Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/jsfa.12716
Keywords
type 2 diabetes; probiotics; liver injury; hepatic metabolism; metabolomics
Ask authors/readers for more resources
In this study, it was found that treatment with Lactobacillus plantarum SHY130 (LPSHY130) improved liver function and pathological damage in a murine model of type 2 diabetes (T2D). Untargeted metabolome analysis revealed that LPSHY130 treatment regulated changes in 11 metabolites involved in purine metabolism, amino acid metabolism, choline metabolism, and pantothenate and coenzyme A biosynthesis pathways. Furthermore, correlation analysis indicated that intestinal microbiota can adjust hepatic metabolic changes.
BACKGROUNDAmong type 2 diabetes (T2D) patients, the incidence rate of liver metabolic disorders is much higher than that in healthy subjects. It was observed in our previous research that diabetic symptoms were improved by Lactobacillus plantarum SHY130 (LPSHY130) isolated from yak yogurt in a murine model of T2D. This study sought to investigate the LPSHY130-mediated hepatic metabolic regulation in a murine model of T2D. RESULTSTreatment with LPSHY130 improved liver function and pathological damage in diabetic mice. Untargeted metabolome analysis revealed that T2D-induced changes in 11 metabolites were regulated after LPSHY130 treatment, mainly involving purine metabolism, amino acid metabolism, and choline metabolism and pantothenate and coenzyme A biosynthesis pathways. In addition, correlation analysis indicated that hepatic metabolic changes can be adjusted by the intestinal microbiota. CONCLUSIONOverall, this study suggests that treatment with LPSHY130 relieves liver injury and regulates liver metabolism in a murine model of T2D, thus providing a theoretical basis for the use of probiotics as dietary supplements to regulate hepatic metabolic disorders associated with T2D. (c) 2023 Society of Chemical Industry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available