Journal
MOLECULES
Volume 28, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules28041775
Keywords
N-O bond cleavage; oximes; hydroxylamines; N-hetercycles; transition-metal catalysis; radical reactions
Ask authors/readers for more resources
This article summarizes the importance of oximes and hydroxylamines as a class of skeletons, which not only widely exist in natural products and drug molecules, but also serve as synthons extensively used in industrial production. Due to the weak N-O sigma bonds of oximes and hydroxylamines, they can be easily transformed into other functional groups by N-O bond cleavage. Therefore, the synthesis of N-heterocycle using oximes and hydroxylamines as nitrogen sources has attracted wide attention.
Oximes and hydroxylamines are a very important class of skeletons that not only widely exist in natural products and drug molecules, but also a class of synthon, which have been widely used in industrial production. Due to weak N-O sigma bonds of oximes and hydroxylamines, they can be easily transformed into other functional groups by N-O bond cleavage. Therefore, the synthesis of N-heterocycle by using oximes and hydroxylamines as nitrogen sources has attracted wide attention. Recent advances for the synthesis of N-heterocycle through transition-metal-catalyzed and radical-mediated cyclization classified by the type of nitrogen sources and rings are summarized. In this paper, the recent advances in the N-O bond cleavage of oximes and hydroxylamines are reviewed. We hope that this review provides a new perspective on this field, and also provides a reference to develop environmentally friendly and sustainable methods.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available