Journal
CEREBELLUM
Volume 15, Issue 2, Pages 213-232Publisher
SPRINGER
DOI: 10.1007/s12311-015-0664-x
Keywords
Cerebellar ataxias; Anti-GAD antibodies; Hashimoto's encephalopathy; Primary autoimmune cerebellar ataxia; Gluten ataxia; Systemic lupus erythematosus; Miller Fisher syndrome; Paraneoplastic cerebellar degeneration
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Funding
- Japan Society for the Promotion of Science [24591358, 24790877]
- Singapore National Medical Research Council [IRG 10nov086, CSA/047/2012]
- Grants-in-Aid for Scientific Research [24790877, 24591358, 15K09440, 26860663] Funding Source: KAKEN
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In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.
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