4.7 Article

Comparative evaluation of PD-L1 expression in cytology imprints, circulating tumour cells and tumour tissue in non-small cell lung cancer patients

Related references

Note: Only part of the references are listed.
Article Pathology

Interobserver agreement of PD-L1 (SP263) assessment in advanced NSCLC on cytological smears and histological samples

Francesca Ambrosi et al.

Summary: This study evaluated the cyto-histological agreement and the PD-L1 interobserver agreement among three different pathologists on paired cytological smears and histological samples of advanced NSCLC. The results showed good agreement in CHA for some pathologists and moderate agreement in IrOA for smears. However, good agreement was observed for histological samples. Therefore, PD-L1 assessment on cytological smears should be improved and could be an alternative for patients without FFPE samples.

PATHOLOGY RESEARCH AND PRACTICE (2022)

Article Medical Laboratory Technology

Proficiency Testing to Assess Technical Performance for CTC-Processing and Detection Methods in CANCER-ID

Rui P. L. Neves et al.

Summary: This study aimed to evaluate the effectiveness of multiple technologies for detecting circulating tumor cells, establishing a multi-center evaluation platform. Results showed significant differences in the performance of different technologies in detecting cell lines, which will help in establishing standards for future clinical applications.

CLINICAL CHEMISTRY (2021)

Article Oncology

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50%

Martin Reck et al.

Summary: This study reports the first 5-year follow-up of a first-line immunotherapy trial for NSCLC, demonstrating that pembrolizumab provides a durable, clinically meaningful long-term overall survival benefit in first-line treatment of metastatic NSCLC with a PD-L1 tumor proportion score of at least 50%.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, General & Internal

Factors Influencing Concordance of PD-L1 Expression between Biopsies and Cytological Specimens in Non-Small Cell Lung Cancer

Mohammed S. I. Mansour et al.

Summary: The study found a good correlation between PD-L1 expression in cytology specimens and histological specimens, with different types of biopsies not significantly impacting the concordance. A high amount of tumor cells in biopsies may enhance the cyto-histological PD-L1 concordance.

DIAGNOSTICS (2021)

Review Oncology

Circulating Biomarkers of Response and Toxicity of Immunotherapy in Advanced Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review

Alice Indini et al.

Summary: Although immunotherapy has transformed the treatment of non-small cell lung cancer, not all patients benefit from it. Liquid biopsy, as a non-invasive diagnostic tool, can help in selecting potential responders to immunotherapy and identifying those at higher risk for immune-related adverse events.

CANCERS (2021)

Review Pathology

PD-L1 Testing in Cytological Non-Small Cell Lung Cancer Specimens: A Comparison with Biopsies and Review of the Literature

Mohammed S. I. Mansour et al.

Summary: The overall concordance of PD-L1 between cytology and biopsies is quite good, but there is significant variation between laboratories, highlighting the importance of local quality assurance. The study found that samples from different sites had lower concordance, underscoring the need for further research and quality assurance measures in these cases.

ACTA CYTOLOGICA (2021)

Article Medical Laboratory Technology

Programmed Cell Death Ligand 1-Expressing Circulating Tumor Cells: A New Prognostic Biomarker in Non-Small Cell Lung Cancer

Lea Sinoquet et al.

Summary: The presence of PD-L1(+) CTCs is associated with poor prognosis in patients with advanced NSCLC, showing low concordance with PD-L1 expression in tumor tissue, and further studies with larger samples are needed for confirmation.

CLINICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis

Desiree Loreth et al.

Summary: CTCs can serve as a disease surrogate for brain metastases in lung, melanoma, and breast cancer patients, with CD44 and CD74 expression as prognostic markers. Detection of CTCs using a size-based microfluidic approach and a semi-automated cell recognition system allows further characterization of tumor cells possibly derived from brain metastases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Medicine, Research & Experimental

Emerging role of circulating tumor cells in immunotherapy

Alexey Rzhevskiy et al.

Summary: Immunotherapy, particularly immune checkpoint inhibitor therapy, has revolutionized cancer treatment in recent years. However, slow uptake in clinical oncology is attributed to high treatment costs, associated toxicities, and variability in patient response. Personalized approaches based on predictive biomarkers have emerged as new tools to enhance the effectiveness of immunotherapy.

THERANOSTICS (2021)

Article Oncology

Formalin fixation for optimal concordance of programmed death-ligand 1 immunostaining between cytologic and histologic specimens from patients with non-small cell lung cancer

Bregje M. Koomen et al.

Summary: This study found that the concordance of PD-L1 immunostaining between cytologic and histologic samples is influenced by fixatives and fixation times. Fixation in alcohol-based fixatives may lead to false-negative results, while fixation in formalin can result in higher and more histology-concordant PD-L1 immunostaining.

CANCER CYTOPATHOLOGY (2021)

Article Medical Laboratory Technology

Utility of PD-L1 immunocytochemistry using body-fluid cell blocks patients with non-small-cell lung cancer

Seung GeunDoo Song et al.

DIAGNOSTIC CYTOPATHOLOGY (2020)

Review Biochemistry & Molecular Biology

Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy

Xiaoming Zhong et al.

MOLECULAR CANCER (2020)

Review Medicine, General & Internal

Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

Narjust Duma et al.

MAYO CLINIC PROCEEDINGS (2019)

Review Biochemistry & Molecular Biology

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

Ming Yi et al.

MOLECULAR CANCER (2018)

Article Anatomy & Morphology

Small Biopsies Misclassify up to 35% of PD-L1 Assessments in Advanced Lung Non-Small Cell Lung Carcinomas

Gilbert Bigras et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2018)

Article Medical Laboratory Technology

Accession of Tumor Heterogeneity by Multiplex Transcriptome Profiling of Single Circulating Tumor Cells

Tobias M. Gorges et al.

CLINICAL CHEMISTRY (2016)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

Julie Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

H. Borghaei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Anatomy & Morphology

Development of an Automated PD-L1 Immunohistochemistry (IHC) Assay for Non-Small Cell Lung Cancer

Therese Phillips et al.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2015)