Journal
MOLECULAR & CELLULAR TOXICOLOGY
Volume -, Issue -, Pages -Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
DOI: 10.1007/s13273-023-00353-2
Keywords
Low-dose-rate radiation; TiO(2)NPs; Lung injury; Mice
Categories
Ask authors/readers for more resources
The study investigates the synergistic effects of radiation damage and environmental pollution on cells or tissues. By exposing mice to low-dose-rate radiation and titanium dioxide nanoparticles (TiO2NPs), it was found that the combination of the two stimuli significantly increased pulmonary inflammation through MAPK phosphorylation. This highlights the need to consider the potential combined effects of low-dose radiation and TiO2NPs in patients with respiratory problems.
BackgroundRadiation damage and the cellular response has been studied in various direction, however, the synergic effects of radiation damage with environmental pollution on cells or tissues remained poorly understood. In particular, gene and pathway regulation by low-dose radiation exposure remains unclear. Dust and air pollution in Asian countries contains metal oxide and titanium dioxide nanoparticles (TiO(2)NPs), which exacerbate respiratory distress.ObjectiveTo explore the synergic injury of radiation damage with air pollution, we examined the effects of low-dose-rate radiation with TiO2NPs on pulmonary response in mice.ResultsThirty-six mice (C57bl/6) were divided into six groups: sham, 0.1 Gy, 0.3 Gy, TiO(2)NPs, TiO(2)NPs + 0.1 Gy, and TiO(2)NPs + 0.3 Gy group. Mice were irradiated at a low-dose-rate at a dose of 0.1 Gy (0.182 mGy/h) and 0.3 Gy (0.554 mGy/h) for 24 days and exposed to TiO(2)NPs by intranasal injection at a dose of 0.1 mg daily for 4 days (from day 21 to 24). The combination of low-dose-rate radiation and TiO(2)NPs caused significantly more pulmonary inflammation via MAPK phosphorylation in mice than did each stimulus alone.ConclusionWe conclude that while exposure to each of these two distinct stimuli alone does not cause notable lung damage, they may potentially cause lung damage when combined owing to their synergistic effects. Therefore, we should pay attention to the possible combined effects of low-dose radiation and exposure to TiO(2)NPs, considering their potential danger in patients with respiratory problems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available