Journal
MACROMOLECULES
Volume 56, Issue 10, Pages 3538-3549Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.3c00256
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Hybrid molecular brushes (HMBs) are polymeric constructs with a linear polymeric backbone and polymeric side chains, while hybrid-block graft copolymers (HCPs) have a backbone consisting of more than one polymer. In this study, we developed a facile method for synthesizing amphiphilic, biodegradable HCPs composed of a hydrophilic block of poly(ethylene glycol) and a hydrophobic block of poly(2-oxazolines) modified by side chains of polycaprolactone. We determined the critical micelle concentration, investigated the uptake and partitioning of beta-carotene in the micelles, and studied the brush architecture of the HCPs.
Hybrid molecular brushes (HMBs), or bottlebrush polymers, are polymeric constructs containing a linear polymeric backbone and polymeric side chains with different chemical characteristics. Hybrid-block graft copolymers (HCPs) are similar to traditional HMBs, except their backbone consists of more than one polymer. We developed a facile method for the synthesis of a family of amphiphilic, biodegradable HCPs composed of two blocks: a hydrophilic block of poly(ethylene glycol) and a hydrophobic block of poly(2-oxazolines) modified by side chains of polycaprolactone. This was achieved by modification of the precursor 2-oxazoline monomers with a thiol-containing compound via a thiol-ene click chemistry reaction, followed by ring-opening polymerization of the monomer initiated by a poly(ethylene glycol) methyl ether tosylate macroinitiator. Lastly, polycaprolactone side chains were grafted via ring-opening polymerization yielding the amphiphilic HCPs. Herein, we determined the critical micelle concentration (cmc), showed the uptake and partitioning of beta-carotene in the micelles, and studied the brush architecture. The chemical structure, molecular weight, and morphology of the functionalized backbone, block copolymers, and HCPs were also determined.
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