4.7 Article

PPM1D activity promotes the replication stress caused by cyclin E1 overexpression

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

Jingkun Zeng et al.

Summary: Whole-genome duplication (WGD) is a frequent event in cancer evolution, and the p53 tumor suppressor plays a dual role in this process. It can act as a barrier to WGD by blocking the proliferation of tetraploid cells, but it can also promote mitotic bypass, a key step in WGD. In wild-type p53 tumors, WGD is often associated with activation of the E2F pathway, particularly the amplification of CCNE1. High expression of cyclin E1 causes replicative stress, leading to G2 phase arrest. p53, along with its downstream target p21 and Wee1, inhibits mitotic cyclin-dependent kinase activity, activating APC/CCdh1 and promoting mitotic bypass.
Article Biochemistry & Molecular Biology

The consequences of differential origin licensing dynamics in distinct chromatin environments

Liu Mei et al.

Summary: In this study, the authors quantified the dynamics and distribution of DNA replication origin licensing for the first time. They found that the loading rate of MCM complexes is different between euchromatin and heterochromatin. The study also revealed the consequences of heterochromatin licensing dynamics, leading to DNA damage accumulation in subsequent phases. Therefore, the length of G1 phase is critical for sufficient MCM loading, genome duplication, and genome stability.

NUCLEIC ACIDS RESEARCH (2022)

Article Biology

Quantitative profiling of adaptation to cyclin E overproduction

Juanita C Limas et al.

Life Science Alliance (2022)

Article Cell Biology

MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

Celeste Giansanti et al.

Summary: The MDM2 oncoprotein antagonizes p53 and sustains DNA replication fork progression, even in the absence of functional p53. This study demonstrates that MDM2 binds, inhibits, ubiquitinates, and destabilizes PARP1, resulting in accelerated fork progression. MDM2 also reduces fork reversal frequency, increases micronuclei occurrence, and exacerbates cell death, resembling the effects of PARP inhibition. These findings suggest that high MDM2 levels may represent a vulnerability of cancer cells.

CELL REPORTS (2022)

Review Oncology

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?

Linda Zhang et al.

Summary: PPM1D, a central negative regulator of DNA damage response, is mutated or amplified in many solid cancers and associated with increased proliferative and metastatic behavior. Recent findings have sparked interest in PPM1D's role in hematologic malignancies, with its mutations being commonly found in clonal hematopoiesis. Further research is needed to understand the divergent roles of PPM1D in solid vs hematologic cancers and its potential implications for new therapeutic avenues.

MOLECULAR CANCER RESEARCH (2022)

Review Cell Biology

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

Rafaela Fagundes et al.

Summary: DNA replication must be precisely controlled, and cell cycle transitions are regulated by the Cyclin-Dependent Kinases (CDKs) family. The Cyclin E/CDK2 complex controls cell cycle progression and DNA replication through phosphorylation of specific substrates in normal cycles, while its oncogenic activation causes replication stress and genomic instability.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence

Jacob Peter Matson et al.

JOURNAL OF CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

Morgane Macheret et al.

NATURE (2018)

Article Cell & Tissue Engineering

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Joanne Hsu et al.

CELL STEM CELL (2018)

Article Multidisciplinary Sciences

Chromatin modifiers Mdm2 and RNF2 prevent RNA: DNA hybrids that impair DNA replication

Ina Klusmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration

Himjyot Jaiswal et al.

EMBO JOURNAL (2017)

Article Multidisciplinary Sciences

DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression

Stephanie Hamppa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cell Biology

p53 Activity Results in DNA Replication Fork Processivity

Ina Klusmann et al.

CELL REPORTS (2016)

Article Biotechnology & Applied Microbiology

Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons

Hilda van den Bos et al.

GENOME BIOLOGY (2016)

Article Multidisciplinary Sciences

Chromothripsis from DNA damage in micronuclei

Cheng-Zhong Zhang et al.

NATURE (2015)

Review Oncology

Replication stress and cancer

Helene Gaillard et al.

NATURE REVIEWS CANCER (2015)

Review Cell Biology

Causes and consequences of replication stress

Michelle K. Zeman et al.

NATURE CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

Aidan G. Gilmartin et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Multidisciplinary Sciences

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

Indra A. Shaltiel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Luis Ignacio Toledo et al.

Article Cell Biology

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

Petra Kleiblova et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Multidisciplinary Sciences

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

Assaf C. Bester et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

Article Cell Biology

Origin licensing and p53 status regulate Cdk2 activity during G1

Kathleen R. Nevis et al.

CELL CYCLE (2009)

Article Biochemistry & Molecular Biology

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

Arne Lindqvist et al.

EMBO JOURNAL (2009)

Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

Review Multidisciplinary Sciences

An oncogene-induced DNA damage model for cancer development

Thanos D. Halazonetis et al.

SCIENCE (2008)

Article Multidisciplinary Sciences

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

T Fujiwara et al.

NATURE (2005)

Article Cell Biology

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

XB Lu et al.

GENES & DEVELOPMENT (2005)

Article Multidisciplinary Sciences

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

J Bartkova et al.

NATURE (2005)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation

AC Minella et al.

CURRENT BIOLOGY (2002)

Article Genetics & Heredity

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

DV Bulavin et al.

NATURE GENETICS (2002)