Journal
METABOLIC BRAIN DISEASE
Volume 38, Issue 6, Pages 1769-1800Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-023-01225-3
Keywords
Type 2 diabetes mellitus (T2DM); Alzheimer's disease (AD); Anti-diabetic drugs; Amyloid-beta protein; Tau protein; Insulin resistance
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Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share common pathophysiological mechanisms. The use of anti-diabetic drugs in AD treatment has gained attention due to the interaction between the insulin pathway and AD-related proteins. Multiple studies have shown potential neuroprotective effects of various anti-diabetic drugs in AD treatment, but further research is needed to confirm these effects.
Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an overlap in the pathophysiological mechanisms of these two diseases. Studies have demonstrated insulin pathway alternation may interact with amyloid-beta protein deposition and tau protein phosphorylation, two essential factors in AD. So attention to the use of anti-diabetic drugs in AD treatment has increased in recent years. In vitro, in vivo, and clinical studies have evaluated possible neuroprotective effects of anti-diabetic different medicines in AD, with some promising results. Here we review the evidence on the therapeutic potential of insulin, metformin, Glucagon-like peptide-1 receptor agonist (GLP1R), thiazolidinediones (TZDs), Dipeptidyl Peptidase IV (DPP IV) Inhibitors, Sulfonylureas, Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors, Alpha-glucosidase inhibitors, and Amylin analog against AD. Given that many questions remain unanswered, further studies are required to confirm the positive effects of anti-diabetic drugs in AD treatment. So to date, no particular anti-diabetic drugs can be recommended to treat AD.
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