Mapping antigens of membranous nephropathy: almost there

Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel putative antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.

Automated summary

Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. Recent advances have led to the discovery of 7 novel putative antigens and the identification of target antigens in approximately 90% of MN cases. This study also proposes a working algorithm for evaluating the target antigens in MN, along with the description of 10 other novel putative antigens.