4.7 Article

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification

Carla Montironi et al.

Summary: This study characterizes the immunogenomic contexture of hepatocellular carcinoma (HCC) and defines inflamed and non-inflamed tumors. Two distinct patterns of CTNNB1 are associated with differential immune evasion and may help predict immune response in HCC.
Review Oncology

Immunotherapies for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally. Traditional treatments involve specific drugs, but the emergence of immune checkpoint inhibitors has revolutionized the management of HCC.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Review Oncology

Biological roles of RNA m5C modification and its implications in Cancer immunotherapy

Hang Song et al.

Summary: Epigenetics, including DNA and RNA modifications, has been a hot topic in the field of life sciences in the post-genome era. In recent years, a wide range of RNA modifications, including m(5)C modification, have been discovered. m(5)C modification is a reversible epigenetic modification that affects the fate of RNA molecules and plays important roles in various biological processes, such as RNA stability control, protein synthesis, and transcriptional regulation. Accumulative evidence also suggests a potential role of RNA m(5)C in tumorigenesis and cancer immunotherapy.

BIOMARKER RESEARCH (2022)

Review Biochemistry & Molecular Biology

The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

Paz Nombela et al.

Summary: RNA modifications play a critical role in gene expression regulation, influencing biological processes and disease development, particularly in cancer.

MOLECULAR CANCER (2021)

Article Biochemistry & Molecular Biology

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6

Tommaso Selmi et al.

Summary: The study identifies NSUN6 as a methyltransferase targeting mRNA, primarily in 3'UTRs, involved in translation termination fidelity as part of a quality control mechanism.

NUCLEIC ACIDS RESEARCH (2021)

Review Biochemistry & Molecular Biology

RNA 5-methylcytosine modification and its emerging role as an epitranscriptomic mark

Yaqi Gao et al.

Summary: 5-methylcytosine (m(5)C) is a common and conserved modification in various RNAs, playing critical roles in RNA processing and being associated with pathological processes such as neurological disorders and cancers.

RNA BIOLOGY (2021)

Article Oncology

Writers, readers and erasers of RNA modifications in cancer

Rosaura Esteve-Puig et al.

CANCER LETTERS (2020)

Article Biochemistry & Molecular Biology

CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators

Liang Fang et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Review Oncology

Role of RNA modifications in cancer

Isaia Barbieri et al.

NATURE REVIEWS CANCER (2020)

Article Multidisciplinary Sciences

Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

Vahid Khoddami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Genome-wide identification of mRNA 5-methylcytosine in mammals

Tao Huang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

Lindsey Van Haute et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Post-transcriptional regulation by cytosine-5 methylation of RNA

Raquel Garcia-Vilchez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2019)

Review Genetics & Heredity

Clinical epigenetics: seizing opportunities for translation

Maria Berdasco et al.

NATURE REVIEWS GENETICS (2019)

Review Biochemistry & Molecular Biology

Bromodomain inhibitors and cancer therapy: From structures to applications

Montserrat Perez-Salvia et al.

EPIGENETICS (2017)

Article Gastroenterology & Hepatology

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

Daniela Sia et al.

GASTROENTEROLOGY (2017)

Review Chemistry, Multidisciplinary

Protein Domain Mimics as Modulators of Protein-Protein Interactions

Nicholas Sawyer et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

A Landscape of Pharmacogenomic Interactions in Cancer

Francesco Iorio et al.

Article Biochemistry & Molecular Biology

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

Saumya Jain et al.

Article Multidisciplinary Sciences

Stem cell function and stress response are controlled by protein synthesis

Sandra Blanco et al.

NATURE (2016)

Article Cell Biology

Epigenetic Determinants of Cancer

Stephen B. Baylin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Article Gastroenterology & Hepatology

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

Augusto Villanueva et al.

HEPATOLOGY (2015)

Article Biochemistry & Molecular Biology

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Alfredo Castello et al.

Article Biochemistry & Molecular Biology

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

Francesca Tuorto et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Jeffrey E. Squires et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E. Delmore et al.

Article Biochemical Research Methods

SAINT: probabilistic scoring of affinity purification-mass spectrometry data

Hyungwon Choi et al.

NATURE METHODS (2011)

Article Multidisciplinary Sciences

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Focal gains of VEGFA and molecular classification of hepatocellular carcinoma

Derek Y. Chiang et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control

Perconti Giovanni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Biochemistry & Molecular Biology

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors

Michaela Frye et al.

CURRENT BIOLOGY (2006)