Journal
MOLECULES
Volume 28, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules28124687
Keywords
amphotericin B; nanoparticles; fungal infections; nanomedicine
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Amphotericin B-silver hybrid nanoparticles (AmB-Ag) are highly effective in combating fungi by disrupting the cell membrane.
Amphotericin B is a popular antifungal antibiotic, and despite decades of pharmacological application, the exact mode of its biological activity is still a matter of debate. Amphotericin B-silver hybrid nanoparticles (AmB-Ag) have been reported to be an extremely effective form of this antibiotic to combat fungi. Here, we analyze the interaction of AmB-Ag with C. albicans cells with the application of molecular spectroscopy and imaging techniques, including Raman scattering and Fluorescence Lifetime Imaging Microscopy. The results lead to the conclusion that among the main molecular mechanisms responsible for the antifungal activity of AmB is the disintegration of the cell membrane, which occurs on a timescale of minutes.
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