A systematic review on impact of SARS-CoV-2 infection

Innumerable pathogens including RNA viruses have catastrophic pandemic propensity, in turn, SARS-CoV-2 infection is highly contagious. Emergence of SARS-CoV-2 variants with high mutation rate additionally codifies infectious ability of virus and arisen clinical imputations to human health. Although, our knowledge of mechanism of virus infection and its impact on host system has been substantially demystified, uncertainties about the emergence of virus are still not fully understood. To date, there are no potentially curative drugs are identified against the viral infection. Even though, drugs are repurposed in the initial period of infection, many are significantly negative in clinical trials. Moreover, the infection is dependent on organ status, co-morbid conditions, variant of virus and geographic region. This review article aims to comprehensively describe the SARS-CoV-2 infection and the impacts in the host cellular system. This review also briefly provides an overview of genome, proteome and metabolome associated risk to infection and the advancement of therapeutics in SARSCoV-2 infection management.

Automated summary

Numerous pathogens, including RNA viruses, have a potential for catastrophic pandemics, and SARS-CoV-2 infection is highly contagious. The emergence of SARS-CoV-2 variants with high mutation rates further enhances the virus's infectious ability and poses clinical implications for human health. Despite our substantial understanding of the mechanism of virus infection and its impact on the host system, there are still uncertainties about the emergence of the virus. To date, no potentially curative drugs have been identified for viral infection, and repurposed drugs have shown limited efficacy in clinical trials.