4.7 Article

Engineered inhalable nanocatalytic therapeutics for Parkinson's disease by inducing mitochondrial autophagy

Related references

Note: Only part of the references are listed.
Review Neurosciences

Mitophagy and reactive oxygen species interplay in Parkinson's disease

Bin Xiao et al.

Summary: Mitophagy impairment and oxidative stress play important roles in Parkinson's disease, but their exact interplay is still unclear. Understanding the complex signaling pathways between ROS and mitophagy and identifying suitable therapeutic compounds may contribute to the treatment and prevention of PD.

NPJ PARKINSONS DISEASE (2022)

Review Cell Biology

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

Ren-Qi Yao et al.

Summary: The structural integrity and functional stability of organelles are crucial for cell viability and responsiveness. Dysfunction of multiple organelles is involved in the pathogenesis and progression of various diseases. Organelle-specific autophagy plays a beneficial role in inflammatory disorders by eliminating damaged organelles and maintaining homeostasis.

AUTOPHAGY (2021)

Article Nanoscience & Nanotechnology

Nanoparticles of chosen noble metals as reactive oxygen species scavengers

Polina Ivanova et al.

Summary: Reactive oxygen species (ROS) are important in physiological processes but can pose a threat to health with increased concentrations. Different defense systems in plants, invertebrates, and vertebrates including humans combat ROS, but environmental conditions and lifestyle can interfere with enzyme activity. Therefore, finding alternative ROS scavengers is crucial, with nanozymes being a proposed solution to mimic essential enzyme activities and prevent excessive ROS activity.

NANOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Qinjie Weng et al.

Summary: Catalytic activity tunable ceria nanoparticles have been reported as potential agents for preventing chemotherapy-induced acute kidney injury without compromising the efficacy of chemotherapeutic agents. This context-dependent reactive oxygen species scavenger shows promise for clinical application in cancer patients.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: Implications in Parkinson?s disease

Xiaojuan Han et al.

Summary: The study demonstrates that kaempferol prevents dopaminergic neuronal degeneration in Parkinson's disease by inhibiting lipid peroxidation-mediated mitochondrial damage through promoting lipophagy, providing a potential novel therapeutic strategy for Parkinson's disease and related neurodegenerative diseases.

REDOX BIOLOGY (2021)

Article Neurosciences

Motor Neurons Pathology After Chronic Exposure to MPTP in Mice

Giorgio Vivacqua et al.

NEUROTOXICITY RESEARCH (2020)

Article Chemistry, Multidisciplinary

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease

Jingyi Liu et al.

ACS NANO (2020)

Article Biochemistry & Molecular Biology

Betanin Attenuates Oxidative Stress Induced by 6-OHDA in PC12 Cells via SAPK/JNK and PI3 K Pathways

Elham Hadipour et al.

NEUROCHEMICAL RESEARCH (2020)

Review Geriatrics & Gerontology

Mitochondrial Homeostasis and Signaling in Parkinson's Disease

Antonella Scorziello et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Article Cell Biology

Dependence of PINK1 accumulation on mitochondrial redox system

Feng Gao et al.

AGING CELL (2020)

Article Biochemistry & Molecular Biology

Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity

Ariana Bujan et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2020)

Article Cell Biology

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Atsushi Aoyagi et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Nanoscience & Nanotechnology

Construction of Uniform Cobalt-Based Nanoshells and Its Potential for Improving Li-Ion Battery Performance

Jun-Yu Piao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Medicine, Research & Experimental

Mechanism of intranasal drug delivery directly to the brain

Tyler P. Crowe et al.

LIFE SCIENCES (2018)

Article Multidisciplinary Sciences

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter et al.

NATURE (2018)

Article Chemistry, Multidisciplinary

Sacrificial Cobalt-Carbon Bond Homolysis in Coenzyme B12 as a Cofactor Conservation Strategy

Gregory C. Campanello et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Biochemistry & Molecular Biology

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

Giuseppe Tardiolo et al.

MOLECULES (2018)

Article Biochemistry & Molecular Biology

Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders

Swati Agarwal et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Nursing

N-Acetylcysteine Use in Non-Acetaminophen-Induced Acute Liver Failure

Chelsey M. McPheeters et al.

ADVANCED EMERGENCY NURSING JOURNAL (2016)

Article Biochemistry & Molecular Biology

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

Rui Huang et al.

MOLECULAR CELL (2015)

Review Neurosciences

Regulation of mitophagy in ischemic brain injury

Yang Yuan et al.

NEUROSCIENCE BULLETIN (2015)

Review Cell Biology

Receptor-mediated mitophagy in yeast and mammalian systems

Lei Liu et al.

CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Parkinson's Disease-Associated Dj-1 Mutations Increase Abnormal Phosphorylation of Tau Protein through Akt/Gsk-3β Pathways

Yangang Wang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

Review Biochemistry & Molecular Biology

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

Tohru Fukai et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Review Neurosciences

The 6-hydroxydopamine model of Parkinson's disease

Nicola Simola et al.

NEUROTOXICITY RESEARCH (2007)

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)