Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s11010-023-04747-7
Keywords
Interleukin; Cytokine; Receptor; Association; Schizophrenia
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Inconsistent data were found in studies investigating the association between the IL-6/IL-6R axis and schizophrenia susceptibility. A meta-analysis showed increased IL-6 levels in plasma, serum, or CSF and decreased IL-6R levels in serum in patients under treatment. Further studies are needed to clarify the correlation between the IL-6/IL-6R axis and schizophrenia.
Studies investigating the association between IL-6/IL-6R axis and schizophrenia (SZ) susceptibility found inconsistent data. To reconcile the results, a systematic review followed by a meta-analysis was performed to assess the associations. This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of the literature was carried out in July 2022 using electronic databases PubMed, EBSCO, Science Direct, PsychInfo, and Scopus. Study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Fifty-eight studies were identified, including 4,200 SZ patients and 4,531 controls. Our meta-analysis results showed an increase of IL-6 levels in plasma, serum, or CSF and decreased IL-6R levels in serum in patients under treatment. Further studies are needed to better elucidate the correlation between the IL-6/IL-6R axis and the schizophrenia.
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