4.5 Article

Liver impact of growth hormone (GH) intermittent treatment during the growth period in mice*

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

22-kD growth hormone-induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation

Wei Zheng et al.

Summary: The study explored the cellular behavior and properties of growth hormone (GH) and its receptor in mesenchymal stem cells (MSCs), revealing that nuclear-targeted GHR drives cell proliferation through a specific signaling pathway. This research has laid an important foundation for further investigation into the regulatory effects of GH on MSCs.

BIOFACTORS (2022)

Review Pediatrics

The history, physiology and treatment safety of growth hormone

Anders Tidblad

Summary: Growth hormone treatment was initially introduced in the 1950s for growth disturbances and metabolic abnormalities, and has since expanded to be used for various conditions associated with short stature. However, there are long-term risks such as mortality, cardiovascular morbidity, and cancer, highlighting the importance of continuous follow-up to enhance our understanding of long-term treatment safety.

ACTA PAEDIATRICA (2022)

Review Endocrinology & Metabolism

Early Life Interventions Can Shape Aging

Andrzej Bartke et al.

Summary: It is well documented that the environment during fetal development and postnatal period can significantly influence adult phenotype, age-related traits, and risk of chronic disease. Researchers have found that early life hormonal interventions, such as growth hormone replacement therapy, can impact the trajectory of aging and adult metabolic characteristics in mice. Important regulatory mechanisms involving epigenetic phenomena are likely involved.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Biochemistry & Molecular Biology

Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice

Xinna Li et al.

Summary: Transient early-life growth hormone (GH) treatment can permanently alter relevant changes in adipocytes, liver, muscle, and brain in Ames dwarf mice, and restore protein levels to those seen in littermate control animals.

FASEB JOURNAL (2022)

Review Cell Biology

GHR signalling: Receptor activation and degradation mechanisms

Yash Chhabra et al.

Summary: This review summarizes the current knowledge on the activation, regulation, and downstream signaling of the GH receptor, focusing on the activation of SRC family kinases by GH and the different degradation mechanisms that can regulate GHR availability. Further studies on this area are warranted considering its role in tumor progression.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

Review Cell Biology

Central Regulation of Metabolism by Growth Hormone

Jose Donato et al.

Summary: Growth hormone plays a crucial role in regulating metabolism in the brain, affecting food intake, energy expenditure, blood sugar levels, and neuroendocrine changes. It acts as a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis.

CELLS (2021)

Review Endocrinology & Metabolism

GH Resistance Is a Component of Idiopathic Short Stature: Implications for rhGH Therapy

Martin O. Savage et al.

Summary: Idiopathic short stature (ISS) is a term used for short children without a known cause; research on GH resistance is important for potentially misclassified children with mild GH resistance.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling

Lorena Gonzalez et al.

Summary: The interaction between EGFR and GH in the liver plays a significant role in the development and progression of liver tumors, with factors such as exposure to supraphysiological GH levels and the pattern of GH administration being important variables to consider.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Review Cell Biology

Effect of growth hormone on insulin signaling

Rita Sharma et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Growth Hormone Receptor Regulation in Cancer and Chronic Diseases

Ger J. Strous et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver

Maria L. Bacigalupo et al.

ENDOCRINE CONNECTIONS (2019)

Review Endocrinology & Metabolism

Risk of cancer in patients treated with recombinant human growth hormone in childhood

Stefano Cianfarani

ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2019)

Article Pharmacology & Pharmacy

A partnership with the proteasome; the destructive nature of GSK3

Holly Robertson et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Endocrinology & Metabolism

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

Farhad Dehkhoda et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

Analysis of Different Approaches for the Selection of Reference Genes in RT-qPCR Experiments: A Case Study in Skeletal Muscle of Growing Mice

Veronica G. Piazza et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Endocrinology & Metabolism

Growth Hormone Control of Hepatic Lipid Metabolism

Zhongbo Liu et al.

DIABETES (2016)

Article Cell Biology

Traditional and novel aspects of the metabolic actions of growth hormone

Mark A. Sperling

GROWTH HORMONE & IGF RESEARCH (2016)

Article Endocrinology & Metabolism

GH/STAT5 signaling during the growth period in livers of mice overexpressing GH

Carolina S. Martinez et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)

Article Cell Biology

Identifying growth hormone-regulated enhancers in the Igf1 locus

Damir Alzhanov et al.

PHYSIOLOGICAL GENOMICS (2015)

Article Endocrinology & Metabolism

GH administration patterns differently regulate epidermal growth factor signaling

Maria E. Diaz et al.

JOURNAL OF ENDOCRINOLOGY (2014)

Article Medicine, Research & Experimental

MYC and Transcription Elongation

Peter B. Rahl et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)

Article Cell Biology

Growth hormone STAT5-mediated signaling and its modulation in mice liver during the growth period

Carolina S. Martinez et al.

GROWTH HORMONE & IGF RESEARCH (2013)

Review Endocrinology & Metabolism

Growth hormone and cancer: an update on progress

Jo K. Perry et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2013)

Article Endocrinology & Metabolism

GH Receptor Plays a Major Role in Liver Regeneration through the Control of EGFR and ERK1/2 Activation

Amal Zerrad-Saadi et al.

ENDOCRINOLOGY (2011)

Article Endocrinology & Metabolism

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism

Johanna L. Barclay et al.

ENDOCRINOLOGY (2011)

Review Biochemistry & Molecular Biology

The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins

HyeonJoo Cheon et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2011)

Article Endocrinology & Metabolism

The Intricate Role of Growth Hormone in Metabolism

Archana Vijayakumar et al.

Frontiers in Endocrinology (2011)

Article Gastroenterology & Hepatology

Cyclin D1 regulates hepatic estrogen and androgen metabolism

Lisa K. Mullany et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Endocrinology & Metabolism

GH modulates hepatic epidermal growth factor signaling in the mouse

Lorena Gonzalez et al.

JOURNAL OF ENDOCRINOLOGY (2010)

Article Endocrinology & Metabolism

Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation

Johanna G. Miquet et al.

JOURNAL OF ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

The rapid activation of protein synthesis by growth hormone requires signaling through mTOR

Amanda A. Hayashi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Gastroenterology & Hepatology

Estrogen-induced proliferation in cultured hepatocytes involves cyclin D1, P21CIP1 and P27KIP1

M Barone et al.

DIGESTIVE DISEASES AND SCIENCES (2006)

Article Endocrinology & Metabolism

In vivo regulation of growth hormone-stimulated gene transcription by STAT5b

J Woelfle et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Review Cell Biology

Proliferating cell nuclear antigen (PCNA):: a dancer with many partners

G Maga et al.

JOURNAL OF CELL SCIENCE (2003)

Article Biochemistry & Molecular Biology

Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

CJ Nelsen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biochemistry & Molecular Biology

Making decisions through Myc

S Nasi et al.

FEBS LETTERS (2001)