☆ 4.6 Article

Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

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Article Oncology

A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma

Yingkai Hong et al.

Summary: A prognostic 12-gene signature related to ferroptosis was established and confirmed to be a valuable independent predictor for overall survival in clear cell renal cell carcinoma. Enrichment analysis showed a correlation with iron metabolism and tumor immunity in ccRCC.

BMC CANCER (2021)

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Article Biochemistry & Molecular Biology

Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury

Yinyin Ye et al.

Summary: PKM2 plays a role in fibroblast activation in AKI, and its loss impairs fibroblast proliferation, promotes tubular epithelial cell death, and may worsen AKI by blocking HGF signal activation. Targeting PKM2 expression could be a novel strategy for treating AKI.

FASEB JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

Shuo Ni et al.

Summary: This study demonstrates the involvement of ferroptosis in osteoclast differentiation induced by RANKL, with mechanisms including iron-starvation response and ferritinophagy. It also reveals the impact of HIF-1 alpha on ferritinophagy and autophagy flux under hypoxia conditions. Ferroptosis induction in osteoclasts through targeting HIF-1 alpha and ferritin may offer a novel therapeutic approach for osteoporosis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Oncology

CLTRN, Regulated by NRF1/RAN/DLD Protein Complex, Enhances Radiation Sensitivity of Hepatocellular Carcinoma Cells Through Ferroptosis Pathway

Yin Yuan et al.

Summary: CLTRN is a crucial regulator of radiation sensitivity in hepatocellular carcinoma, associated with ferroptosis and potentially serving as a novel therapeutic target or prognostic marker in HCC treatment.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Endocrinology & Metabolism

The role of regulated necrosis in endocrine diseases

Wulf Tonnus et al.

Summary: Research on basic cell death has shown that most pathophysiologically significant cell death is necrotic in nature, while regulated necrosis can take different forms such as necroptosis, pyroptosis, and ferroptosis. Necrosis leads to an immune response by releasing damage-associated molecular patterns, and thus the consequences of regulated necrosis in the endocrine environment are specific.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Neurosciences

Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Yongfa Zhang et al.

Summary: Ferroptosis is a unique form of regulated cell death characterized by intracellular iron overload, and it has been shown to play important roles in various cancers as well as in the progression of cerebral stroke.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Cell Biology

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

Jiashuo Zheng et al.

Summary: Sorafenib does not induce ferroptosis and only a subset of tumor cell lines experience ferroptosis in response to system x(c)(-) inhibitors. These findings suggest that different tumor cells exhibit varying responses to ferroptosis.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Wulf Tonnus et al.

Summary: This study demonstrates the role of ferroptosis in acute kidney injury and how dysfunction of Gpx4 can hypersensitize mice to tubular damage. The researchers developed a dual inhibitor targeting RIPK1 and ferroptosis, which improved survival rates in mouse models of acute kidney injury.

NATURE COMMUNICATIONS (2021)

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Article Genetics & Heredity

Identification and Validation of a Ferroptosis-Related Long Non-coding RNA Signature for Predicting the Outcome of Lung Adenocarcinoma

Zhiyuan Zheng et al.

Summary: By studying ferroptosis-related long non-coding RNAs, we established a novel signature that can accurately predict the outcome of LUAD and is associated with the immune response.

FRONTIERS IN GENETICS (2021)

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Article Oncology

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma

Bowen Li et al.

Summary: The study revealed that CISD2 plays a crucial role in sorafenib resistance in HCC, as its knockdown promoted ferroptosis in resistant cells. Additionally, autophagy induced by CISD2 knockdown was associated with ferroptosis in HCC cells.

FRONTIERS IN ONCOLOGY (2021)

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Article Genetics & Heredity

Ferroptosis-Related Genes in Lung Adenocarcinoma: Prognostic Signature and Immune, Drug Resistance, Mutation Analysis

Ziyuan Ren et al.

Summary: This study established a 15-gene prognostic signature based on ferroptosis-related genes for lung adenocarcinoma (LUAD) and validated its predictive ability, providing nomograms for clinical reference. Functional analysis revealed associations between ferroptosis and cell cycle, cell metabolism, and immune pathways. Pan-cancer analysis demonstrated the heterogeneity of these genes among different cancer types. Ten genes were identified as potential targets for further research, with KRAS and PGD suggested as novel immunotherapy biomarkers.

FRONTIERS IN GENETICS (2021)

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Article Biotechnology & Applied Microbiology

Transferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1/PTEN induced kinase 1/acyl-CoA synthetase long chain family member 4 signaling

Lingzhi Zhang et al.

Summary: This study investigated the role of iron metabolism in PCOS and identified the potential therapeutic target of TFRC/NOX1/PINK1/ACSL4 signaling pathway for folliculogenesis.

BIOENGINEERED (2021)

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Review Physiology

Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism

Fei Deng et al.

Summary: Regulated cell death (RCD), which is distinct from accidental cell death, is a well-controlled programmed cell death process with defined pathological mechanisms. The term RCD encompasses various types of cell death, some of which have been implicated in the pathogenesis of acute kidney injury (AKI), such as cisplatin-induced AKI.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The essential elements of Alzheimer's disease

Peng Lei et al.

Summary: Despite numerous phase 3 clinical trials targeting amyloid plaque in AD treatment, their effectiveness remains uncertain. This study highlights the importance of other neurochemical abnormalities in the AD brain as potential therapeutic targets, focusing on elementomic signatures of essential elements like iron, copper, zinc, and selenium. Revisiting discoveries in the AD field may offer new insights into pathogenesis and therapeutic strategies.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

Scott Ayton et al.

MOLECULAR PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

The Effect of Abnormal Iron Metabolism on Osteoporosis

Jingmin Che et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Review Neurosciences

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

Paul J. Derry et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Article Pathology

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

Zhou Zhou et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

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Review Biochemistry & Molecular Biology

Regulated Necrosis in Pulmonary Disease A Focus on Necroptosis and Ferroptosis

Shunsuke Minagawa et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

Regina Brigelius-Flohe et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Review Biochemistry & Molecular Biology

The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes

Natticha Sumneang et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

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Review Obstetrics & Gynecology

Endometriosis: The Role of Iron Overload and Ferroptosis

Shu-Wing Ng et al.

REPRODUCTIVE SCIENCES (2020)

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Article Multidisciplinary Sciences

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism

Shashipavan Chillappagari et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Ferroptosis is involved in alcohol-induced cell deathin vivoandin vitro

Chun-Yu Liu et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020)

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Article Hematology

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Rushdia Zareen Yusuf et al.

BLOOD (2020)

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Article Environmental Sciences

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

Pan Meng et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Review Environmental Sciences

The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: A review of in vivo and in vitro studies

Jian Zhang

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020)

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Article Biochemical Research Methods

Time Course of Changes in Sorafenib-Treated Hepatocellular Carcinoma Cells Suggests Involvement of Phospho-Regulated Signaling in Ferroptosis Induction

Emily G. Werth et al.

PROTEOMICS (2020)

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Article Cell Biology

Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction

Isabel Weigand et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells

Yuxue Shang et al.

CELLULAR SIGNALLING (2020)

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Review Biochemistry & Molecular Biology

Ferroptosis in Liver Diseases: An Overview

Martina Maria Capelletti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Saponin Formosanin C-Induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells

Pin-Lun Lin et al.

ANTIOXIDANTS (2020)

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Article Cell Biology

Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5

Zhiqian Liu et al.

CELL DEATH DISCOVERY (2020)

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Article Medicine, Research & Experimental

Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system

Mingming Jin et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Editorial Material Oncology

Lymph: (Fe)rrying Melanoma to Safety

Amanda W. Lund et al.

CANCER CELL (2020)

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Review Cell Biology

Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

Ningning Tao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Pharmacology & Pharmacy

Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice

Xi Zhao et al.

TOXICOLOGY (2020)

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Review Cell Biology

The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

Lihong Mao et al.

CELL DEATH & DISEASE (2020)

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Editorial Material Multidisciplinary Sciences

Cancer cells stock up in lymph vessels to survive

Barbara M. Gruener et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

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Review Cell Biology

Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis

Yani Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cell Biology

Computational repositioning of dimethyl fumarate for treating alcoholic liver disease

Ye Zhang et al.

CELL DEATH & DISEASE (2020)

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Article Chemistry, Medicinal

Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease

Jun Liu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Article Cell & Tissue Engineering

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

Yuchen Li et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Physiology

USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death

Shuxian Ma et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Gastroenterology & Hepatology

Programmed cell death in alcohol-associated liver disease

Tatsunori Miyata et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2020)

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Article Cell Biology

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Hongdong Ma et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Pharmacology & Pharmacy

Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis

Jingjing Liu et al.

TOXICOLOGY (2020)

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Article Oncology

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Neurosciences

Insight Into the Role of Ferroptosis in Non-neoplastic Neurological Diseases

Jianwei Lei et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Review Biochemistry & Molecular Biology

The Chemical Biology of Ferroptosis in the Central Nervous System

Rajiv R. Ratan

CELL CHEMICAL BIOLOGY (2020)

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Article Gastroenterology & Hepatology

Endocrine Diseases and the Liver: An Update

Miguel Malespin et al.

CLINICS IN LIVER DISEASE (2019)

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Review Urology & Nephrology

Regulated necrosis in kidney ischemia-reperfusion injury

Aspasia Pefanis et al.

KIDNEY INTERNATIONAL (2019)

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Review Neurosciences

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

Nuria DeGregorio-Rocasolano et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Review Cardiac & Cardiovascular Systems

y Phospholipid oxidation products in ferroptotic myocardial cell death

Aleksandra Stamenkovic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

CELL (2019)

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Article Critical Care Medicine

Radiation-Induced Lung Injury Assessment and Management

Alexander N. Hanania et al.

CHEST (2019)

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Review Oncology

Malignant Melanoma: Autoimmunity and Supracellular Messaging as New Therapeutic Approaches

Ion G. Motofei

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2019)

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Review Cell Biology

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

Milad Ashrafizadeh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Immunology

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-1

Xuan Li et al.

JOURNAL OF INFLAMMATION-LONDON (2019)

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Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

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Review Biochemistry & Molecular Biology

Cell Death in the Kidney

Giovanna Priante et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Shu-Wing Ng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma: Mechanisms of progression and immunotherapy

Yu Jiang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Multidisciplinary Sciences

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Masahiro Yoshida et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma

Yuanyang Lai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Xiaoqing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Oncology

Iron and leukemia: new insights for future treatments

Fang Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Neurosciences

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

Bin Chen et al.

BRAIN RESEARCH BULLETIN (2019)

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Article Biochemistry & Molecular Biology

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

Lianjiu Su et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

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Review Cell Biology

Emerging Role of Ferroptosis in Acute Kidney Injury

Zhaoxin Hu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

Alexia Belavgeni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

Mara Gagliardi et al.

CELL DEATH & DISEASE (2019)

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Article Cell Biology

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

Tae-Jun Park et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

Jinsen Lu et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells

Wenchuan Qi et al.

SCIENTIFIC REPORTS (2019)

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Article Biochemistry & Molecular Biology

Lipid storage and lipophagy regulates ferroptosis

Yuansong Bai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Yansheng Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Neurosciences

Ferroptosis and Its Role in Diverse Brain Diseases

Abigail Weiland et al.

MOLECULAR NEUROBIOLOGY (2019)

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Review Clinical Neurology

Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage

Jieru Wan et al.

STROKE AND VASCULAR NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

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Article Developmental Biology

Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids

Elizabeth G. Bromfield et al.

MOLECULAR HUMAN REPRODUCTION (2019)

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Article Pharmacology & Pharmacy

Tissue plasminogen activator-based nanothrombolysis for ischemic stroke

Shan Liu et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Cardiac & Cardiovascular Systems

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

Yuichi Baba et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

Bei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

ENPP2 protects cardiomyocytes from erastin-induced ferroptosis

Yu-Ting Bai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

Meiying Luo et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Cell & Tissue Engineering

Regulated Cell Death Seen through the Lens of Islet Transplantation

Antonio Bruni et al.

CELL TRANSPLANTATION (2018)

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Article Medicine, Research & Experimental

Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death

Li Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

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Article Oncology

Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines

Silvia Codenotti et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

Seema Patel

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

Xiangming Ji et al.

ONCOGENE (2018)

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Review Physiology

NEURONAL CELL DEATH

Michael Fricker et al.

PHYSIOLOGICAL REVIEWS (2018)

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Review Cell Biology

Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields

Diego Martin-Sanchez et al.

CELL DEATH & DISEASE (2018)

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Review Neurosciences

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

Jan Lewerenz et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Review Biochemistry & Molecular Biology

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

Jia-rui Wu et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Article Biochemistry & Molecular Biology

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

Kexin Zhang et al.

MOLECULAR CARCINOGENESIS (2018)

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Review Neurosciences

Iron and Alzheimer's Disease: From Pathogenesis to Therapeutic Implications

Jun-Lin Liu et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Biochemistry & Molecular Biology

Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-beta/Smad3 signaling pathway in an Nrf2-dependent manner

Chao Bian et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Physiology

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells

Oreoluwa Adedoyin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Review Cell Biology

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

Haitao Yu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

Weijun Ou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Review Neurosciences

NADPH oxidases in Parkinson's disease: a systematic review

Karim Belarbi et al.

MOLECULAR NEURODEGENERATION (2017)

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Article Biochemistry & Molecular Biology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-z Tuo et al.

MOLECULAR PSYCHIATRY (2017)

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Review Biochemistry & Molecular Biology

Ferroptosis and cell death mechanisms in Parkinson's disease

Stephanie J. Guiney et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Article Biochemistry & Molecular Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

William Sealy Hambright et al.

REDOX BIOLOGY (2017)

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Review Pharmacology & Pharmacy

Apoptosis and Acute Brain Ischemia in Ischemic Stroke

Djordje Radak et al.

CURRENT VASCULAR PHARMACOLOGY (2017)

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Article Biochemistry & Molecular Biology

The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death

Ron Shah et al.

ACS CHEMICAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells

Tao Bai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

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Article Biochemistry & Molecular Biology

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

Hua Yuan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Article Neurosciences

Meta-analysis of the association between serum iron levels and Parkinson's disease: Evidence from 11 publications

Junjie Jiao et al.

BRAIN RESEARCH (2016)

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Article Gastroenterology & Hepatology

Metallothionein-1G Facilitates Sorafenib Resistance Through Inhibition of Ferroptosis

Xiaofang Sun et al.

HEPATOLOGY (2016)

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Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

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Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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