Organ dysfunction and failure in liver disease

Article Gastroenterology & Hepatology

Pulmonary impairment independently determines mortality in critically ill patients with acute-on-chronic liver failure

Martin S. Schulz et al.

Summary: In ACLF patients, both pulmonary failure and mechanical ventilation are associated with worse prognosis. The grade of pulmonary impairment should be considered in the risk assessment for ACLF patients.

LIVER INTERNATIONAL (2023)

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Review Gastroenterology & Hepatology

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Gabriel Mezzano et al.

Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.

GUT (2022)

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Article Respiratory System

ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure

Simon Oczkowski et al.

Summary: This article introduces the use of high-flow nasal cannula (HFNC) in patients with acute respiratory failure and provides corresponding clinical recommendations based on evidence. HFNC is a valuable noninvasive respiratory support intervention that can assist clinicians in choosing the most appropriate treatment method.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Gastroenterology & Hepatology

Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial

Vishal C. Patel et al.

Summary: Rifaximin-alpha can alleviate hepatic encephalopathy and reduce the likelihood of infection by reducing systemic inflammation and promoting gut barrier repair.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Discordance in categorization of acute-on-chronic liver failure in the United Network for Organ Sharing database

Brian P. Lee et al.

Summary: In this study, we found that the categorization of ACLF by UNOS showed weak agreement with manual chart review. These findings are informative for ongoing allocation policy discussions, highlight the importance of prospective studies regarding ACLF in liver transplantation, and should encourage UNOS reform.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

The Prediction of In-Hospital Mortality in Decompensated Cirrhosis with Acute-on-Chronic Liver Failure

Florence Wong et al.

Summary: Acute-on-chronic liver failure (ACLF) is a condition in cirrhosis associated with organ failure (OF) and high short-term mortality. The EASL-CLIF and NACSELD ACLF definitions have been shown to predict ACLF prognosis effectively. Both systems provide valuable information for predicting in-hospital mortality in patients with decompensated cirrhosis.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis

Adria Juanola et al.

Summary: This study found that in patients with decompensated cirrhosis, urinary L-FABP levels are independently associated with the 3-month clinical course and can predict mortality and ACLF development.

JOURNAL OF HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Haemostatic alterations and management of haemostasis in patients with cirrhosis

Ton Lisman et al.

Summary: Patients with cirrhosis experience complex changes in their haemostatic system, but it remains balanced overall. New understanding of clinical management for patients with cirrhosis has emerged, although there is a lack of solid evidence from well-designed clinical studies. The paper outlines recent advances in bleeding and thrombotic complications in patients with cirrhosis.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial]

Rakhi Maiwall et al.

Summary: In patients with cirrhosis and sepsis-induced hypotension, 20% albumin leads to faster improvement in hemodynamics and lactate clearance compared to plasmalyte, while the 28-day survival rate is similar.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Terlipressin use and respiratory failure in patients with hepatorenal syndrome type 1 and severe acute-on-chronic liver failure

Florence Wong et al.

Summary: The use of terlipressin in patients with HRS1 and ACLF may increase the incidence of RF, especially in patients with grade 3 ACLF. Patients with hypoxemia are at an increased risk of RF and mortality.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients With Cirrhosis: Expert Review

Steven L. Flamm et al.

Summary: This article reviews the clinical management of patients with cirrhosis and acute kidney injury, providing practical advice based on the best available evidence.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure

Florence Wong et al.

Summary: Bacterial infections can trigger acute-on-chronic liver failure, with varying rates and clinical characteristics in different geographic regions, particularly with the highest incidence in the Indian subcontinent.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis

Cristina Sole et al.

Summary: Patients with cirrhosis exhibit significant alterations in gut microbiome, particularly pronounced in those with ACLF, correlated with disease stages and complications, and predictive of survival. These findings suggest a potential role of gut microbiome in disease progression and prognosis, warranting further validation in future studies.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Response to Terlipressin and Albumin Is Associated With Improved Liver Transplant Outcomes in Patients With Hepatorenal Syndrome

Salvatore Piano et al.

Summary: The response to treatment with terlipressin and albumin in patients with AKI-HRS can reduce the need for renal replacement therapy after liver transplantation (LT) and decrease the risk of chronic kidney disease (CKD) at 1 year post-LT.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality

Dalila Costa et al.

Summary: This study revealed significant differences in liver function, portal hypertension, and systemic inflammation among patients with advanced chronic liver disease at different prognostic stages, with IL-6 levels proving to be predictive of decompensation and mortality risk in decompensated patients.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

Vicente Arroyo et al.

Summary: Systemic inflammation may be a key feature of acute decompensation of cirrhosis, affecting organ system function through various mechanisms and working synergistically with traditional pathways to contribute to the development of AD. It can exacerbate splanchnic vasodilation by overactivating the endogenous vasoconstrictor systems, leading to hypoperfusion in certain vascular beds such as the renal circulation. Additionally, systemic inflammation may cause immune-mediated tissue damage and induce significant metabolic changes.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome

F. Wong et al.

Summary: The study confirmed the efficacy of terlipressin plus albumin in treating type 1 hepatorenal syndrome, but also identified serious adverse events such as respiratory failure.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Medicine, General & Internal

Acute-on-Chronic Liver Failure in Cirrhosis

Carmine Gambino et al.

Summary: ACLF is a syndrome that develops in patients with acutely decompensated chronic liver disease, characterized by high mortality, organ failures, and systemic inflammation. Different scientific societies have proposed diagnostic criteria and clinical characteristics for ACLF, along with established and experimental treatments. Further research is needed to better understand the pathophysiology of the syndrome and explore new therapies.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: Results of the ELITA/EF-CLIF collaborative study (ECLIS)

Luca S. Belli et al.

Summary: This study reveals significant variations in the listing of patients with ACLF in Europe despite favorable post-LT survival. Risk factors for post-LT mortality were identified, enabling a more precise prognostic assessment of patients with ACLF.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Jonel Trebicka et al.

Summary: This study analyzed the precipitants leading to acute decompensation in cirrhosis patients, identifying proven bacterial infections and severe alcoholic hepatitis as the main causes. The number of precipitants was significantly associated with 90-day mortality, emphasizing the need for specific preventive and therapeutic strategies targeting these events.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Management of bacterial and fungal infections in cirrhosis: The MDRO challenge

Javier Fernandez et al.

Summary: Bacterial infections are common in cirrhotic patients with acute decompensation or acute-on-chronic liver failure, while fungal infections are less common but associated with high short-term mortality. Early diagnosis and appropriate empirical treatment are crucial in managing these patients. Combatting antibiotic resistance and adopting more complex treatment strategies are essential in the current management of cirrhotic patients.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on- chronic liver failure: A multicenter randomized trial (GRAFT study)

Cornelius Engelmann et al.

Summary: In this multicenter controlled trial, G-CSF did not show significant beneficial effects on ACLF patients compared to standard medical therapy alone. The study was terminated prematurely due to futility after analysis. Therefore, G-CSF should not be recommended as a standard treatment for ACLF.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Intensive care management of acute-on-chronic liver failure

William Bernal et al.

Summary: Acute-on-chronic liver failure syndrome involves liver function deterioration, extrahepatic organ failure, and high mortality rate, requiring rapid and coherent management in the intensive care unit to improve patient outcomes.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

EASL-CLIF criteria outperform NACSELD criteria for diagnosis and prognostication in ACLF

Feng Li et al.

Summary: This study compared the prevalence and 30-day mortality rates of patients with ACLF identified by the EASL-CLIF and NACSELD criteria, revealing significant discordance between the two. The EASL-CLIF criteria showed better sensitivity in detecting ACLF and had a better prognostic capability.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Joan Claria et al.

Summary: This study focused on blood lipidomics in cirrhosis patients, revealing a generalized suppression of lipids in circulation. Specific lipid fingerprints were identified for distinguishing AD and ACLF, with liver dysfunction and infections playing key roles in their dynamics. Moreover, blood lysophosphatidylcholine levels increased in patients after albumin therapy.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction

Cornelius Engelmann et al.

Summary: Patients with acutely decompensated cirrhosis have a poor prognosis and often progress to acute-on-chronic liver failure. The pathomechanisms involved in decompensation and disease progression are not well understood, highlighting the need for novel therapeutic targets. Research has identified systemic inflammation, mitochondrial dysfunction, oxidative stress, and metabolic changes as key factors leading to tissue injury and extrahepatic organ failure, emphasizing the urgent need for new treatment strategies to improve patient outcomes.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Biomarkers of extracellular matrix formation are associated with acute-on-chronic liver failure

Annarein J. C. Kerbert et al.

Summary: This study provides evidence of severe net interstitial collagen deposition in ACLF for the first time and identifies the association between PRO-C6 and (extrahepatic) organ failures and mortality. Further studies are needed to define the pathogenic significance of these observations.

JHEP REPORTS (2021)

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Review Gastroenterology & Hepatology

Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment

Giacomo Zaccherini et al.

Summary: ACLF is a life-threatening condition characterized by sudden worsening of clinical outcomes in patients with cirrhosis or chronic liver disease. Different definitions, diagnostic criteria, and treatments have been proposed, with supportive therapy and liver transplantation showing efficacy in managing ACLF. Future studies on mechanistic treatments to improve patient survival are needed.

JHEP REPORTS (2021)

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Article Gastroenterology & Hepatology

Terlipressin Is Superior to Noradrenaline in the Management of Acute Kidney Injury in Acute on Chronic Liver Failure

Vinod Arora et al.

HEPATOLOGY (2020)

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Review Medicine, General & Internal

Role of endotoxemia in causing renal dysfunction in cirrhosis

Jennifer L. Peng et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2020)

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Article Gastroenterology & Hepatology

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Richard Moreau et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Model for End-Stage Liver Disease-Lactate and Prediction of Inpatient Mortality in Patients With Chronic Liver Disease

Naveed Sarmast et al.

HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Cristina Lopez-Vicario et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Cardiodynamic state is associated with systemic inflammation and fatal acute-on-chronic liver failure

Michael Praktiknjo et al.

LIVER INTERNATIONAL (2020)

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Review Medicine, General & Internal

Acute-on-Chronic Liver Failure

Vicente Arroyo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: liver transplant provides survival benefit in patients with acute on chronic liver failure

Mohamed A. Abdallah et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

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Article Gastroenterology & Hepatology

The Use of NACSELD and EASL-CLIF Classification Systems of ACLF in the Prediction of Prognosis in Hospitalized Patients With Cirrhosis

Zhujun Cao et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

Christopher F. Rose et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Critical Care Medicine

Liver-lung interactions in acute respiratory distress syndrome

Raquel Herrero et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

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Article Gastroenterology & Hepatology

Prognostic Role of Ammonia in Patients With Cirrhosis

Shalimar et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Patients With Acute on Chronic Liver Failure Grade 3 Have Greater 14-Day Waitlist Mortality Than Status-1a Patients

Vinay Sundaram et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Lactate and number of organ failures predict intensive care unit mortality in patients with acute-on-chronic liver failure

Filipe S. Cardoso et al.

LIVER INTERNATIONAL (2019)

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Editorial Material Gastroenterology & Hepatology

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update

Shiv Kumar Sarin et al.

HEPATOLOGY INTERNATIONAL (2019)

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Article Gastroenterology & Hepatology

Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation

Vinay Sundaram et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival

Cristina Sole et al.

LIVER INTERNATIONAL (2019)

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Article Respiratory System

Guidelines on the management of acute respiratory distress syndrome

Mark J. D. Griffiths et al.

BMJ OPEN RESPIRATORY RESEARCH (2019)

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Article Gastroenterology & Hepatology

Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Tianzhou Wu et al.

GUT (2018)

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Article Gastroenterology & Hepatology

Association Between Grade of Acute on Chronic Liver Failure and Response to Terlipressin and Albumin in Patients With Hepatorenal Syndrome

Salvatore Piano et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Article Critical Care Medicine

Pathophysiology of Septic Shock

James A. Russell et al.

CRITICAL CARE CLINICS (2018)

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Article Gastroenterology & Hepatology

NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis

Jacqueline G. O'Leary et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis

Qun-Qun Jiang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Medicine, General & Internal

Hepatorenal syndrome

Pere Gines et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Review Critical Care Medicine

Acute Respiratory Failure and Pulmonary Complications in End-Stage Liver Disease

Nida Qadir et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Respiratory System

Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure

Bram Rochwerg et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Article Gastroenterology & Hepatology

Acute-on-chronic liver failure: an update

Ruben Hernaez et al.

GUT (2017)

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Article Gastroenterology & Hepatology

Fecal Microbiota Transplant From a Rational Stool Donor Improves Hepatic Encephalopathy: A Randomized Clinical Trial

Jasmohan S. Bajaj et al.

HEPATOLOGY (2017)

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Editorial Material Gastroenterology & Hepatology

New diagnostic criteria and management of Acute Kidney Injury

Florence Wong et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Incidence, predictors and outcomes of acute-on-chronic liver failure in outpatients with cirrhosis

Salvatore Piano et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3

Florent Artru et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Impact of acute-on-chronic liver failure on 90-day mortality following a first liver transplantation

Eric Levesque et al.

LIVER INTERNATIONAL (2017)

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Article Critical Care Medicine

An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome

Eddy Fan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1

F. J. Gifford et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2017)

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Review Gastroenterology & Hepatology

Comparative efficacy of pharmacological strategies for management of type 1 hepatorenal syndrome: a systematic review and network meta-analysis

Antonio Facciorusso et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Surgery

Simultaneous Liver-Kidney Allocation Policy: A Proposal to Optimize Appropriate Utilization of Scarce Resources

R. N. Formica et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

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Article Gastroenterology & Hepatology

Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients With Cirrhosis and Hepatorenal Syndrome Type 1

Thomas D. Boyer et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Systemic Inflammation in Decompensated Cirrhosis: Characterization and Role in Acute-on-Chronic Liver Failure

Joan Claria et al.

HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis

X. Ariza et al.

JOURNAL OF HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF)

Henning Gronbaek et al.

JOURNAL OF HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites

Paolo Angeli et al.

GUT (2015)

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Article Gastroenterology & Hepatology

Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis

Thierry Gustot et al.

HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults

Yu Shi et al.

HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

AKI in patients with acute on chronic liver failure is different from acute decompensation of cirrhosis

Rakhi Maiwall et al.

HEPATOLOGY INTERNATIONAL (2015)

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Article Critical Care Medicine

Role of renal replacement therapy in patients with type 1 hepatorenal syndrome receiving combination treatment of vasoconstrictor plus albumin

Zhiwei Zhang et al.

JOURNAL OF CRITICAL CARE (2015)

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Review Gastroenterology & Hepatology

Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure

Manuel Romero-Gomez et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

Outcomes of Patients With Cirrhosis and Hepatorenal Syndrome Type 1 Treated With Liver Transplantation

Florence Wong et al.

LIVER TRANSPLANTATION (2015)

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Article Gastroenterology & Hepatology

Acute kidney injury and acute-on-chronic liver failure classifications in prognosis assessment of patients with acute decompensation of cirrhosis

Paolo Angeli et al.

GUT (2015)

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Article Gastroenterology & Hepatology

Survival in Infection-Related Acute-on-Chronic Liver Failure Is Defined by Extrahepatic Organ Failures

Jasmohan S. Bajaj et al.

HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)

Juan Cordoba et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Outcome of patients with cirrhosis requiring mechanical ventilation in ICU

Eric Levesque et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

Rajiv Jalan et al.

JOURNAL OF HEPATOLOGY (2014)

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Review Critical Care Medicine

A UNIFIED THEORY OF SEPSIS- INDUCED ACUTE KIDNEY INJURY: INFLAMMATION, MICROCIRCULATORY DYSFUNCTION, BIOENERGETICS, AND THE TUBULAR CELL ADAPTATION TO INJURY

Hernando Gomez et al.

SHOCK (2014)

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Article Gastroenterology & Hepatology

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

Richard Moreau et al.

GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial

Rafael Banares et al.

HEPATOLOGY (2013)

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Article Gastroenterology & Hepatology

Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis

Naina Shah et al.

LIVER INTERNATIONAL (2013)

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Article Medicine, Research & Experimental

Lactate metabolism in chronic liver disease

Johanne B. Jeppesen et al.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2013)

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Article Gastroenterology & Hepatology

Granulocyte-colony stimulating factor therapy improves survival in patients with hepatitis B virus-associated acute-on-chronic liver failure

Xue-Zhang Duan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure

Andreas Kribben et al.

GASTROENTEROLOGY (2012)

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Article Gastroenterology & Hepatology

Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression

Naina Shah et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Hepatorenal syndrome, MELD score and liver transplantation: An evolving issue with relevant implications for clinical practice

Paolo Angeli et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Mechanisms of TNFα-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNFα and endocannabinoids

Ying-Ying Yang et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Bedside Sublingual Video Imaging of Microcirculation in Assessing Bacterial Infection in Cirrhosis

Muhammad Y. Sheikh et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

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Article Gastroenterology & Hepatology

Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome:: A randomized study

Marta Martin-Llahi et al.

GASTROENTEROLOGY (2008)

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Article Gastroenterology & Hepatology

A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome

Arun J. Sanyal et al.

GASTROENTEROLOGY (2008)

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Article Gastroenterology & Hepatology

Adrenal insufficiency in patients with cirrhosis and septic shock:: Effect of treatment with hydrocortisone on survival

Javier Fernandez et al.

HEPATOLOGY (2006)

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Organ dysfunction and failure in liver disease

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