Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells

The skin is the largest organ of the human body, composed of a diverse range of cell types, non-cellular components, and an extracellular matrix. With aging, molecules that are part of the extracellular matrix undergo qualitative and quantitative changes and the effects, such as a loss of skin firmness or wrinkles, can be visible. The changes caused by the aging process do not only affect the surface of the skin, but also extend to skin appendages such as hair follicles. In the present study, the ability of marine-derived saccharides, L-fucose and chondroitin sulphate disaccharide, to support skin and hair health and minimize the effects of intrinsic and extrinsic aging was investigated. The potential of the tested samples to prevent adverse changes in the skin and hair through stimulation of natural processes, cellular proliferation, and production of extracellular matrix components collagen, elastin, or glycosaminoglycans was investigated. The tested compounds, L-fucose and chondroitin sulphate disaccharide, supported skin and hair health, especially in terms of anti-aging effects. The obtained results indicate that both ingredients support and promote the proliferation of dermal fibroblasts and dermal papilla cells, provide cells with a supply of sulphated disaccharide GAG building blocks, increase ECM molecule production (collagen and elastin) by HDFa, and support the growth phase of the hair cycle (anagen).

Automated summary

This study investigated the effects of marine-derived saccharides, L-fucose and chondroitin sulphate disaccharide, on skin and hair health, as well as their impact on intrinsic and extrinsic aging. The results indicate that both ingredients supported and promoted the proliferation of dermal fibroblasts and dermal papilla cells, provided cells with a supply of sulphated disaccharide GAG building blocks, increased ECM molecule production (collagen and elastin) by HDFa, and supported the growth phase of the hair cycle (anagen).