4.7 Article

Long-term outcome of liver transplantation for autoimmune hepatitis: A French nationwide study over 30 years

Journal

LIVER INTERNATIONAL
Volume 43, Issue 5, Pages 1068-1079

Publisher

WILEY
DOI: 10.1111/liv.15552

Keywords

biliary complication; chronic rejection; recurrence; sepsis; survival

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This study evaluated long-term survival and prognostic factors for patients with autoimmune hepatitis (AIH) after liver transplantation (LT), particularly the impact of recurrent AIH (rAIH). The results showed that AIH patients had excellent survival rates after LT, but disease recurrence and chronic rejection reduced graft survival.
Background & AimsAutoimmune hepatitis (AIH) is a rare indication for liver transplantation (LT). The aims of this study were to evaluate long-term survival after LT for AIH and prognostic factors, especially the impact of recurrent AIH (rAIH). MethodsA multicentre retrospective nationwide study including all patients aged >= 16 transplanted for AIH in France was conducted. Early deaths and retransplantations (<= 6 months) were excluded. ResultsThe study population consisted of 301 patients transplanted from 1987 to 2018. Median age at LT was 43 years (IQR, 29.4-53.8). Median follow-up was 87.0 months (IQR, 43.5-168.0). Seventy-four patients (24.6%) developed rAIH. Graft survival was 91%, 79%, 65% at 1, 10 and 20 years respectively. Patient survival was 94%, 84% and 74% at 1, 10 and 20 years respectively. From multivariate Cox regression, factors significantly associated with poorer patient survival were patient age >= 58 years (HR = 2.9; 95% CI, 1.4-6.2; p = 0.005) and occurrence of an infectious episode within the first year after LT (HR = 2.5; 95% CI, 1.2-5.1; p = 0.018). Risk factors for impaired graft survival were: occurrence of rAIH (HR = 2.7; 95% CI, 1.5-5.0; p = 0.001), chronic rejection (HR = 2.9; 95% CI, 1.4-6.1; p = 0.005), biliary (HR = 2.0; 95% CI, 1.2-3.4; p = 0.009), vascular (HR = 1.8; 95% CI, 1.0-3.1; p = 0.044) and early septic (HR = 2.1; 95% CI, 1.2-3.5; p = 0.006) complications. ConclusionOur results confirm that survival after LT for AIH is excellent. Disease recurrence and chronic rejection reduce graft survival. The occurrence of an infectious complication during the first year post-LT identifies at-risk patients for graft loss and death.

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