☆ 4.7 Review

New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

MOLECULAR CANCER (2023)

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Article Oncology

Pediatric medulloblastoma express immune checkpoint B7-H3

S. Li et al.

Summary: This study examined the expression of immune checkpoint B7-H3 in pediatric MB. The results showed that B7-H3 was highly expressed in the majority of cases and that high expression of B7-H3 was associated with reduced infiltration of gamma delta T cells and CD3+ T cells.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Article Cell Biology

LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma

Huan Li et al.

Summary: This study investigates the regulatory mechanism of LINC01123 in head and neck squamous-cell carcinoma (HNSCC) and its correlation with immunity. The findings demonstrate that LINC01123 competitively binds to miR-214-3p and upregulates B7-H3, leading to the inhibition of CD8(+)T-cell activation and the promotion of HNSCC progression.

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B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Taito Miyamoto et al.

Summary: This study explored the immunosuppressive effect of B7-H3 in high-grade serous ovarian cancer (HGSOC) and found that it contributes to immune suppression and tumor progression through the CCL2-CCR2-M2 macrophage axis. These findings provide new insights into the immunologic tumor microenvironment and could aid the development of new therapeutic approaches.

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Article Oncology

Co-deficiency of B7-H3 and B7-H4 identifies high CD8+T cell infiltration and better prognosis in pancreatic cancer

Shuping Si et al.

Summary: This study found that B7-H3 and B7-H4 were highly expressed in pancreatic adenocarcinoma (PAAD) and were associated with tumor differentiation and prognosis. Co-deficiency of B7-H3 and B7-H4 indicated a better prognosis and immune-hot tumors with high CD8+ T cell infiltration.

BMC CANCER (2022)

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Clinical significance and correlation of PD-L1, B7-H3, B7-H4, and TILs in pancreatic cancer

Jiayue Yang et al.

Summary: We systematically analyzed the expression patterns of B7 molecules and proposed a novel subtyping strategy in PaCa. Patients with both high PD-L1 and B7-H4 expression exhibited the immuno-cold phenotype, which may be not suitable for immunotherapy.

BMC CANCER (2022)

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3-and B7H4-dependent anti-tumor immunity in colorectal cancer

Kenneth Peuker et al.

Summary: Bacterial sensing by intestinal tumor cells contributes to tumor growth through the calcineurin-NFAT axis, while its inhibition can activate CD8(+) T cell responses and inhibit colorectal cancer growth. This pathway also controls the expression of B7H3 and B7H4 by tumor cells, which inhibits CD8(+) T cell-dependent anti-tumor immunity.

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The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Elodie Picarda et al.

Summary: The immune checkpoint B7-H3 has been studied in the tumor microenvironment and immunotherapy, but its potential role in metabolism remains largely unknown. This study reveals that B7-H3 is highly expressed in adipose tissue, particularly in adipocyte progenitor cells, and it regulates the glycolytic and mitochondrial activity of these cells. Loss of B7-H3 leads to impaired oxidative metabolism and increased lipid accumulation in derived adipocytes. Knockout of B7-H3 in mice results in spontaneous obesity, metabolic dysfunction, and adipose tissue inflammation.

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Clinical Significance of the Expression of Co-Stimulatory Molecule B7-H3 in Papillary Thyroid Carcinoma

Bohui Zhao et al.

Summary: This study provides a comprehensive analysis of the expression profile of B7-H3 in papillary thyroid carcinoma (PTC). The findings suggest that B7-H3 can serve as an independent biomarker for predicting lymph node metastasis and disease recurrence in PTC patients, making it a potential target for improving therapeutic strategies and immunotherapy.

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DNA Methylation and mRNA Expression of B7-H3 Gene in Ankylosing Spondylitis: A Case-Control Study

Yuting Chen et al.

Summary: This study explored the association between the B7-H3 gene and AS in an eastern Chinese Han population. The researchers found that hypomethylation of the B7-H3 gene promoter was observed in AS patients, and B7-H3 gene expression was significantly enhanced in AS patients. These findings suggest that epigenetic modifications of B7-H3 are associated with susceptibility to AS.

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Genome-scale CRISPR-Cas9 screen reveals novel regulators of B7-H3 in tumor cells

Shasha Zhao et al.

Summary: This study identified the crucial role of transcription factor SP20H in regulating B7-H3 expression and tumor progression, suggesting its potential as a target for improving anti-B7-H3 therapy.

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Summary: This article discusses the demand and opportunities brought about by the rapid adoption of immune checkpoint blockade therapy. It presents new biomarker candidates and investigates their biological mechanisms and how they fit into the existing landscape of ICB biomarkers. Additionally, the article discusses the challenges of using biomarker-derived models to facilitate the development of new immunotherapies.

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B7-H3 is spliced by SRSF3 in colorectal cancer

Chunxia Zhang et al.

Summary: The study identified SRSF3 as a splicing factor involved in the regulation of B7-H3 expression, impacting the prognosis of CRC patients. High expression of SRSF3 and B7-H3 correlates with poor patient outcomes, suggesting SRSF3 as a potential target for regulating B7-H3 expression and CRC therapy.

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B7-H3 augments the pro-angiogenic function of tumor-associated macrophages and acts as a novel adjuvant target for triple-negative breast cancer therapy

Nan Cheng et al.

Summary: The study identified the correlation between B7-H3 high-expressing TAMs and TNBC progression, suggesting the potential of B7-H3 as a promising target in clinical TNBC treatment. Targeting blockade of B7-H3 improved tumor vasculature disorder and enhanced chemotherapy and PD-1 therapy efficacy.

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B7-H3: An Attractive Target for Antibody-based Immunotherapy

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PD-L1 Glycosylation and Its Impact on Binding to Clinical Antibodies

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miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1/NF-κB/B7-H3/TNF-α axis

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Cell-surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery

Dalia Haydar et al.

Summary: The study identified that B7-H3 and GD2 are highly expressed CAR target antigens in different pediatric brain tumor types, while other antigens have lower expression. High-grade gliomas expressed HLA class I, but other tumor subtypes had lower detectable expression. B7-H3 was chosen as the target for CAR T-cell therapy, showing promising antitumor activity in experiments.

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Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice

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Gastric Carcinomas with Stromal B7-H3 Expression Have Lower Intratumoural CD8+T Cell Density

Dita Ulase et al.

Summary: This study evaluated the spatial relationship between B7-H3 and CD8+ T cells in gastric cancer, finding that tumors with high B7-H3 expression showed significant differences in distribution of CD8+ T cells, suggesting a potential role of B7-H3 in tumor evasion of immune response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

ELK1 Promotes Epithelial-Mesenchymal Transition and the Progression of Lung Adenocarcinoma by Upregulating B7-H3

Ting-ting Yu et al.

Summary: This study reveals that ELK1 is highly expressed in LUAD and promotes cancer cell proliferation, invasion, migration, and EMT through upregulation of B7-H3, suggesting it as a potential prognostic marker and therapeutic target for LUAD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

Targeting Radiation-Resistant Prostate Cancer Stem Cells by B7-H3 CAR T Cells

Yida Zhang et al.

Summary: FIR significantly upregulates B7-H3 expression on RT-resistant PCSCs and bulk cells, leading to potent cytotoxicity of B7-H3 CAR T cells to FIR-treated PCSCs, and significantly improved antitumor efficacy in mice.

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Article Oncology

Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer

Gulanbar Amori et al.

Summary: High B7-H3 expression in diagnostic biopsy specimens is independently associated with high disease-specific mortality and overall mortality rates in patients with metastatic prostate cancer. Therefore, tumor B7-H3 expression in diagnostic biopsy specimens may serve as a useful biomarker for identifying highly aggressive metastatic prostate cancer.

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Article Cell Biology

B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction

Younseo Oh et al.

Summary: B7-H3 has been found to be highly expressed in mature osteoclasts, and deficiency of B7-H3 inhibits osteoclastogenesis in human osteoclast precursors by upregulating IFN signaling and IFN-inducible genes. Pharmacological inhibition and knockdown experiments can reverse the B7-H3 deficiency-mediated suppression of osteoclastogenesis.

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Article Biochemistry & Molecular Biology

B7-H3, Negatively Regulated by miR-128, Promotes Colorectal Cancer Cell Proliferation and Migration

Xiaomao Hu et al.

Summary: B7-H3 is upregulated in colorectal cancer tissues and cell lines, and it promotes the proliferation and migration of CRC cells. Its expression is negatively regulated by miR-128 in CRC.

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Article Cell & Tissue Engineering

CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

Cheng Wang et al.

Summary: Cancer stem cells (CSCs) evade immune surveillance by upregulating the immune checkpoint molecule CD276, but can be eliminated by anti-CD276 antibodies, inhibiting tumor growth and lymph node metastases. Targeting CD276 may reduce CSCs in head and neck squamous cell carcinoma (HNSCC).

CELL STEM CELL (2021)

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Article Biotechnology & Applied Microbiology

Expression characteristic of 4Ig B7-H3 and 2Ig B7-H3 in acute myeloid leukemia

Wei Zhang et al.

Summary: The study found that 2Ig mRNA and total B7-H3 membrane protein in AML may have potential diagnostic value, with high expression indicating worse overall survival. The expression of 4Ig and 2Ig was found to be methylation-independent in AML.

BIOENGINEERED (2021)

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Article Oncology

Overexpression of B7-H3 Is Associated With Poor Prognosis in Laryngeal Cancer

Yixuan Li et al.

Summary: The study revealed that overexpression of B7-H3 in laryngeal squamous cell carcinoma is associated with clinical and pathological characteristics, serving as a potential biomarker for poor prognosis and a therapeutic target in LSCC.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma

Cheng Long et al.

Summary: This study identified B7-H3 as a potential target for CAR-T cell therapies against skull base chordomas. Immunohistochemical analysis of clinical samples revealed positive expression of B7-H3 in a subset of chordoma samples. B7-H3 targeted CAR-T cells demonstrated significant antitumor effects in vitro, including suppression of tumor spheroid formation, CAR-T cell activation, and cytokine secretion.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

B7-H3 suppresses doxorubicin-induced senescence-like growth arrest in colorectal cancer through the AKT/TM4SF1/SIRT1 pathway

Ruoqin Wang et al.

Summary: The study found that knocking down B7-H3 promoted cellular senescence induced by low-dose doxorubicin, while overexpression of B7-H3 inhibited it. Further analysis revealed that B7-H3 prevented cellular senescence and growth arrest through the AKT/TM4SF1/SIRT1 pathway, and targeting this pathway might be a new strategy for promoting cellular senescence during drug treatment in colorectal cancer.

CELL DEATH & DISEASE (2021)

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Article Neurosciences

The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role

Marina Digregorio et al.

Summary: This study identified a subpopulation of GBM cells (SVZ-GBM cells) that have the ability to escape treatment and contribute to tumor recurrence. The protein B7-H3 was found to be specifically expressed by SVZ-GBM cells and may play a crucial role in GBM aggressiveness and recurrence.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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Review Cell Biology

Glycosylation of Immune Receptors in Cancer

Ruoxuan Sun et al.

Summary: Evasion of host immune surveillance is a hallmark of cancer, and immune checkpoint therapy aims to eliminate cancer progression by reprogramming the antitumor immune response. Understanding the impact of protein glycosylation on immune function will drive the rational development of future cancer diagnostics and therapeutic strategies.

CELLS (2021)

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Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Immunology

Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer

Zheng-Yan Li et al.

Summary: In gastric cancer tumors, neutrophils expressing CD54 and B7-H3 are closely associated with changes in GM-CSF levels, activating through the JAK-STAT3 signaling pathway. B7-H3+ neutrophils may potentially serve as biomarkers in gastric cancer, increasing with tumor progression and predicting overall survival.

CLINICAL IMMUNOLOGY (2021)

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Review Oncology

Cancer and immunotherapy: a role for microbiota composition

Fiona Pham et al.

Summary: The composition of gut microbiota may influence patients' response to cancer treatment, especially immune checkpoint blockers (ICBs). Modulating microbiota composition in patients could enhance the efficacy of ICBs or mitigate their toxicities, leading to the emergence of interesting complementary treatment strategies.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Medicine, Research & Experimental

A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity

Chin-Cheng Lee et al.

Summary: Through analysis, CD276 was identified as a risk gene in several cancers, showing a positive correlation with NK cell infiltration. Overexpression of miR-29c-3p restored CD276-reduced NK cell cytotoxicity. The negative regulatory loop involving CD276, Myc, and miR-29c-3p plays a significant role in influencing cancer cells against NK cell cytotoxicity.

LIFE SCIENCES (2021)

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Article Multidisciplinary Sciences

A membrane protein display platform for receptor interactome discovery

Shengya Cao et al.

Summary: Cell surface receptors play a critical role in cell signaling and constitute a significant portion of human genes. A new method based on extracellular vesicles has been developed to detect receptor-ligand interactions in membranes, showcasing broad applicability and enhanced detection capability. This platform bypasses the need for membrane protein purification and allows for characterization of interactomes for any cell surface-expressed target in its native state.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Endocrinology & Metabolism

Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis

Xiaoyan Qin et al.

Summary: The study demonstrated that immune checkpoint proteins B7-H2, B7-H3, B7-H4, and PD-L2 are upregulated in adenomyosis tissues, and their expression is downregulated with mifepristone treatment. These findings indicate the involvement of B7 immunomodulatory molecules in the pathophysiology of adenomyosis.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)

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Article Multidisciplinary Sciences

CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1

Sibel Durlanik et al.

Summary: CD276, a potential immune checkpoint family member, is expressed in over 70% of colorectal, prostate, ovarian, pancreatic, and breast cancer specimens, with high expression correlating with poor clinical prognosis. Lack of information on CD276 function and interaction partners hinders its rigorous evaluation as a therapeutic target in oncology. Experimental data suggest that tumor-expressed CD276 plays a role in macrophage recruitment and regulation of the extracellular matrix, while macrophage-expressed CD276 triggers inhibitory signaling networks.

SCIENTIFIC REPORTS (2021)

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Review Immunology

B7-H3/CD276: An Emerging Cancer Immunotherapy

Wu-Tong Zhou et al.

Summary: B7-H3 protein, overexpressed in tumor tissues and showing limited expression in normal tissues, is a promising target for cancer immunotherapy due to its involvement in tumor microenvironment shaping and development. Numerous B7-H3-based immunotherapy strategies have demonstrated potent antitumor activity and acceptable safety profiles in preclinical models.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Roxane R. Lavoie et al.

Summary: The study identified B7-H3 as a major immunoregulatory molecule expressed in the majority of rhabdomyosarcoma tumors, while being minimally expressed in normal tissues. Depletion of B7-H3 was associated with increased immune cell killing activity against tumor cells and decreased CD8 T-cell density. This suggests that targeting B7-H3 may be a promising strategy for developing new immunotherapies for the treatment of rhabdomyosarcoma.

CANCERS (2021)

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Super-Enhancer Induced IL-20RA Promotes Proliferation/Metastasis and Immune Evasion in Colorectal Cancer

Dingye Yu et al.

Summary: The study identified a novel oncogenic super-enhancer-regulated gene IL-20RA in colorectal cancer (CRC), demonstrating its crucial role in cell proliferation and immune escape. Inhibition of super-enhancers suppressed tumor cell growth and IL-20RA expression, providing insights into oncogenic super-enhancer contributions to CRC progression.

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CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines

Jianfeng Shi et al.

Summary: The study demonstrates a positive correlation between the expression of CD276 and the amount of sphere-forming cells in HeLa cell lines. Overexpression of CD276 inhibits sphere formation and cell viability, while downregulation of CD276 has the opposite effect. Additionally, CD276 contributes to chemotherapy resistance in the cell line.

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B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression

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Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma

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MicroRNA-199a Inhibits Cell Proliferation, Migration, and Invasion and Activates AKT/mTOR Signaling Pathway by Targeting B7-H3 in Cervical Cancer

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A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155

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B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models

Benjamin B. Kasten et al.

NUCLEAR MEDICINE AND BIOLOGY (2017)

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Article Oncology

B7-H3 promotes the proliferation, migration and invasiveness of cervical cancer cells and is an indicator of poor prognosis

Yi Li et al.

ONCOLOGY REPORTS (2017)

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Article Oncology

B7-H3 promotes gastric cancer cell migration and invasion

Yecheng Li et al.

ONCOTARGET (2017)

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Article Oncology

B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway

Yuchao Li et al.

JOURNAL OF CANCER (2017)

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Article Oncology

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

Sangbin Lim et al.

CANCER RESEARCH (2016)

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Article Oncology

Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy

Elodie Picarda et al.

CLINICAL CANCER RESEARCH (2016)

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Article Oncology

Therapy to target renal cell carcinoma using 131I-labeled B7-H3 monoclonal antibody

Gongcheng Wang et al.

ONCOTARGET (2016)

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Article Multidisciplinary Sciences

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

Valentina Cappello et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice

Linxiang Lan et al.

EMBO JOURNAL (2015)

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Article Biochemistry & Molecular Biology

ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer

Pei Zhang et al.

FEBS LETTERS (2015)

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Article Multidisciplinary Sciences

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Jung-Tsu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Oncology

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c

M. K. Nygren et al.

BRITISH JOURNAL OF CANCER (2014)

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Article Oncology

Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder

E. Xylinas et al.

EJSO (2014)

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Editorial Material Biotechnology & Applied Microbiology

The immune checkpoint inhibitors: where are we now?

Rachel Webster

NATURE REVIEWS DRUG DISCOVERY (2014)

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Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Oncology

B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients

Aparajita Baral et al.

ONCOLOGY LETTERS (2014)

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Review Immunology

The IL-20 subfamily of cytokines - from host defence to tissue homeostasis

Sascha Rutz et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3

Jun Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Review Hematology

The role of B7 family molecules in hematologic malignancy

Paul Greaves et al.

BLOOD (2013)

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Review Pathology

The significance of the senescence pathway in breast cancer progression

Rahmawati Pare et al.

JOURNAL OF CLINICAL PATHOLOGY (2013)

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Article Biochemistry & Molecular Biology

Structure and T Cell Inhibition Properties of B7 Family Member, B7-H3

Vladimir Vigdorovich et al.

STRUCTURE (2013)

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Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

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Article Oncology

B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer

Vibeke Anett Ingebrigtsen et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Review Biotechnology & Applied Microbiology

Cancer stem cells and drug resistance: the potential of nanomedicine

Serguei Vinogradov et al.

NANOMEDICINE (2012)

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Review Cell Biology

Senescence: a new weapon for cancer therapy

Juan Carlos Acosta et al.

TRENDS IN CELL BIOLOGY (2012)

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Article Oncology

B7-H3 expression in gastric cancer: A novel molecular blood marker for detecting circulating tumor cells

Takaaki Arigami et al.

CANCER SCIENCE (2011)

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Article Urology & Nephrology

B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression

Hexing Yuan et al.

JOURNAL OF UROLOGY (2011)

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Article Oncology

B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation

Hao Liu et al.

MOLECULAR CANCER THERAPEUTICS (2011)

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Article Multidisciplinary Sciences

Origination of New Immunological Functions in the Costimulatory Molecule B7-H3: The Role of Exon Duplication in Evolution of the Immune System

Jing Sun et al.

PLOS ONE (2011)

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Article Surgery

B7-H3 Ligand Expression by Primary Breast Cancer and Associated With Regional Nodal Metastasis

Takaaki Arigami et al.

ANNALS OF SURGERY (2010)

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Review Immunology

B7-H3 and Its Role in Antitumor Immunity

Martin Loos et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2010)

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Article Oncology

Cancer Stem Cells and Self-renewal

Catherine Adell O'Brien et al.

CLINICAL CANCER RESEARCH (2010)

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Article Multidisciplinary Sciences

The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

Yingzi Wang et al.

SCIENCE (2010)

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Article Oncology

Clinical importance of B7-H3 expression in human pancreatic cancer

I. Yamato et al.

BRITISH JOURNAL OF CANCER (2009)

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Article Immunology

B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction

Judith Leitner et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Article Oncology

Senescence-associated exosome release from human prostate cancer cells

Brian D. Lehmann et al.

CANCER RESEARCH (2008)

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Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

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Article Oncology

Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma

Paul L. Crispen et al.

CLINICAL CANCER RESEARCH (2008)

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Review Oncology

The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion

Yih-Wen Chen et al.

CURRENT CANCER DRUG TARGETS (2008)

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Article Immunology

Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum

Guangbo Zhang et al.

IMMUNOLOGY (2008)

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Article Immunology

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

Yasuhiro Nagai et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Immunology

Interactions of T cells with fibroblast-like synoviocytes: Role of the B7 family costimulatory ligand B7-H3

Chinh N. Tran et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

Masaaki Hashiguchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Oncology

B7-H3 and B7-H4 expression in non-small-cell lung cancer

Yuping Sun et al.

LUNG CANCER (2006)

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Review Multidisciplinary Sciences

Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouyssegur et al.

NATURE (2006)

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Review Biotechnology & Applied Microbiology

The B7 family of immune-regulatory ligands

M Collins et al.

GENOME BIOLOGY (2005)

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Article Immunology

B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells

LQ Luo et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Biotechnology & Applied Microbiology

Antibody-targeted radiation cancer therapy

DE Milenic et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

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Article Immunology

Characterization of mouse and human B7-H3 genes

MY Sun et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Immunology

B7-H3:: A costimulatory molecule for T cell activation and IFN-γ production

AI Chapoval et al.

NATURE IMMUNOLOGY (2001)

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