A Short Review of Antimalarial Compounds with Sulfonamide Moiety

Malaria is a public health problem that causes thousands of deaths, primarily in children in African regions. Artemisinin-based combination therapies (ACTs) have helped to save thousands of lives; however, due to Plasmodium's resistance to available treatments, there is a need to search for new low-cost drugs that act through different mechanisms of action to contain this disease. This review shows that compounds with sulfonamide moiety, possibly, act as inhibitors of P. falciparum carbonic anhydrases, moreover, when linked to a variety of heterocycles potentiate the activities of these compounds and may be used in the design of new antimalarial drugs.

Automated summary

This review suggests that compounds with sulfonamide moiety may serve as inhibitors of P. falciparum carbonic anhydrases, and when linked to other compounds, they could potentiate the activities and be used in the design of new antimalarial drugs.