Angiotensin converting enzyme 2 gene expression and markers of oxidative stress are correlated with disease severity in patients with COVID-19

Article Virology

Total antioxidant capacity as a marker of severity of COVID-19 infection: Possible prognostic and therapeutic clinical application

Neda Yaghoubi et al.

Summary: The study found that COVID-19 patients may be more susceptible to reduced antioxidant capacity, and such variations in blood samples could be considered as a predictive marker of COVID-19 severity.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Review Cell Biology

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Endocrinology & Metabolism

Effect of colchicine on mortality in patients with COVID-19 - A systematic review and meta-analysis

Ahmad Fariz Malvi Zamzam Zein et al.

Summary: This systematic review and meta-analysis suggests an association between colchicine and reduced mortality in patients with COVID-19, although the analysis of randomized trials did not show a significant effect of colchicine on mortality.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2022)

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Article Endocrinology & Metabolism

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19

Joshua R. Cook et al.

Summary: SARS-CoV-2 virus primarily uses ACE2 as its main receptor, associated with the renin-angiotensin system. ACE2 deficiency may contribute to the multisystem dysfunction of COVID-19, leading to angiotensin imbalance.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2022)

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Review Hematology

Renal replacement therapy for critically ill patients with COVID-19-associated acute kidney injury: A review of current knowledge

Rasha Samir Shemies et al.

Summary: The incidence of AKI among COVID-19 patients is increasing, but studies on AKI treated with RRT remain limited. Further research is needed on the pathophysiological mechanisms, treatment approaches, and indications for RRT in the context of COVID-19.

THERAPEUTIC APHERESIS AND DIALYSIS (2022)

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Article Biochemistry & Molecular Biology

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

Vignesh Mariappan et al.

Summary: This study investigated the plasma ACE2 levels during the early phase of COVID-19 infection and found a significant increase in sACE2 in severe cases. There was also a strong positive correlation between sACE2 and D-dimer, suggesting the potential of sACE2 as a clinical biomarker for disease outcome prediction.

BIOCHIMIE (2022)

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Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Peripheral Vascular Disease

Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19

Marina Rieder et al.

Summary: In this study, researchers did not find significant differences in serum levels of ACE2, angiotensin II, aldosterone, RAAS activity surrogate parameters such as serum potassium, and blood pressure between COVID-19 patients and the control group.

AMERICAN JOURNAL OF HYPERTENSION (2021)

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Review Pharmacology & Pharmacy

Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

Cristina Vieira et al.

Summary: The review explores the connection between the renin-angiotensin system (RAS) components, the immune system, and COVID-19 pathophysiology, highlighting the downregulation of membrane-bound ACE2 as a key factor in immune dysfunction and patient outcomes.

CURRENT DRUG TARGETS (2021)

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Article Immunology

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

Dounia Darif et al.

Summary: This article summarizes the pathogenesis of cytokine release syndrome (CRS) in patients with COVID-19, the potential causes of inflammatory responses, and the clinical outcomes of this phenomenon in severe cases.

MICROBIAL PATHOGENESIS (2021)

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Letter Hematology

Mean Platelet Volume Predicts Severe COVID-19 Illness

Giuseppe Lippi et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2021)

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Review Immunology

Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm

Ali A. Rabaan et al.

Summary: COVID-19, caused by SARS-CoV-2, is a severe pandemic with unknown complications. The disease leads to a cytokine storm and severe complications like multiple organ failure, acute respiratory distress, and pneumonia. Elderly individuals are at higher risk of complications, while the survival rate is relatively higher compared to other chronic diseases.

VACCINES (2021)

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Article Medicine, Research & Experimental

Changes in oxidative markers in COVID-19 patients

Fereshteh Mehri et al.

Summary: This study found that oxidative stress markers are significantly elevated in Covid-19 patients, which may play an important role in the disease development process.

ARCHIVES OF MEDICAL RESEARCH (2021)

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Article Immunology

Potential biomarkers for the early prediction of SARS-COV-2 disease outcome

Vignesh Mariappan et al.

Summary: The current pandemic caused severe damage across various sectors globally, with unclear disease pathogenesis leading to unpredictable clinical outcomes. Developing prognostic biomarkers for predicting COVID-19 patient condition is crucial for efficient patient management.

MICROBIAL PATHOGENESIS (2021)

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Review Oncology

Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling

Zilan Zhu et al.

Summary: COVID-19 and lung cancer have dysregulated signaling pathways, with ROS playing a crucial role. The activation of inflammation pathways affects the development of both diseases, while the NRF2 pathway shows opposite trends between them. The modulation of ROS signaling pathways may alleviate the potentially mutual impacts between COVID-19 and lung cancer patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Infectious Diseases

Evaluation of oxidative stress level: total antioxidant capacity, total oxidant status and glutathione activity in patients with COVID-19

B. Karkhanei et al.

Summary: COVID-19 is a dangerous global pandemic with high morbidity and mortality. The study found that levels of oxidative stress and antioxidant indices are related to disease severity and can be used to predict patient outcomes. Antioxidant agents may be effective therapeutic strategies for hospitalised COVID-19 patients with elevated oxidative stress levels.

NEW MICROBES AND NEW INFECTIONS (2021)

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Article Medical Laboratory Technology

Mean platelet volume/platelet count ratio predicts severe pneumonia of COVID-19

Qingyang Zhong et al.

Summary: High MPR level is an independent risk factor for severe pneumonia in patients with COVID-19.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Medicine, General & Internal

Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria

Yahaya Muhammad et al.

Summary: The study found that COVID-19 patients have lower levels of antioxidants and higher levels of oxidative stress markers, making them more susceptible to the negative effects of free radicals.

SAGE OPEN MEDICINE (2021)

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Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

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Review Medicine, Research & Experimental

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

Livan Delgado-Roche et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Review Respiratory System

Melatonin for the treatment of sepsis: the scientific rationale

Ruben Manuel Luciano Colunga Biancatelli et al.

JOURNAL OF THORACIC DISEASE (2020)

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Letter Gastroenterology & Hepatology

Bilirubin levels in patients with mild and severe Covid-19: A pooled analysis

Panagiotis Paliogiannis et al.

LIVER INTERNATIONAL (2020)

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Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

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Article Multidisciplinary Sciences

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

Muhammad Adnan Shereen et al.

JOURNAL OF ADVANCED RESEARCH (2020)

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Article Medicine, General & Internal

ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)?

Pasquale Pagliaro et al.

FRONTIERS IN MEDICINE (2020)

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Review Medicine, General & Internal

ACE2 and COVID-19 and the resulting ARDS

Xiaoqing Zhang et al.

POSTGRADUATE MEDICAL JOURNAL (2020)

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Article Pharmacology & Pharmacy

Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19

Mohamed A. El-Missiry et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Angiotensin-converting enzyme 2: A protective factor in regulating disease virulence of SARS-COV-2

Vignesh Mariappan et al.

IUBMB LIFE (2020)

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Review Biochemistry & Molecular Biology

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

Natalia de las Heras et al.

ANTIOXIDANTS (2020)

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Article Medicine, General & Internal

Bilirubin Levels as Potential Indicators of Disease Severity in Coronavirus Disease Patients: A Retrospective Cohort Study

Zeming Liu et al.

FRONTIERS IN MEDICINE (2020)

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Letter Public, Environmental & Occupational Health

COVID-19 infection and oxidative stress: an under-explored approach for prevention and treatment?

Marie-Pierrette Ntyonga-Pono

PAN AFRICAN MEDICAL JOURNAL (2020)

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Review Cell Biology

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Aleksandra Korniluk et al.

MEDIATORS OF INFLAMMATION (2019)

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Review Virology

Implications of oxidative stress on viral pathogenesis

Fernanda Caetano Camini et al.

ARCHIVES OF VIROLOGY (2017)

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Editorial Material Cell Biology

Oxidative Stress in Infection and Consequent Disease

Alexander V. Ivanov et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Article Surgery

Melatonin: is it an effective antioxidant for pulmonary contusion?

Serife Ozdinc et al.

JOURNAL OF SURGICAL RESEARCH (2016)

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Article Multidisciplinary Sciences

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

L. C. Oostwoud et al.

SCIENTIFIC REPORTS (2016)

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Article Critical Care Medicine

Association between serum total antioxidant capacity and mortality in severe septic patients

Leonardo Lorente et al.

JOURNAL OF CRITICAL CARE (2015)

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Article Biochemistry & Molecular Biology

Reactive Oxygen Species Induce Antiviral Innate Immune Response through IFN-λ Regulation in Human Nasal Epithelial Cells

Hyun Jik Kim et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

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Article Cell Biology

Vascular Endothelial Cadherin Expression in Lung Specimens of Patients with Sepsis-Induced Acute Respiratory Distress Syndrome and Endothelial Cell Cultures

Martina C. Herwig et al.

PATHOBIOLOGY (2013)

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Article Microbiology

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

Sander van Boheemen et al.

MBIO (2012)

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Review Cell Biology

Crosstalk of reactive oxygen species and NF-kappa B signaling

Michael J. Morgan et al.

CELL RESEARCH (2011)

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Article Biochemical Research Methods

Analyzing real-time PCR data by the comparative C-T method

Thomas D. Schmittgen et al.

NATURE PROTOCOLS (2008)

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Article Physiology

Transcriptional responses to intermittent hypoxia

Jayasri Nanduri et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2008)

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Article Toxicology

Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard

Muharrem Ucar et al.

TOXICOLOGY LETTERS (2007)

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Letter Critical Care Medicine

Serum uric acid, creatinine, and the assessment of antioxidant capacity in critical illness

Ivo Giovannini et al.

CRITICAL CARE (2006)

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Article Critical Care Medicine

Serum total antioxidant capacity reflects severity of illness in patients with severe sepsis

Chia-Chang Chuang et al.

CRITICAL CARE (2006)

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Article Biochemistry & Molecular Biology

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

K Kuba et al.

NATURE MEDICINE (2005)

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Article Medicine, General & Internal

Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study

JP Neoptolemos et al.

LANCET (2000)

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Angiotensin converting enzyme 2 gene expression and markers of oxidative stress are correlated with disease severity in patients with COVID-19

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