Journal
MOLECULES
Volume 28, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules28062524
Keywords
onnamides; Theonella sp; marine sponges; histone modifications; cytotoxicity; marine natural products
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Two previously unreported onnamide analogs, 2Z- and 6Z-onnamides A (1 and 2), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. The structures of compounds 1 and 2 were determined by spectoral analysis. They exhibited structure-activity relationships in histone modifications and cytotoxicity against HeLa and P388 cells.
Two previously unreported onnamide analogs, 2Z- and 6Z-onnamides A (1 and 2), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by spectral analysis. Structure-activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity.
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