Journal
MOLECULES
Volume 28, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules28093809
Keywords
acetogenins; GBM; natural product; Annonaceae; mechanism of death; gliomas; matrix metalloproteinase; necroptosis; Annona coriacea
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This study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart. against GBM cell lines. The fractions showed selective cytotoxicity to GBM cells compared to TMZ, and also inhibited cell migration, MMP-2 activity, and induced necroptosis-like morphological changes. These findings suggest that the fractions of A. coriacea Mart. should be further studied for potential GBM treatment.
Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds. Accordingly, this study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart., enriched with acetogenins, against GBM cell lines. All four fractions were selectively cytotoxic to GBM cells when compared to TMZ. Moreover, A. coriacea fractions delayed cell migration; reduced cytoplasmic projections, the metalloproteinase 2 (MMP-2) activity; and induced morphological changes characteristic of necroptosis, possibly correlated with the increase in receptor-interacting protein kinase 1 and 3 (RIP-1 and RIP-3), apoptosis-inducing factor (AIF), and the non-activation of cleaved caspase 8. The present findings reinforce that fractions of A. coriacea Mart. should be considered for more studies focusing treatment of GBM.
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