4.7 Article

Production of bioactive β-carotene by the endophytic bacterium Citricoccus parietis AUCs with multiple in vitro biological potentials

Journal

MICROBIAL CELL FACTORIES
Volume 22, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12934-023-02108-z

Keywords

Citricoccus parietis; Carotenoids; Pigment; Antibacterial; Antioxidant; Antidiabetic

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This study is the first to extract ss-carotene from endophytic bacteria, which exhibits remarkable antibacterial, antioxidant, and antidiabetic activities, making it a potential source for biomedical therapies.
BackgroundAlthough microalgae and plants are traditionally used for obtaining natural pigments, overexploitation and overharvesting threaten them. Bacteria represent a superior alternative for the production of pigments due to their ability to produce greater amounts in a short time without seasonal restrictions; furthermore, bacterial pigments have a wide range of uses and are safe and biodegradable. This study is the first on the production of ss-carotene as a promising bioactive agent from endophytic bacteria.ResultsThe yellow pigment produced by the endophytic bacterium Citricoccus parietis AUCs (NCBI accession number: OQ448507.1) was extracted by methanol and then purified and identified. One band was obtained by TLC analysis, which was identified as ss-carotene based on its spectroscopic and chromatographic characteristics. The pigment exhibited remarkable antibacterial, antioxidant and antidiabetic activities.ConclusionsThis research may serve as a valuable starting point for exploiting C. parietis AUCs as a potent source of ss-carotene for biomedical therapies. To validate the findings of this research, in vivo studies must be performed.

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