☆ 4.6 Article

In Vitro and In Silico Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from Graptophyllum pictum (Linn.) Griffith

MOLECULES (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Pterocarpus erinaceus Poir

Romeo Toko Feunaing et al.

Summary: Diabetes mellitus is a metabolic disorder that can cause various health complications, such as kidney failure, blindness, limb amputation, heart attack, and stroke. A study found that compounds extracted from the roots of Pterocarpus erinaceus have the potential to lower blood glucose levels by inhibiting certain enzymes related to carbohydrate digestion.

MOLECULES (2023)

Add to Collection

Article Chemistry, Applied

In vitro α-glucosidase inhibitory activity of isolated compounds and semisynthetic derivative from aerial parts of Erythrina senegalensis DC

Cyrille Tchuente Djoko et al.

NATURAL PRODUCT RESEARCH (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) PG Waterman

Hermia Nalova Ikome et al.

Summary: This research discovered compounds from the stem bark and fruit of Zanthoxylum gilletii, with compounds 3, 4, and 7 showing the strongest antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, these compounds were able to inhibit biofilm formation and violacein production, disrupting quorum sensing in pathogens.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2023)

Add to Collection

Article Chemistry, Applied

Cholinesterase, a-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of Rinorea oblongifolia CH Wright (Violaceae)

Aristide Mfifen Munvera et al.

Summary: New derivatives, 3-Nor-4 beta-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), were isolated and characterized from Rinorea oblongifolia fruits, along with other known compounds. The enzyme inhibitory activities of these compounds were evaluated, showing good activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-glucosidase, urease and tyrosinase. The results suggest that Rinorea oblongifolia and its constituents have potential therapeutic applications for enzymatic disorders.

NATURAL PRODUCT RESEARCH (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors

Po-Sen Tseng et al.

Summary: The conformation of substrate side chain affects reactivity in glycosylation and glycoside hydrolysis reactions and is restricted during catalysis by many enzymes. This study demonstrates that gluco and manno iminosugars can be restricted to specific conformations through strategic installation of a methyl group. Inhibition studies show that iminosugars with gauche,gauche conformation are 6-10 times more potent than those with gauche,trans conformation, and a manno-configured iminosugar with gauche,gauche conformation is 27 times better inhibitor than 1-deoxymannojirimycin. These results highlight the importance of side chain preorganization for improved inhibitor design in glycosidase inhibition.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Add to Collection

Article Pharmacology & Pharmacy

HPLC-DAD Phenolic Composition, Antioxidant, Anticholinesterase, Antidiabetic and Anti-quorum Sensing Properties of Bitter Kola (Garcinia kola) and Kolanut (Cola acuminata)

Sameh Boudiba et al.

Summary: Nigerian nuts, G. kola and C. acuminata, have high phenolic content and exhibit antioxidant, antidiabetic, and antimicrobial activities.

PHARMACOGNOSY RESEARCH (2023)

Add to Collection

Article Pharmacology & Pharmacy

Peptide conjugates of 18β-glycyrrhetinic acid as potent inhibitors of α-glucosidase and AGEs-induced oxidation

Sadiq Noor Khan et al.

Summary: The study evaluated the in vitro α-glucosidase inhibitory and antiglycation activities of 18β-GA-peptide conjugates 2-11, with conjugates 5 and 8 showing potent inhibition. Additionally, the peptide conjugates 2-11 also exhibited potential for inhibiting AGEs-induced NO· production.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Add to Collection

Article Plant Sciences

Histomorphometric study of ethanolic extract of Graptophyllum pictum (L.) Griff. leaves on croton oil-induced hemorrhoid mice: A Javanese traditional anti-hemorrhoid herb

Idha Kusumawati et al.

Summary: The study proved the effectiveness of Graptophyllum pictum in treating hemorrhoids, especially when used in combination with oral and topical administration.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Chemistry, Applied

A new abietane-type diterpenoid from roots of Burkea africana Hook (Fabaceae) with α-amylase inhibitory potential

Romeo Toko Feunaing et al.

Summary: A new abietane-type diterpenoid, rubesanolidic acid, and six known compounds were isolated from the roots of Burkea africana. The extract showed stronger alpha-amylase inhibition compared to the isolated compounds. The results suggest that B. africana could be a potential source of antidiabetic compounds.

NATURAL PRODUCT RESEARCH (2022)

Add to Collection

Article Chemistry, Applied

Chemical constituents from fruits of Cnestis ferruginea Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities

Therese Christelle Maleu et al.

Summary: A phytochemical investigation of Cnestis ferruginea fruits led to the discovery of a new quinic acid derivative, ferruginoic acid (1), which showed potential activity in managing Alzheimer's disease.

NATURAL PRODUCT RESEARCH (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth

Alfred Ngenge Tamfu et al.

Summary: Medicinal plants from Chad have rich phenolic composition and antioxidant activity, showing potential in managing oxidative stress-linked diseases.

ARABIAN JOURNAL OF CHEMISTRY (2022)

Add to Collection

Article Food Science & Technology

Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin

Koudoro Yaya Alain et al.

Summary: The study found that gum arabica extracted from acacia plants contains various beneficial components and has good antioxidant, antimicrobial, and enzyme-inhibiting activities. These results emphasize the importance of acacia in food applications.

LWT-FOOD SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Advances on Therapeutic Strategies for Alzheimer's Disease: From Medicinal Plant to Nanotechnology

Nasser A. Hassan et al.

Summary: Alzheimer's disease is a chronic dysfunction of neurons in the brain that leads to dementia. It is characterized by gradual mental decline, abnormal cognitive functioning, personality changes, diminished verbal fluency, and speech impairment. While there is no cure for AD, its progression can be delayed using FDA-approved drugs. An extensive literature survey and clinical trials have been conducted to explore various strategies for preventing the disease.

MOLECULES (2022)

Add to Collection

Article Chemistry, Analytical

In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents

Baraa M. I. S. Jadalla et al.

Summary: This study isolated several compounds with anti-diabetic activity from two species of Helichrysum plants and confirmed their anti-diabetic and antioxidant capacities through in vitro evaluation. These compounds have the potential to be candidate compounds for the development of anti-diabetic drugs.

SEPARATIONS (2022)

Add to Collection

Article Geriatrics & Gerontology

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019

Xue Li et al.

Summary: From 1990 to 2019, the burden of Alzheimer's disease increased significantly worldwide, with higher increases in high-SDI areas and among the elderly population in those areas. Incidence, prevalence, death, and DALYs rates were positively correlated with the sociodemographic index (SDI), with women having consistently higher rates than men. Risk factors such as smoking for men and obesity for women were identified.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Synthesis of benzoyl esters of β-amyrin and lupeol and evaluation of their antibiofilm and antidiabetic activities

Alfred Ngenge Tamfu et al.

Summary: Diabetes and enhanced microbial multidrug resistance due to biofilm formation are major global health problems. Triterpenoids and their derivatives have shown significant contributions in this field. A small library of benzoyl esters of lupeol and beta-amyrin was synthesized and evaluated for their inhibitory potential on pathogenic bacteria biofilms and on alpha-amylase and beta-glucosidase activities. The introduction of benzoyl ester groups at C-3 of lupeol and beta-amyrin substantially improved their antibiofilm and antidiabetic potentials.

RESULTS IN CHEMISTRY (2022)

Add to Collection

Review Neurosciences

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

Gabriella Marucci et al.

Summary: Alzheimer's disease is characterized by cognitive decline and behavioral manifestations, with the most common treatment being cholinesterase inhibitors. Despite their limited efficacy and gastrointestinal side effects, ChE-Is remain a pharmacotherapeutic resource for AD treatment. Investigating combinations with other drug classes may offer renewed interest in the use of ChE-Is for adult-onset dementia disorders.

NEUROPHARMACOLOGY (2021)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Recent Trends in Enzyme Inhibition and Activation in Drug Design

Athina Geronikaki

MOLECULES (2021)

Add to Collection

Article Chemistry, Physical

Molecular docking and simulation studies of a novel labdane type-diterpene from Moluccella aucheri Scheen (Syn. Otostegia aucheri) as human-AChE inhibitor

Mina Doorandishan et al.

Summary: Moluccella aucheri Scheen, native to Iran and Pakistan, contains five phytochemicals including a novel labdane typediterpene and four known compounds. Among them, compound 1 shows strong binding affinity towards human-AChE enzyme, suggesting its potential as a natural inhibitor of hAChE enzyme in vitro and in vivo tests.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Add to Collection

Review Cell Biology

Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease

Jesus Burillo et al.

Summary: This review examines the main molecular mechanisms that may be involved in the connection between type 2 diabetes and neurodegenerative diseases, with a focus on inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.

CELLS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Alfred Ngenge Tamfu et al.

Summary: Alzheimer's disease is a severe neurodegenerative disorder affecting more than 25 million people globally, with the main challenge being the development of new drugs for long-term treatment or prevention. Natural sources provide promising alternatives for this, with potential phytoconstituents showing low toxicity and high efficiency, serving as potential new therapeutic leads for Alzheimer's disease treatment.

MOLECULES (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews

Marta Perez-Gomez Moreta et al.

Summary: The study confirmed a low efficacy of AChEI in improving cognitive symptoms of patients with mild to moderate AD, especially in cognitive aspects. However, AChEI showed better effects in improving the global state, with donepezil being the most effective treatment. Nonetheless, there was no evidence of improvement in behavioral disturbances with the use of AChEI.

BIOMEDICINES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ent-Labdane and ent-kaurane diterpenoids from Chelonopsis odontochila with α-glucosidase inhibitory activity

Zhen-Tao Deng et al.

BIOORGANIC CHEMISTRY (2020)

Add to Collection

Article Biology

A new isoflavonol and other constituents from Cameroonian propolis and evaluation of their anti-inflammatory, antifungal and antioxidant potential

Alfred Ngenge Tamfu et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

Angelica Artasensi et al.

MOLECULES (2020)

Add to Collection

Review Neurosciences

Current Strategies and Novel Drug Approaches for Alzheimer Disease

Roma Ghai et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2020)

Add to Collection

Review Biology

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Ngan Tran et al.

BIOLOGY-BASEL (2020)

Add to Collection

Article Food Science & Technology

Antibiofilm and Enzyme Inhibitory Potentials of Two Annonaceous Food Spices, African Pepper (Xylopia aethiopica) and African Nutmeg (Monodora myristica)

Alfred Ngenge Tamfu et al.

FOODS (2020)

Add to Collection

Article Endocrinology & Metabolism

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Pouya Saeedi et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2019)

Add to Collection

Review Pharmacology & Pharmacy

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

Md Tanvir Kabir et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Add to Collection

Article Plant Sciences

Anti-inflammatory and α-Glucosidase Inhibitory Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes of Amomum villosum

Hong Yin et al.

JOURNAL OF NATURAL PRODUCTS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Organic and Mineral Composition of Seeds of Afrostyrax lepidophyllus Mildbr. and Evaluation of ROS Inhibition and Cytotoxicity of Isolated Compounds

Tamfu Alfred Ngenge et al.

CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase

Jirawat Riyaphan et al.

MOLECULES (2018)

Add to Collection

Article Chemistry, Applied

New mono-ether of glycerol and triterpenes with DPPH radical scavenging activity from Cameroonian propolis

Emmanuel Talla et al.

NATURAL PRODUCT RESEARCH (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives

Hatem A. Abuelizz et al.

MOLECULES (2017)

Add to Collection

Article Plant Sciences

In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca

Daniel M. Grochowski et al.

PHYTOCHEMISTRY LETTERS (2017)

Add to Collection

Review Endocrinology & Metabolism

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

Arun Chaudhury et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

Add to Collection

Review Chemistry, Medicinal

Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants

Waseem Hassan et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

Subbiah Pugazhenthi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Add to Collection

Article Integrative & Complementary Medicine

In vitro and in vivo α-amylase and α-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.)

Sundar Poovitha et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Add to Collection

Article

Oxytocic and anti-implantation activities of the leaf extracts of Graptophyllum pictum (Linn.) Griff. (Acanthaceae)

O Olagbende Dada Stella et al.

AFRICAN JOURNAL OF BIOTECHNOLOGY (2016)

Add to Collection

Review Pharmacology & Pharmacy

A review on Alzheimer's disease pathophysiology and its management: an update

Anil Kumar et al.

PHARMACOLOGICAL REPORTS (2015)

Add to Collection

Article Medicine, General & Internal

α-Glucosidase inhibitors and their use in clinical practice

Giuseppe Derosa et al.

ARCHIVES OF MEDICAL SCIENCE (2012)

Add to Collection

Article Chemistry, Medicinal

Phenolics from Bidens bipinnata and their amylase inhibitory properties

Xiao-Wei Yang et al.

FITOTERAPIA (2012)

Add to Collection

Article Chemistry, Medicinal

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

Jonah Cheung et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Add to Collection

Article Pharmacology & Pharmacy

Antidiabetic activity of aqueous bark extract of Cassia glauca in streptozotocin-induced diabetic rats

Md. Salahuddin et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2010)

Add to Collection

Review Chemistry, Medicinal

Natural Products as alpha-Amylase and alpha-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update

R. Tundis et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2010)

Add to Collection

Article Chemistry, Applied

Eremostachiin:: a new furanolabdane diterpene glycoside from Eremostachys glabra

A Delazar et al.

NATURAL PRODUCT RESEARCH (2006)

Add to Collection

Article Plant Sciences

Furanolabdane diterpenes from Hypoestes purpurea

CC Shen et al.

JOURNAL OF NATURAL PRODUCTS (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

Y Nicolet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.