Harnessing mitochondrial transplantation to sustain cardiac function: Another step forward

Article Engineering, Environmental

Transplantation of mitochondria encapsulated in hydrogel ameliorates myocardial ischemia-reperfusion injury

Ya Huang et al.

Summary: Mitochondria play a central role in myocardial ischemia-reperfusion (I/R) injury and mitochondrial transplantation (MTP) has therapeutic potential for treating I/R injury. In this study, Pluronic F127 (PF127) hydrogel was used to protect mitochondria during MTP, leading to improved cardiac function and reduced infarction size in mice after I/R injury. PF127 enhanced mitochondrial membrane potential and structural integrity, and improved the internalization of transplanted mitochondria into cardiomyocytes. Additionally, PF127-assisted MTP improved the mechanical and metabolic capacities of cardiomyocytes after hypoxia-reoxygenation injury.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Biotechnology & Applied Microbiology

Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance

Alian Zhang et al.

Summary: Mitochondrial dysfunction is a characteristic of heart failure, and mitochondrial transplantation has shown to restore heart function. This study demonstrates the efficacy of mitochondrial transplantation in two different heart failure models and reveals its protective effects on cardiac function and prevention of myocardial apoptosis. Furthermore, the study shows that the metabolic compatibility between transplanted mitochondria and treated cardiomyocytes is crucial for contraction improvement. Mitochondrial transplantation also preferentially boosts contraction in ventricular myocytes and enhances contractility in dystrophic cardiomyocytes without significant transcriptomic alterations.

MOLECULAR THERAPY (2023)

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Article Cardiac & Cardiovascular Systems