Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.

Automated summary

Behavioural supersensitivity may be caused by increased glutamate sensitivity and reduced dopamine sensitivity of D2-MSN. We propose that clozapine may address this issue by modulating glutamate activity, which may explain its unique effectiveness in treating treatment resistant schizophrenia.