Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-023-04017-6
Keywords
Antigenicity; CAR T cells; DAMPs; Immune checkpoint inhibitors; Pattern recognition receptors; Tumor microenvironment
Categories
Ask authors/readers for more resources
Mammalian cells can undergo regulated cell death in response to specific disruptions of homeostasis, leading to adaptive immune responses. This immunogenic cell death (ICD) is distinct from immunostimulation or inflammatory responses that do not depend on cellular demise. In this article, we critically discuss the key concepts and mechanisms of ICD and its implications for cancer immunotherapy.
Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available