4.6 Review

Therapeutic Landscape of AXL Receptor Kinase in Triple-Negative Breast Cancer

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Identification of an AXL kinase inhibitor in triple-negative breast cancer by structure-based virtual screening and bioactivity test

Pei Li et al.

Summary: The compound Y041-5921 has been identified as a potential targeted therapeutic drug for triple-negative breast cancer (TNBC) by inhibiting the proliferation and invasion of TNBC cells. It also shows lower toxicity to normal breast epithelial cells compared to conventional chemotherapy drugs, and exhibits inhibitory effects on the proliferation of various other malignant tumor cell lines. The interaction mechanism between Y041-5921 and AXL has been studied through molecular dynamics simulations, providing a foundation for the development of TNBC treatment.

CHEMICAL BIOLOGY & DRUG DESIGN (2022)

Review Oncology

AXL Receptor Tyrosine Kinase as a Promising Therapeutic Target Directing Multiple Aspects of Cancer Progression and Metastasis

Marie-Anne Goyette et al.

Summary: Metastasis is a complex process involving the acquisition of specific traits by cancer cells and the cooperation of non-neoplastic cells in the stroma. AXL receptor tyrosine kinase plays a crucial role in multiple steps of the metastatic cascade and contributes to deregulation of the tumor microenvironment. Inhibition of AXL has been shown to be beneficial for the treatment of metastatic cancers, but other roles of AXL in cancer progression are still being explored.

CANCERS (2022)

Article Cell Biology

A phase 1-2 trial of sitravatinib and nivolumab in clear cell renal cell carcinoma following progression on antiangiogenic therapy

Pavlos Msaouel et al.

Summary: The accumulation of immune-suppressive myeloid cells is a critical factor in resistance to anti-PD-1 therapy in advanced ccRCC. A phase 1-2 trial found that combining sitravatinib with nivolumab improved treatment outcomes and reduced immune-suppressive myeloid cells. Baseline peripheral blood neutrophil-to-lymphocyte ratio and liver metastases were found to be correlated with treatment response, with patients showing durable responses.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Multidisciplinary Sciences

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer

Anna Adam-Artigues et al.

Summary: AXL overexpression is identified as an essential mechanism of trastuzumab resistance in HER2-positive breast cancer, and targeting AXL can restore trastuzumab response. AXL may serve as a predictive biomarker for prognosis in HER2-positive breast cancer patients. The study emphasizes the importance of targeting AXL in combination with anti-HER2 drugs to overcome resistance.

SCIENCE ADVANCES (2022)

Article Cell Biology

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop

Yingying Shen et al.

Summary: This study found that the small-molecule tyrosine kinase inhibitor DCC-2036 can suppress breast cancer stem cells by inhibiting the AXL and KLF5 proteins. Additionally, DCC-2036 has the potential to increase the effectiveness of chemotherapy for TNBC.

CELL DEATH & DISEASE (2022)

Article Oncology

MicroRNA-432 Acts as a Prognostic Biomarker and an Inhibitor of Cell Proliferation, Migration, and Invasion in Breast Cancer

Jianhua Wu et al.

Summary: This study investigated the potential role of miR-432 in breast cancer and found that it may act as a tumor suppressor by inhibiting cell proliferation, migration, and invasion. MiR-432 could be a prognostic biomarker and therapeutic target for breast cancer treatment, providing a novel insight into breast cancer prognosis and treatment.

CLINICAL BREAST CANCER (2021)

Article Genetics & Heredity

MicroRNA 34a-AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells

Dansaem Lim et al.

Summary: Targeting tumor vasculature is an appealing strategy for cancer treatment, but the heterogeneous nature and complex mechanisms of tumor neovascularization present challenges. AXL receptor tyrosine kinase (AXL) has been identified as a key regulator of vasculogenic mimicry (VM) formation in breast cancer cells, with the miR-34a-AXL axis being critical for the regulation of VM formation and a potential therapeutic target for inhibiting tumor neovascularization.

GENES (2021)

Article Oncology

Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling

Mai Tanaka et al.

Summary: The study found that inhibiting Axl in prostate and breast cancer cells can significantly reduce metastatic potential, and inhibiting Axl signaling in osteoclast precursor cells can also reduce the formation of mature osteoclasts. In vivo, Axl knockdown in prostate and breast cancer cells significantly suppressed the formation and progression of bone metastases. Therefore, therapeutic targeting of Axl may impair tumor metastasis to the bones through neoplastic and host cell signaling axes.

CLINICAL & EXPERIMENTAL METASTASIS (2021)

Review Oncology

Immune Evasion Mechanism and AXL

Hye-Youn Son et al.

Summary: The focus on cancer immunotherapy has led to increased interest in targeting AXL, a receptor tyrosine kinase that plays a role in cancer progression and immune evasion. The GAS6/AXL pathway is implicated in promoting cancer cell proliferation, survival, and immune escape, making it a potential therapeutic target with implications for immune responses.

FRONTIERS IN ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

lncRNA GSEC Promotes the Progression of Triple Negative Breast Cancer (TNBC) by Targeting the miR-202-5p/AXL Axis

Jianhua Zhang et al.

Summary: GSEC was significantly upregulated in TNBC tissues and cancer cell lines, and high level of GSEC was associated with advanced tumor stage, positive lymph-node metastasis and poor prognosis of TNBC patients. Knockdown of GSEC effectively inhibited TNBC cell proliferation, invasion and migration in vitro. GSEC regulated the expression of AXL by directly sponging miR-202-5p.

ONCOTARGETS AND THERAPY (2021)

Review Oncology

The Role of the Receptor Tyrosine Kinase Axl in Carcinogenesis and Development of Therapeutic Resistance: An Overview of Molecular Mechanisms and Future Applications

Martha Wium et al.

Summary: Axl is an oncogene that promotes cancer development and resistance to therapy, with inhibitors currently in clinical trials. Understanding the role of Axl in drug resistance can lead to improved cancer therapeutic strategies.

CANCERS (2021)

Article Biology

The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

Lohit Khera et al.

Summary: The AXL-PYK2-PKCα signaling network plays a crucial role in regulating stemness in triple-negative breast cancer, involving multiple pathways and suggesting a potential therapeutic strategy for targeting cancer stem cells.

LIFE SCIENCE ALLIANCE (2021)

Article Oncology

Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells

Hong Chang et al.

Summary: Axl receptor tyrosine kinase is a promising target for cancer therapy due to its involvement in tumor cell growth and migration. Monoclonal antibodies targeting the functional domain of Axl have shown inhibitory effects on Axl-Gas6 binding, indicating their potential in cancer treatment.

ONCOLOGY LETTERS (2021)

Article Oncology

AXL Overexpression in Tumor-Derived Endothelial Cells Promotes Vessel Metastasis in Patients With Hepatocellular Carcinoma

Zong-Tao Chai et al.

Summary: The study found that high AXL expression in TECs is associated with poor prognosis in HCC patients and promotes cell migration and tube formation through activation of the PI3K/AKT/SOX2/DKK-1 axis.

FRONTIERS IN ONCOLOGY (2021)

Article Cell & Tissue Engineering

Cancer stem cell-targeted therapeutic approaches for overcoming trastuzumabresistance in HER2-positive breast cancer

Yan Qiu et al.

Summary: The use of the anti-HER2 drug trastuzumab has significantly improved the prognosis of HER2-positive breast cancer patients, but 50% of patients relapse due to trastuzumab resistance, which is closely related to the presence of breast cancer stem cells (BCSCs). BCSCs are resistant to conventional therapy and may drive distant metastasis and cancer relapse.

STEM CELLS (2021)

Article Multidisciplinary Sciences

Soluble AXL as a marker of disease progression and survival in melanoma

Karine Flem-Karlsen et al.

PLOS ONE (2020)

Review Oncology

AXL as a Target in Breast Cancer Therapy

Sierra A. Colavito

JOURNAL OF ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells

Yeon-Sang Ryu et al.

BIOMOLECULES & THERAPEUTICS (2020)

Article Oncology

Gas6 expression is reduced in advanced breast cancers

Ayman M. Ibrahim et al.

NPJ PRECISION ONCOLOGY (2020)

Article Multidisciplinary Sciences

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

Afnan Abu-Thuraia et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review

Simona Ruxandra Volovat et al.

FRONTIERS IN ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations

Italia Falcone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression

Lorena Quirico et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Pharmacology & Pharmacy

Cabozantinib-related cardiotoxicity: a prospective analysis in a real-world cohort of metastatic renal cell carcinoma patients

Roberto Iacovelli et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Article Endocrinology & Metabolism

Management of Medullary Thyroid Cancer

David Viola et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2019)

Article Critical Care Medicine

Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis

Milena S. Espindola et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Correction Biochemistry & Molecular Biology

Comprehensive Characterization of Cancer Driver Genes and Mutations (vol 173, 371.e1, 2018)

Matthew H. Bailey et al.

Review Biochemistry & Molecular Biology

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

Abdullah Hoter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer

Shadan Hajalirezay Yazdi et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2018)

Article Oncology

Expression of Axl and its prognostic significance in human breast cancer

Gaoyuan Jin et al.

ONCOLOGY LETTERS (2017)

Article Multidisciplinary Sciences

Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

Stanley G. Kimani et al.

SCIENTIFIC REPORTS (2017)

Review Oncology

Giving AXL the axe: targeting AXL in human malignancy

Carl M. Gay et al.

BRITISH JOURNAL OF CANCER (2017)

Article Biochemistry & Molecular Biology

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Chun-Yu Cho et al.

Article Oncology

Impact of Expression of Vimentin and Axl in Breast Cancer

Kimihiro Tanaka et al.

CLINICAL BREAST CANCER (2016)

Article Oncology

Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy

Maurizio Scaltriti et al.

CLINICAL CANCER RESEARCH (2016)

Article Multidisciplinary Sciences

Reprogramming the immunological microenvironment through radiation and targeting Axl

Todd A. Aguilera et al.

NATURE COMMUNICATIONS (2016)

Article Cell Biology

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Francesca Zanconato et al.

NATURE CELL BIOLOGY (2015)

Article Oncology

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Catherine Wilson et al.

CANCER RESEARCH (2014)

Review Oncology

The receptor tyrosine kinase Axl in cancer: Biological functions and therapeutic implications

Juliano D. Paccez et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Medicine, Research & Experimental

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

Manikandan Subramanian et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Pathology

Axl receptor tyrosine kinase expression in breast cancer

Timothy M. D'Alfonso et al.

JOURNAL OF CLINICAL PATHOLOGY (2014)

Article Multidisciplinary Sciences

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Magdalena Paolino et al.

NATURE (2014)

Review Oncology

AXL kinase as a novel target for cancer therapy

Xiaoliang Wu et al.

ONCOTARGET (2014)

Review Oncology

Axl as a mediator of cellular growth and survival

Haley Axelrod et al.

ONCOTARGET (2014)

Article Immunology

Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development

Il-Kyoo Park et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays

T. S. Gujral et al.

ONCOGENE (2013)

Review Biochemistry & Molecular Biology

Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands

Thomas Schmidt et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemical Research Methods

Systematic Identification of the HSP90 Candidate Regulated Proteome

Zhixiang Wu et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Article Biotechnology & Applied Microbiology

Targeting Axl With an High-affinity Inhibitory Aptamer

Laura Cerchia et al.

MOLECULAR THERAPY (2012)

Article Multidisciplinary Sciences

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt et al.

NATURE (2012)

Article Multidisciplinary Sciences

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis et al.

NATURE (2012)

Article Medicine, Research & Experimental

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biochemistry & Molecular Biology

Control of mammary tumor differentiation by SKI-606 (bosutinib)

L. Hebbard et al.

ONCOGENE (2011)

Article Biochemistry & Molecular Biology

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

G. Mudduluru et al.

ONCOGENE (2011)

Article Multidisciplinary Sciences

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

Christine Gjerdrum et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

Victoria Sanz-Moreno et al.

Article Immunology

Twist mediates suppression of inflammation by type IIFNs and Axl

M. Nusrat Sharif et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Review Biochemistry & Molecular Biology

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

Sassan Hafizi et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2006)

Article Biochemistry & Molecular Biology

Effects of Gash and hydrogen peroxide in Axl ubiquitination and downregulation

P Valverde

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Hematology

Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses

WR Gould et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

Article Biochemistry & Molecular Biology

Gas6 anti-apoptotic signaling requires NF-κB activation

F Demarchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)