Composite material immobilized in 3D-printed support, an economical approach for electrochemical sensing of nimesulide

This work aimed to build a disposable electrode, cheap, and robust, with a maximum manufacturing value of US$ 0.02 per sensor, whose basic structure is a composite material (CM) immobilized on 3D support of acrylonitrile butadiene styrene (ABS), to the determination of Nimesulide (NIM) in different samples. The surface characterization of the electrodes was made by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The electrochemical response for NIM obtained was compared with a commercial Glassy Carbon electrode (GCE), where a 70 % increase in the analytical response was observed. The sensor was applied for the quantification of NIM by the square wave voltammetry (SWV) method in pharmaceutical formulations, tap water, synthetic urine, and breast milk. The optimized method presented a satisfactory linear range of 10 to 50 & mu;mol/L, with a simple sample treatment, good precision (RSD < 3.38 %), and excellent detectability (limit of detection 0.018 & mu;mol/L). Samples were spiked at three concentration levels to evaluate the accuracy of the method, obtaining recovery values from 96.2 to 112.8 %. Thus, the disposable proposed device proves to be a promising analytical tool for routine analysis of NIM in different samples with a minimum sample preparation step (simple dilution).

Automated summary

This study aimed to develop a disposable electrode for the determination of Nimesulide in various samples. The electrode was made of a cheap and robust composite material immobilized on a 3D support. The optimized method showed satisfactory linear range, good precision, and excellent detectability, making the proposed device a promising analytical tool for routine analysis of Nimesulide.