Journal
MOLECULES
Volume 28, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules28041720
Keywords
ferulic acid; lipopolysaccharide; intestine permeability; intestinal barrier; ileal microbiota
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This study investigated the effects of ferulic acid (FA) on intestinal function and microflora in broilers challenged with lipopolysaccharide (LPS). The results showed that dietary FA supplementation improved intestinal function, preserved secretory immunoglobulin A (sIgA) levels, increased expression of tight junction proteins, and enhanced epithelial proliferation in LPS-challenged chickens. Additionally, FA supplementation rectified the disturbances in the ileal microflora caused by LPS. These findings highlight the potential of FA as a protective agent against LPS-induced intestinal damage and dysbiosis in broilers.
Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development and disrupted intestinal microbial composition and metabolism. Ferulic acid (FA) isolated from multiple plants exhibits multiple biological activities. This study investigated whether FA ameliorated intestinal function and microflora in LPS-challenged Tianfu broilers. The results showed that LPS challenge impaired intestinal function, as evidenced by decreased antioxidant functions (p < 0.05), disrupted morphological structure (p < 0.05), and increased intestinal permeability (p < 0.05); however, these adverse effects were improved by FA supplementation. Additionally, FA supplementation preserved sIgA levels (p < 0.05), increased mRNA expression levels of CLDN and ZO-1 (p < 0.05), and enhanced epithelial proliferation (p < 0.05) in the ileal mucosa in LPS-challenged chickens. Moreover, FA supplementation rectified the ileal microflora disturbances in the LPS-challenged broilers. The results demonstrate that dietary FA supplementation decreased LPS-induced intestinal damage by enhancing antioxidant capacity and maintaining intestinal integrity. Furthermore, FA supplementation protects intestinal tight junctions (TJs), elevates secretory immunoglobulin A (sIgA) levels, and modulates ileal microflora composition in LPS-challenged broilers.
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