Curcumin Improves Diabetic Cardiomyopathy by Inhibiting Pyroptosis through AKT/Nrf2/ARE Pathway

Article Biochemistry & Molecular Biology

Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice

Zhen Guo et al.

Summary: NEU1 inhibition can improve fibrosis, inflammation, apoptosis, and oxidative stress in diabetic myocardial tissue by activating the AMPK alpha and SIRT3 signaling pathways.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Plant Sciences

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Chen Fu et al.

Summary: This study aims to investigate the effect of Rehmannioside A on cognitive impairment after ischemia in rats and SH-SY5Y cells, and further evaluate the anti-oxidative and anti-ferroptosis mechanisms.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Cell Biology

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO-1 Signal Axis

Yun Wang et al.

Summary: The study demonstrates that irisin postconditioning protects against lung ischemia/reperfusion (I/R) damage by inhibiting ferroptosis through the activation of the Nrf2/HO-1 signaling axis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Pharmacology & Pharmacy

Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway

Keda Yang et al.

Summary: The study found that metformin can promote osteogenic differentiation and alleviate H2O2-induced oxidative damage in osteoblasts through the PI3K/AKT/Nrf2/HO-1 pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

Jincheng Wang et al.

Summary: This article discusses the progress made in understanding the complex interpretation of the cause of IPF, emphasizing the importance of the PI3K/AKT signaling pathway in IPF development, and explores the potential benefits of PI3K/AKT inhibitors in IPF treatment.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Biochemistry & Molecular Biology

Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a

Jozaa Z. ALTamimi et al.

Summary: Curcumin can prevent kidney damage in diabetic rats through a variety of mechanisms, including improvement of renal tubules and mitochondria, reduction of inflammatory cytokines levels, enhancement of mitochondrial function markers, suppression of oxidative stress and apoptosis, among others.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Immunology

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

Maximilian Franke et al.

Summary: The study demonstrates that induction of NLRP3 inflammasome in neurons plays a crucial role in neuroinflammation during acute ischemic stroke. Early blockade of NLRP3 can protect against I/R injury by reducing inflammation and stabilizing the blood-brain barrier.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Environmental Sciences

Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway

Siwen Li et al.

Summary: The study demonstrates that curcumin can protect the liver from mercuric chloride-induced damage through various mechanisms, including reducing levels of liver enzymes, suppressing inflammatory damage and oxidative burst, promoting antioxidant pathway activity, and modulating CYP450 signaling. Additionally, curcumin enhances Nrf2-mediated HO-1 expression in liver cells, providing protection against cell death induced by HgCl2.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Environmental Sciences

Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen*

Guifang Zhao et al.

Summary: This study investigated the protective mechanisms of curcumin in spleen damage induced by mercury, revealing that curcumin combats autophagic cell death induced by mercury by activating the Nrf2 signaling pathway and inhibiting the PI3K-AKT signaling pathway. This research provides insight into potential pharmacological interventions to prevent spleen injury induced by mercury.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Review Cardiac & Cardiovascular Systems

NRF2 in Cardiovascular Diseases: a Ray of Hope!

Ruju Vashi et al.

Summary: Heart failure is a global pandemic affecting millions worldwide. Imbalanced redox homeostasis in cardiac cells leads to various cardiovascular diseases, with NRF2 potentially serving as a target for treatment. NRF2 activators may attenuate hemodynamic stress and have therapeutic effects in cardiovascular diseases.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction

Ji-Young Kang et al.

Summary: By functionalizing extracellular vesicles (EVs) with a cardiac-targeting peptide (CTP) and loading curcumin and miR144-3p simultaneously, enhanced targeting ability, bioavailability, and cardioprotective effects of therapeutic molecules can be achieved, providing a promising nanomedicine strategy for MI therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Plant Sciences

Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway

Weiwei Tao et al.

Summary: The study revealed that magnolol treatment significantly alleviated depressive-like behaviors, suppressed pro-inflammatory cytokines, promoted anti-inflammatory cytokines, and increased the levels of M2 microglia-specific markers. Additionally, magnolol also modulated microglia polarization through the Nrf2/HO-1/NLRP3 signaling pathway.

PHYTOMEDICINE (2021)

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Article Endocrinology & Metabolism

Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats

Chengfeng Miao et al.

Summary: Curcumin and its analog A13 were found to inhibit the NF-kappa B p65 pathway, increase superoxide dismutase activity, decrease malondialdehyde levels, and significantly improve brain histological lesions in diabetic rats. This suggests that A13 may be a potential therapeutic agent for diabetic encephalopathy by regulating inflammation and oxidative stress pathways.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

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Article Pharmacology & Pharmacy

Targeting Nrf2-Mediated Oxidative Stress Response Signaling Pathways as New Therapeutic Strategy for Pituitary Adenomas

Xianquan Zhan et al.

Summary: Oxidative stress and oxidative damage are common pathophysiological characteristics in pituitary adenomas, with Nrf2 playing a central role in the oxidative stress response. Targeting Nrf2 signaling pathways may present a new therapeutic strategy for pituitary adenomas.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p

Chunping Zhu et al.

Summary: The study revealed that GAS5 is upregulated in diabetic cardiomyopathy and promotes DCM progression by regulating miR-26a/b-5p. Knockdown of GAS5 can alleviate myocardial fibrosis and high glucose-induced cardiomyocyte injury. This suggests that GAS5 may be a potential therapeutic target for DCM.

ACTA DIABETOLOGICA (2021)

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Article Medicine, General & Internal

Streptozotocin-induced type 1 and 2 diabetes in rodents: a model for studying diabetic cardiac autonomic neuropathy

Olawale Mathias Akinlade et al.

Summary: This study utilized two different approaches to induce DCAN in T1DM and T2DM models, both of which successfully induced diabetes and exhibited DCAN features. The combination of high dose STZ and HFD with multiple low doses of STZ is recommended for studying DCAN in T1DM and T2DM rat models, respectively.

AFRICAN HEALTH SCIENCES (2021)

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Article Immunology

Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-κB/NLRP3 and PGC1a/SIRT3 pathways

Jianping Yao et al.

Summary: The combination therapy of syringin and tilianin effectively improved cardiac function and DCM markers in diabetic rats, reducing inflammation and oxidative stress while inhibiting apoptosis and maintaining mitochondrial function. These effects were mediated through the TLR4/NF-kappa B/NLRP3 and PGC1 alpha/SIRT3 pathways.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization

Zuzana Tothova et al.

Summary: Erythropoietin (EPO) plays a crucial role in cell survival through triggering signaling cascades such as JAK2/STAT5, MAPK, and PI3K/AKT. This article describes the role of MAPK and PI3K/AKT pathways in red blood cell formation and non-hematopoietic tissues, highlighting the differences between erythroid and non-erythroid cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Diabetes Mellitus and Heart Failure

Filippos Triposkiadis et al.

Summary: Diabetes mellitus is a major risk factor for new-onset heart failure, and vice versa. The pathogenesis of heart failure in diabetes is complex, involving toxic cardiovascular effects of hyperglycemia and metabolic abnormalities. The development of new-onset diabetes in heart failure patients, known as cardiogenic diabetes, is common and often related to insulin resistance.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress

Jose Angel Alonso-Pineiro et al.

Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD

Jingda Li et al.

Summary: Hesperetin, a citrus flavonoid, demonstrates anti-inflammatory effects in NAFLD by activating the PI3 K/AKT-Nrf2 pathway to alleviate oxidative stress, suppress NF-kappa B activation, and reduce inflammatory cytokine secretion. These findings suggest that hesperetin may be an effective dietary supplement for improving NAFLD by targeting both oxidative stress and inflammation pathways.

FOOD & FUNCTION (2021)

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Review Neurosciences