4.6 Editorial Material

Cancer Prevention and Therapy by Targeting Oxidative Stress Pathways

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Short overview on the relevance of microRNA-reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment

Ozge Cemiloglu Ulker et al.

Summary: Modulation of oxidative stress-mediated signalling pathways as a novel anti-cancer treatment, particularly through the induction of lipid peroxidation, could be a significant approach in cancer therapy.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back

Jaime Gonzalez-Montero et al.

Summary: Cancer is a highly fatal disease with increasing prevalence. While the development of modern chemotherapy, radiotherapy, targeted therapies, and immunotherapy has brought new hope in the treatment of cancer, these therapies are also associated with frequent and sometimes severe adverse events. Ascorbate, a potent antioxidant, has been historically reported to have anti-tumor properties, but its deleterious effects due to interactions with iron have raised questions. Recent evidence suggests that high-dose ascorbate, particularly in cell systems with a high mitotic index, can positively modulate oxidative stress-induced cell death through ferroptosis. Ascorbate may also serve as an adjuvant in various cancer therapies by promoting tumor cell death through reactive oxygen species generation and ferroptosis. Re-examining ascorbate in cancer treatment could lead to the development of novel and safe strategies for its application in human medicine.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

The Identification of Prohibitin in the Rat Heart Mitochondria in Heart Failure

Yulia Baburina et al.

Summary: The study identified a decrease in the level of PHB in rat heart mitochondria with heart failure, and found that astaxanthin increased PHB content, suggesting a potential protective role. The interaction between PHB and other mitochondrial proteins in respiratory chain complexes was investigated under experimental conditions to understand this protective action.

BIOMEDICINES (2021)

Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

Review Biochemistry & Molecular Biology

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Sarmistha Saha et al.

MOLECULES (2020)

Article Multidisciplinary Sciences

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

Chenxia He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

Stephen Jun Fei Chong et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Biochemistry & Molecular Biology

Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

Kamelija Zarkovic et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Multidisciplinary Sciences

Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

Kiyotoshi Satoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell Biology

Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress

Jeremy Soon Kiat Chan et al.

CELL DEATH & DISEASE (2017)

Review Biochemistry & Molecular Biology

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

L. Milkovic et al.

FREE RADICAL RESEARCH (2015)

Review Cell Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

Kira M. Holmstroem et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Biochemistry & Molecular Biology

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Emilia Kansanen et al.

REDOX BIOLOGY (2013)