Targeting protein folding in N-Myc-driven medulloblastoma

Article Biochemical Research Methods

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma

Cheng Cheng et al.

Summary: This study aimed to explore novel ways to indirectly target N-Myc by regulating its post-translational modifications (PTMs) and therefore protein stability. The researchers discovered that p300 can modulate the protein stability of N-Myc and is correlated with poor prognosis in NB patients.

MOLECULAR & CELLULAR PROTEOMICS (2023)

Add to Collection

Article Oncology

N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma

Duygu Kuzuoglu-Ozturk et al.

Summary: Deregulation of N-myc is a major cause of malignant brain tumors in children. This study characterizes the translatome of medulloblastoma and reveals that N-myc drives selective translation of transcripts promoting protein homeostasis. These findings identify a hidden molecular program promoting medulloblastoma formation and suggest potential new therapies for clinical use.

CANCER RESEARCH (2023)

Add to Collection

Article Oncology

Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo

Barbara Jonchere et al.

Summary: Despite improvement in medulloblastoma treatment, many patients with MYC and MYCN-driven tumors still do not benefit. High-throughput drug combination screens revealed that the combination of CDK4/6 inhibitors with BET or PI3K/mTOR inhibitors enhanced the inhibition of cell proliferation. However, this combination did not significantly improve the survival of G3 and SHH medulloblastoma-bearing mice in vivo.

MOLECULAR CANCER THERAPEUTICS (2023)

Add to Collection

Review Oncology