4.5 Article

Effects of Long-Term Storage on the Biobanked Neonatal Dried Blood Spot Metabolome

Related references

Note: Only part of the references are listed.
Article Pediatrics

Gestational age-dependent development of the neonatal metabolome

Madeleine Ernst et al.

Summary: This study utilized metabolomics tools to measure over 9000 metabolites in 298 neonatal blood samples, identifying approximately 16% of metabolites significantly correlated with gestational age. Eighty-three metabolites explained 48% of the variance in gestational age, revealing the age-dependent development of the neonatal blood metabolome.

PEDIATRIC RESEARCH (2021)

Article Biotechnology & Applied Microbiology

Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

Kai Duehrkop et al.

Summary: CANOPUS is a computational tool that uses a deep neural network to predict compound classes from fragmentation spectra, even for compounds lacking reference data. In evaluation, CANOPUS showed high prediction performance and outperformed other baseline methods. It has broad utility in investigating chemical diversity in plants and discovering natural products, providing biological insights at the compound class level.

NATURE BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Studying Autism Using Untargeted Metabolomics in Newborn Screening Samples

Julie Courraud et al.

Summary: The study analyzed the metabolomic profiles of newborns later diagnosed with Autism Spectrum Disorder (ASD). While no clear distinction between cases and controls was revealed, many metabolites previously associated with ASD were found, suggesting that biochemical markers of ASD may exist at birth and can be monitored through newborn screening.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

Article Endocrinology & Metabolism

Assessment of the effects of repeated freeze thawing and extended bench top processing of plasma samples using untargeted metabolomics

Kelli Goodman et al.

Summary: Clinical metabolomics is useful for screening IEM and variant classification in patients with rare diseases. This study found that extended thawing and repeated freeze-thaw cycles can impact the stability of biochemical compounds in plasma samples, with a small percentage affected after multiple cycles.

METABOLOMICS (2021)

Article Multidisciplinary Sciences

Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment

Robin Schmid et al.

Summary: The authors develop a new Ion Identity Molecular Networking (IIMN) approach that integrates chromatographic peak shape correlation analysis to connect and collapse different ion species of the same molecule, improving network connectivity for structurally related molecules.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Dried Blood Spot (DBS) Methodology Study for Biomarker Discovery in Lysosomal Storage Disease (LSD)

Corina-Marcela Rus et al.

Summary: This study aims to increase the efficiency of methods for biomarker development in the context of rare diseases through two independent experiments integrated into the screening of the human blood metabolome, leading to an improved impact on the reliability of detected compounds.

METABOLITES (2021)

Article Genetics & Heredity

Neonatal Screening in Europe Revisited: An ISNS Perspective on the Current State and Developments Since 2010

J. Gerard Loeber et al.

Summary: Neonatal screening in Europe has been evolving since the 1960s, with significant progress made between 2010 and 2020 in terms of methodological advancements and expansion of screened conditions. Collaboration within Europe is increasing, which is crucial for timely detection and intervention for newborns with rare diseases.

INTERNATIONAL JOURNAL OF NEONATAL SCREENING (2021)

Article Chemistry, Analytical

spectrum_utils: A Python Package for Mass Spectrometry Data Processing and Visualization

Wout Bittremieux

ANALYTICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Improved Dried Blood Spot-Based Metabolomics: A Targeted, Broad-Spectrum, Single-Injection Method

Kefeng Li et al.

METABOLITES (2020)

Article Biochemical Research Methods

Feature-based molecular networking in the GNPS analysis environment

Louis-Felix Nothias et al.

NATURE METHODS (2020)

Article Biochemical Research Methods

SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information

Kai Duhrkop et al.

NATURE METHODS (2019)

Article Microbiology

A Novel Sparse Compositional Technique Reveals Microbial Perturbations

Cameron Martino et al.

MSYSTEMS (2019)

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Effects of Long-Term Storage at -80 °C on the Human Plasma Metabolome

Antje Wagner-Golbs et al.

METABOLITES (2019)

Article Biochemistry & Molecular Biology

MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools

Madeleine Ernst et al.

METABOLITES (2019)

Article Biochemical Research Methods

Long-Term Stability of Human Plasma Metabolites during Storage at-80 °C

Mark Haid et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Article Biochemical Research Methods

Propagating annotations of molecular networks using in silico fragmentation

Ricardo R. da Silva et al.

PLOS COMPUTATIONAL BIOLOGY (2018)

Article Biochemical Research Methods

Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry

Joe Wandy et al.

BIOINFORMATICS (2018)

Article Biochemical Research Methods

mixOmics: An R package for 'omics feature selection and multiple data integration

Florian Rohart et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

Article Biotechnology & Applied Microbiology

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Mingxun Wang et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Topic modeling for untargeted substructure exploration in metabolomics

Justin Johan Jozias van der Hooft et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Chemistry, Multidisciplinary

ClassyFire: automated chemical classification with a comprehensive, computable taxonomy

Yannick Djoumbou Feunang et al.

JOURNAL OF CHEMINFORMATICS (2016)

Review Pharmacology & Pharmacy

Therapeutic Drug Monitoring by Dried Blood Spot: Progress to Date and Future Directions

Abraham J. Wilhelm et al.

CLINICAL PHARMACOKINETICS (2014)

Article Biochemical Research Methods

Stability of metabolites in dried blood spots stored at different temperatures over a 2-year period

Philippa Prentice et al.

BIOANALYSIS (2013)

Editorial Material Public, Environmental & Occupational Health

Introduction to Danish (nationwide) registers on health and social issues: Structure, access, legislation, and archiving

Lau Caspar Thygesen et al.

SCANDINAVIAN JOURNAL OF PUBLIC HEALTH (2011)

Article Biochemical Research Methods

ProteoWizard: open source software for rapid proteomics tools development

Darren Kessner et al.

BIOINFORMATICS (2008)

Article Endocrinology & Metabolism

Proposed minimum reporting standards for chemical analysis

Lloyd W. Sumner et al.

METABOLOMICS (2007)

Article Endocrinology & Metabolism

Storage policies and use of the Danish Newborn Screening Biobank

B. Norgaard-Pedersen et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2007)

Article Medical Laboratory Technology

Long-term stability of amino acids and acylcarnitines in dried blood spots

Kristina Anna Strnadova et al.

CLINICAL CHEMISTRY (2007)

Article Nutrition & Dietetics

Glutathione metabolism and its implications for health

GY Wu et al.

JOURNAL OF NUTRITION (2004)