonstrated that PGG inhibits the JAK2/STAT3 cascade by activating Nrf2/HO-1 signaling, which in turn suppresses ROS generation and inflammatory cytokines induced by AGE. Moreover, the involvement of Nrf2 in blocking the JAK2/STAT3 cascade by PGG was confirmed using the Nrf2 transcriptional inhibitor ML385.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

Rapid screening and separation of active compounds against α-amylase from Toona sinensis by ligand fishing and high-speed counter-current chromatography

Jing Meng et al.

Summary: An efficient method combining ligand fishing and high-speed counter-current chromatography was established to screen, enrich, and separate active components with α-amylase inhibitory activity from Tornio sinensis. The potential active compound 1,2,3,4,6-penta-O-galloyl-beta-D-glucose was identified to have higher activity against α-amylase compared to a non-target compound. This study provides a new approach for the study of natural active components.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Multidisciplinary Sciences

Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells

Patricia Mendonca et al.

Summary: The study found that PGG has anti-cancer effects on TNF-alpha activated TNBC cell lines by reducing cell proliferation, inhibiting GRO-alpha release, and inducing apoptosis through increasing TNF and TNF family receptor expression.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection

Rui Hong Chen et al.

Summary: The study revealed that PGG may effectively combat COVID-19 by blocking the fusion of SARS-CoV-2 spike RBD to hACE2 receptors, showing potential antiviral properties and demonstrating high safety in animal experiments.

FRONTIERS IN PHARMACOLOGY (2021)

Review Immunology

Natural Polyphenols as Targeted Modulators in Colon Cancer: Molecular Mechanisms and Applications

Jing Long et al.

Summary: Natural polyphenols, valued for their anti-inflammatory and antioxidant properties, have shown to play a key role in the prevention and treatment of colon cancer by maintaining a balance between gut microbes and hosts.

FRONTIERS IN IMMUNOLOGY (2021)

Article Endocrinology & Metabolism

Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism

Xiaozhuo Chen et al.

Summary: The natural compound alpha-PGG and its synthetic derivative 6Cl-TGQ were found to suppress glucose uptake in beta-cells, leading to decreased glycolysis and ATP synthesis, ultimately resulting in reduced insulin secretion. While these compounds exhibit insulin-like effects in peripheral tissues, they do not act through the insulin receptor in islets.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

Review Oncology

Epithelial to Mesenchymal Transition: Key Regulator of Pancreatic Ductal Adenocarcinoma Progression and Chemoresistance

Kostas Palamaris et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by aggressive behavior and resistance to chemotherapy, with emerging evidence pointing to epithelial to mesenchymal transition (EMT) as a key driver of disease progression and drug resistance. EMT allows cancer cells to transition to a more mesenchymal state, contributing to tumor dissemination and chemoresistance in PDAC.

CANCERS (2021)

Review Biochemistry & Molecular Biology

A Systematic Review and Meta-Analysis of the Effect of Pentagalloyl Glucose Administration on Aortic Expansion in Animal Models

Jonathan Golledge et al.

Summary: The research aimed to investigate the effect of pentagalloyl glucose (PGG) on aortic expansion in animal models of abdominal aortic aneurysm (AAA). The findings suggest that PGG significantly reduced aortic expansion in certain forms, but the studies had a high risk of bias.

BIOMEDICINES (2021)

Review Oncology

Angiogenesis as a hallmark of solid tumors-clinical perspectives

Jamal Majidpoor et al.

Summary: Angiogenesis is a crucial step in tumorigenesis, with abnormal tumor vasculature leading to hypoxia and acidity in the tumor microenvironment, enhancing tumor aggression. High interstitial fluid pressure can act as a barrier for drug delivery, contributing to tumor resistance to therapy. Combination of anti-angiogenesis therapy with other modalities is a promising strategy for advanced cancers.

CELLULAR ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

Md. Ataur Rahman et al.

Summary: Bioactive plant derived compounds play an important role in therapeutic applications, particularly in targeting autophagy and apoptosis pathways for anticancer effects. Pharmacological targeting of these pathways using phytochemicals presents a promising strategy in cancer treatment, although challenges remain in the development of phytochemical-based anticancer drugs.

FRONTIERS IN PHARMACOLOGY (2021)

Review Oncology

The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance

Kalyani Patil et al.

Summary: This review delves into the characteristics of pancreatic cancer stem cells, the mechanisms of treatment failure, and the increasingly popular natural agents targeting stem cells. Understanding the molecular and functional features of stem cells' resistance to chemotherapy in pancreatic cancer presents an opportunity for treatment.

CANCER AND METASTASIS REVIEWS (2021)

Article Geriatrics & Gerontology

Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans

Xiaoying Zhang et al.

Summary: The study demonstrated that PGG has significant immunomodulatory effects, inhibiting the secretion of inflammatory factors and enhancing immunomodulation in C. elegans through multiple signaling pathways. The findings suggest the potential of PGG to be developed into novel immunomodulatory nutraceuticals.

EXPERIMENTAL GERONTOLOGY (2021)

Article Biochemistry & Molecular Biology

Gallotannin from Bouea macrophylla Seed Extract Suppresses Cancer Stem-like Cells and Radiosensitizes Head and Neck Cancer

Jiraporn Kantapan et al.

Summary: The study demonstrated that the extract from Bouea macrophylla seed and its bioactive compound, pentagalloyl glucose, could suppress cancer stem cell-like phenotypes and increase radiosensitivity in head and neck squamous cell carcinoma cell lines. Pretreatment with these compounds enhanced IR-induced DNA damage and radiation-induced cell death, while attenuating stemness-like properties. This suggests a potential novel strategy for improving therapeutic efficacy for head and neck cancer patients using natural products.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Food Science & Technology

Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review

Ayesha Nasir et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Review Biotechnology & Applied Microbiology

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

Haroon Khan et al.

BIOTECHNOLOGY ADVANCES (2020)

Article Biochemistry & Molecular Biology

Interaction of polyphenols with model membranes: Putative implications to mouthfeel perception

Ana Reis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Article Biochemistry & Molecular Biology

Identification of Vaccinia-H1 Related Phosphatase as an Anticancer Target for 1,2,3,4,6-O-Pentagalloylglucose

Sun-Young Yoon et al.

CHEMISTRY & BIODIVERSITY (2020)

Article Integrative & Complementary Medicine

Intra-Pancreatic Insulin Nourishes Cancer Cells: Do Insulin-Receptor Antagonists such as PGG and EGCG Play a Role?

Lijuan Hu et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2020)

Article Integrative & Complementary Medicine

Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway

Jiraporn Kantapan et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Oncology

Transcription Factors in Cancer Development and Therapy

Kanchan Vishnoi et al.

CANCERS (2020)

Article Integrative & Complementary Medicine

Pentagalloylglucose, isolated from the leaf extract ofAnacardium occidentaleL., could elicit rapid and selective cytotoxicity in cancer cells

Bamigboye J. Taiwo et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Medicine, Research & Experimental

In vitro study of anti-ER positive breast cancer effect and mechanism of 1,2, 3,4-6-pentyl-O-galloyl-beta-D-glucose (PGG)

Qiu Xiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Biotechnology & Applied Microbiology

Mechanisms of drug resistance in acute myeloid leukemia

Jing Zhang et al.

ONCOTARGETS AND THERAPY (2019)

Review Biochemistry & Molecular Biology

Markers of pancreatic cancer stem cells and their clinical and therapeutic implications

Arkadiusz Gzil et al.

MOLECULAR BIOLOGY REPORTS (2019)

Review Oncology

Exosomes in Cancer Radioresistance

Jie Ni et al.

FRONTIERS IN ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

Penta-1,2,3,4,6-O-Galloyl-β-d-Glucose Inhibits UVB-Induced Photoaging by Targeting PAK1 and JNK1

Ji-An Kim et al.

ANTIOXIDANTS (2019)

Review Oncology

Contribution of Angiogenesis to Inflammation and Cancer

Dolores Aguilar-Cazares et al.

FRONTIERS IN ONCOLOGY (2019)

Article Integrative & Complementary Medicine

β-Pentagalloyl-Glucose Sabotages Pancreatic Cancer Cells and Ameliorates Cachexia in Tumor-Bearing Mice

Jing Yang et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2019)

Article Chemistry, Medicinal

1,2,3,4,6-Penta-O-galloyl-β-D-glucose suppresses colon cancer through induction of tumor suppressor

Sang Hee Kawk et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Pathology

Epithelial Mesenchymal Transition in Tumor Metastasis

Vivek Mittal

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

Review Oncology

Lysosomes contribute to radioresistance in cancer

Xin Zhang et al.

CANCER LETTERS (2018)

Review Food Science & Technology

Resveratrol as an anti-cancer agent: A review

Abdur Rauf et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2018)

Review Food Science & Technology

Pentagalloylglucose (PGG): A valuable phenolic compound with functional properties

Cristian Torres-Leon et al.

JOURNAL OF FUNCTIONAL FOODS (2017)

Review Oncology

Cell cycle proteins as promising targets in cancer therapy

Tobias Otto et al.

NATURE REVIEWS CANCER (2017)

Review Pharmacology & Pharmacy

Targeting transcription factor STAT3 for cancer prevention and therapy

Edna Zhi Pei Chai et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Medicine, Research & Experimental

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

Jiandong Chen

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Article Chemistry, Multidisciplinary

Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid -Peptide Aggregation

Tahiri Sylla et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Integrative & Complementary Medicine

1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells

Shihab Deiab et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

Article Biochemical Research Methods

A validated liquid chromatography-tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Pimsumon Jiamboonsri et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2015)

Article Biochemistry & Molecular Biology

Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles

Pimsumon Jiamboonsri et al.

MOLECULES (2015)

Article Chemistry, Medicinal

Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora

Shu Zhu et al.

JOURNAL OF NATURAL MEDICINES (2015)

Article Biochemistry & Molecular Biology

In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity

Wenhua Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Agriculture, Multidisciplinary

Penta-O-galloyl-β-D-glucose Suppresses EGF-Induced elF3i Expression through Inhibition of the PI3K/AKT/mTOR Pathway in Prostate Cancer Cells

Victor Chia-Hsiang Lin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Article Pharmacology & Pharmacy

Penta-O-galloyl-β-D-glucose ameliorates inflammation by inhibiting MyD88/NF-κB and MyD88/MAPK signalling pathways

Se-Eun Jang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Chemistry, Medicinal

1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose Inhibits Angiogenesis via Inhibition of Capillary Morphogenesis Gene 2

Lorna M. Cryan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP+-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner

Hong Chen et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2012)

Article Chemistry, Applied

Low Molecular Weight Extractives from Green Husks of Juglans sigillata and Their Antioxidant Activities

Chuan-Ling Si et al.

JOURNAL OF BIOBASED MATERIALS AND BIOENERGY (2011)

Article Biochemistry & Molecular Biology

Vaccinia H1-related Phosphatase Is a Phosphatase of ErbB Receptors and Is Down-regulated in Non-small Cell Lung Cancer

Jiz-Yuh Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Oncology

Epidermal growth factor signalling and bone metastasis

X. Lu et al.

BRITISH JOURNAL OF CANCER (2010)

Article Pharmacology & Pharmacy

1,2,3,4,6-penta-O-galloyl-beta-D-glucose attenuates renal cell migration, hyaluronan expression, and crystal adhesion

Jae-Ho Lee et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Article Agriculture, Multidisciplinary

Penta-O-galloyl-β-D-glucose Suppresses Prostate Cancer Bone Metastasis by Transcriptionally Repressing EGF-Induced MMP-9 Expression

Po-Tsun Kuo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

Review Chemistry, Multidisciplinary

Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose

Jinhui Zhang et al.

PHARMACEUTICAL RESEARCH (2009)

Review Oncology

STATs in cancer inflammation and immunity: a leading role for STAT3

Hua Yu et al.

NATURE REVIEWS CANCER (2009)

Article Oncology

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation

Shao-Hua Chen et al.

CANCER BIOLOGY & THERAPY (2008)

Article Agriculture, Multidisciplinary

Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.)

Jacqueline C. Barreto et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Review Veterinary Sciences

Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease

Mauria A. O'Brien et al.

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE (2008)

Article Oncology

Clinical features of metastatic bone disease and risk of skeletal morbidity

Robert E. Coleman

CLINICAL CANCER RESEARCH (2006)

Review Peripheral Vascular Disease

Angiogenesis in cancer

Naoyo Nishida et al.

VASCULAR HEALTH AND RISK MANAGEMENT (2006)

Article Biochemistry & Molecular Biology

Enzymology of gallotannin and ellagitannin biosynthesis

R Niemetz et al.

PHYTOCHEMISTRY (2005)

Article Food Science & Technology

Effect of an extract from evening-primrose seeds on postprandial blood glucose level and its active components

M Aitani et al.

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI (2003)