Amphotericin B, itraconazole, posaconazole, and isavuconazole MICs against clinical Mucorales isolates obtained by visual inspection and spectrophotometric reading according to the EUCAST 9.4 procedure

Article Dermatology

Results from a national survey on COVID-19-associated mucormycosis in Germany: 13 patients from six tertiary hospitals

Danila Seidel et al.

Summary: COVID-19-associated mucormycosis is rare in Germany, mostly reported in patients with comorbidities and impaired immune system who have severe COVID-19 and are treated in the ICU, with a high mortality rate. Compared to mainly rhino-orbito-cerebral CAM in patients with mild COVID-19 in India, the risk for CAM is higher in hospitalized COVID-19 patients.

MYCOSES (2022)

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Review Infectious Diseases

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Martin Hoenigl et al.

Summary: Reports of COVID-19-associated mucormycosis, particularly among patients with uncontrolled diabetes, have been increasing since early 2021. Most patients with COVID-19-associated mucormycosis have uncontrolled diabetes and receive systemic corticosteroid treatment, and rhino-orbital cerebral mucormycosis is the most common disease. COVID-19-associated mucormycosis is associated with high mortality and a significant proportion of survivors experience life-changing morbidities.

LANCET MICROBE (2022)

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Article Microbiology

Azole and Amphotericin B MIC Values against Aspergillus fumigatus: High Agreement between Spectrophotometric and Visual Readings Using the EUCAST EDef 9.3.2 Procedure

Julia Serrano-Lobo et al.

Summary: This study aimed to compare visual and spectrophotometric MIC readings of azoles and amphotericin B against Aspergillus fumigatus sensu lato isolates. High essential and categorical agreements were found between the two methods, indicating that spectrophotometric determination may be a convenient alternative to visual endpoint readings.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Infectious Diseases

Spectrophotometric azole and amphotericin B MIC readings against Aspergillus fumigatus sensu lato using the EUCAST 9.3.2 methodology. Are ≥90 and ≥95% fungal growth inhibition endpoints equally suitable?

Julia Serrano-Lobo et al.

Summary: Spectrophotometric MIC readings obtained using either >= 90% or >= 95% fungal growth inhibition endpoints and following the EUCAST methodology are suitable against Aspergillus fumigatus sensu stricto. However, the >= 95% fungal growth inhibition endpoint is preferred against cryptic species.

MEDICAL MYCOLOGY (2021)

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Article Dermatology

Frequency of occurrence, seasonal variation and antifungal susceptibility of opportunistic Mucorales isolated from hospital soils in Iran

Afsane Vaezi et al.

Summary: This study investigated the frequency, seasonal variation, and antifungal susceptibility of pathogenic Mucorales in soil collected from seven hospitals in Urmia, Iran. The most common species found was Rhizopus arrhizus var. arrhizus, and the highest frequency of Mucorales in soil was detected in wet autumn. In vitro antifungal susceptibility testing showed amphotericin B and posaconazole to be effective against the tested Mucorales isolates.

MYCOSES (2021)

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Article Microbiology