☆ 4.8 Article

Nickel-Catalyzed Regio- and Enantioselective Borylative Coupling of Terminal Alkenes with Alkyl Halides Enabled by an Anionic Bisoxazoline Ligand

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α-Chloroboronates via Dual Nickel/Photoredox Catalysis

Jun Zhou et al.

Summary: Substantial advances have been made in enantioconvergent C(sp3)-C(sp3) bond formations with the utilization of dual nickel/photoredox catalysis system. This method allows for direct coupling of two different alkyl halides, resulting in the formation of chiral secondary alkyl boronic esters. These intermediates are important in organic synthesis and provide a desirable strategy for the construction of enantioenriched complex molecules.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Asymmetric Double Hydroxycarbonylation of Alkynes to Chiral Succinic Acids Enabled by Palladium Relay Catalysis

Xiaolei Ji et al.

Summary: In this study, a Pd-catalyzed asymmetric double hydroxycarbonylation of terminal alkynes was developed using relay catalysis, which provided an efficient route to chiral succinic acids. This method demonstrated high yields and enantioselectivity for 41 examples and showcased its synthetic utilities in the facile synthesis of key intermediates for chiral pharmaceuticals.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Article Chemistry, Organic

Nickel-Catalyzed Migratory Benzylboration of Allylbenzenes

Yangyang Li et al.

Summary: We report a comparatively under-researched migratory difunctionalization of alkenes, which is a nickel-catalyzed, divergent, solvent-controlled 1,1- or 1,3-regioselective benzylboration of allylbenzenes. This reaction provides efficient access to primary and secondary alkyl boronates with good regioselectivity and wide functional group tolerance.

TETRAHEDRON LETTERS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Practical Synthesis of Chiral Allylboronates by Asymmetric 1,1-Difunctionalization of Terminal Alkenes

Caocao Sun et al.

Summary: We report a modular catalytic method for the enantioselective synthesis of chiral allylboronates from abundant feedstock chemicals. This method shows advantages in terms of the use of inexpensive catalyst, mild reaction conditions, wide substrate scope, scalability, and practicality. The utility of the method is demonstrated by the rapid synthesis of key intermediates of complex drug molecules. Mechanistic studies reveal the regioselective nature of beta-H elimination and the enantio-determining step involving reversible homolysis and convergance to a lower energy pre-reductive elimination intermediate.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Copper-Catalyzed Stereospecific Transformations of Alkylboronic Esters

Ningxin Xu et al.

Summary: Copper-catalyzed stereospecific cross-couplings of boronic esters have been reported. Through a simple transformation, commercially available inexpensive compounds can be converted into synthetically useful compounds.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Remote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes

Wei Zhao et al.

Summary: This study presents an amide-directed, rhodium-catalyzed highly diastereo- and enantioselective hydroboration reaction which provides a facile access to enantioenriched amines containing beta,gamma-vicinal stereocenters. Computational studies indicate that migratory insertion of the alkene into rhodium hydride controls the enantioselectivity.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Ni-Catalyzed Enantioselective Dialkyl Carbinol Synthesis via Decarboxylative Cross-Coupling: Development, Scope, and Applications

Yang Gao et al.

Summary: This article reports the first enantioselective decarboxylative Negishitype alkylations of alpha-oxy carboxylic acids via the intermediacy of redox-active esters (RAEs). The transformation enables the radical-based retrosynthesis of seemingly trivial enantiopure dialkyl carbinols. The article discusses the history of such couplings, the retrosynthetic ramifications, general conditions development, and showcases various applications that demonstrate its simplification effect on synthesis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Copper-Catalyzed Coupling of Alkyl Vicinal Bis(boronic Esters) to an Array of Electrophiles

Ningxin Xu et al.

Summary: This study discovered that a neighboring boronate group in the substrate can accelerate transmetalation to copper, enabling site-selective cross-couplings of organoboronic esters. The method is practical and allows for coupling between vicinal bis(boronic esters) and allyl, alkynyl, propargyl electrophiles, and simple protons. Mechanistic experiments suggest the involvement of chelated cyclic ate complexes in transmetalation.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Multidisciplinary Sciences

Enantioselective synthesis of α-aminoboronates by NiH-catalysed asymmetric hydroamidation of alkenyl boronates

Yao Zhang et al.

Summary: In this study, a new synthetic method was reported for the highly enantioselective synthesis of chiral alpha-aminoboronates and their derivatives under mild conditions. The method was demonstrated to be efficient for the synthesis of a current pharmaceutical agent.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Multidisciplinary Sciences

Modular access to substituted cyclohexanes with kinetic stereocontrol

Yangyang Li et al.

Summary: In this study, we present a reliable and modular synthesis strategy for the excellent kinetic stereocontrol of disubstituted cyclohexanes from readily accessible substituted methylenecyclohexanes. By introducing a sterically demanding boron ester group adjacent to the cyclohexane, the stereochemical outcome can be guided. The synthetic potential of this method has been demonstrated in late-stage modification of complex bioactive molecules and compared with current cross-coupling techniques.

SCIENCE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides

Lianqian Wu et al.

Summary: An unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol% of a copper catalyst is reported. The use of a specific ligand is crucial for generating a monomeric Cu-II azide species for this highly enantioselective transformation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Enantioselective C(sp3)-C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis

Srikrishna Bera et al.

Summary: The enantioselective cross-coupling of non-activated alkyl halides with alkenyl boronates enables the synthesis of chiral alkyl boronates, which is a useful method for drug development. This reaction proceeds via nickel hydride insertion into an internal alkene followed by nickel-catalysed alkyl-alkyl cross-coupling.

NATURE CHEMISTRY (2021)

Add to Collection

Article Multidisciplinary Sciences

Enantioselective catalytic 1,2-boronate rearrangements

Hayden A. Sharma et al.

Summary: This study presents a strategy for constructing a wide variety of trisubstituted stereocenters through enantioselective, catalytic 1,2-boronate rearrangements. The chiral building blocks produced in these reactions can undergo two sequential stereospecific elaborations to generate a wide assortment of trisubstituted stereocenters. The enantioselective reaction is catalyzed by a lithium-isothiourea-boronate complex, which promotes rearrangement through a dual-lithium-induced chloride abstraction orchestrated by Lewis basic functionality on the catalyst scaffold.

SCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

Purui Zheng et al.

Summary: The authors reported a mild Ni/photoredox-catalyzed reductive cross-coupling of aryl iodides and alpha -chloroboranes, enriching the metallaphotoredox chemistry. This method enables the access to versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities under mild conditions.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A relay catalysis strategy for enantioselective nickel-catalyzed migratory hydroarylation forming chiral α-aryl alkylboronates

Yao Zhang et al.

Summary: By synergistically combining a known chain-walking ligand and a simple asymmetric cross-coupling ligand with the nickel catalyst, enantioen-riched alpha-aryl alkylboronates could be rapidly obtained as versatile synthetic intermediates through this formal asymmetric remote C(sp(3))-H arylation process.

CHEM (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Enantioselective Rh-Catalyzed Hydroboration of Silyl Enol Ethers

Wenke Dong et al.

Summary: Researchers reported a catalytic enantioselective hydroboration of silyl enol ethers (SEEs) using two new chiral phosphine ligands, featuring mild reaction conditions and a broad substrate scope.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Article Multidisciplinary Sciences

Enantioselective synthesis of tertiary boronic esters through catalytic asymmetric reversed hydroboration

Tao-Tao Gao et al.

Summary: The research team successfully synthesized chiral tertiary boronic esters through hydroboration, providing a method with high stereocontrol for inert Michael acceptors and potential applications in the synthesis of biologically active molecules.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Chemistry, Physical

α-Boryl Organometallic Reagents in Catalytic Asymmetric Synthesis

Chenlong Zhang et al.

Summary: In recent years, a-boryl organometallic reagents have become popular as versatile nucleophiles in asymmetric synthesis, enabling chemo- and stereoselective coupling reactions to produce enantioenriched boronic esters. This allows for efficient construction of complex structures with high functional group compatibility. Efforts have been focused on preparing enantiomerically enriched a-boryl organometallic reagents and developing stereoselective reactions of related racemic materials.

ACS CATALYSIS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Recent advances in asymmetric borylation by transition metal catalysis

Jiefeng Hu et al.

Summary: Researchers have devoted much effort in exploring synthetic methodologies for the preparation of chiral organoboronates. Among the known methods, asymmetric catalysis has emerged as a practical and highly efficient strategy for their straightforward preparation, with recent remarkable advances in approaches such as asymmetric borylative addition, asymmetric allylic borylation, and stereospecific cross-coupling borylation employing transition-metal catalysis with a chiral ligand.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Asymmetric organocatalysis: an enabling technology for medicinal chemistry

Bo Han et al.

Summary: Asymmetric organocatalysis has made significant contributions to organic synthesis since the early 2000s, especially in medicinal chemistry. This review provides a comprehensive overview of the specific applications of asymmetric organocatalysis in pharmaceutical synthesis, with a focus on the synthesis strategies of various bioactive molecules and their future prospects.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Aminoazanium of DABCO: An Amination Reagent for Alkyl and Aryl Pinacol Boronates

Xingxing Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Catalytic Enantioselective Synthesis of anti-Vicinal Silylboronates by Conjunctive Cross-Coupling

Yan Meng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Article Chemistry, Multidisciplinary

被撤回的出版物: Asymmetric Synthesis of α-Aminoboronates via Rhodium-Catalyzed Enantioselective C(sp3)-H Borylation (Retracted article. See vol. 144, pg. 10660, 2020)

Ronald L. Reyes et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Article Chemistry, Physical

Cascade CuH-catalysed conversion of alkynes into enantioenriched 1,1-disubstituted products

De-Wei Gao et al.

NATURE CATALYSIS (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Methodologies and Strategies for Selective Borylation of C-Het and C-C Bonds

Minyan Wang et al.

CHEMICAL REVIEWS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

Lili Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Review Chemistry, Physical

Copper-Catalyzed Borylative Difunctionalization of π-Systems

Andrew Whyte et al.

ACS CATALYSIS (2020)

Add to Collection

Article Chemistry, Physical

Catalyst-controlled enantioselective 1,1-arylboration of unactivated olefins

Wang Wang et al.

NATURE CATALYSIS (2020)

Add to Collection

Article Multidisciplinary Sciences

被撤回的出版物: Asymmetric remote C-H borylation of aliphatic amides and esters with a modular iridium catalyst (Retracted article. See vol. 376, pg. 468, 2022)

Ronald L. Reyes et al.

SCIENCE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Stereodivergent Synthesis through Catalytic Asymmetric Reversed Hydroboration

Tao-Tao Gao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Nickel-Catalyzed 1,1-Alkylboration of Electronically Unbiased Terminal Alkenes

Yangyang Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection

Article Chemistry, Multidisciplinary

被撤回的出版物: Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds (Retracted article. See vol. 144, pg. 10659, 2019)

Ronald L. Reyes et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Copper(I)-Catalyzed Enantioconvergent Borylation of Racemic Benzyl Chlorides Enabled by Quadrant-by-Quadrant Structure Modification of Chiral Bisphosphine Ligands

Hiroaki Iwamoto et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

Yongjia Shi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Helen A. Clement et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Rhodium-Catalyzed Regiodivergent and Enantioselective Hydroboration of Enamides

Xiao-Yan Bai et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Guanidine-Copper Complex Catalyzed Allylic Borylation for the Enantioconvergent Synthesis of Tertiary Cyclic Allylboronates

Yicen Ge et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection

Retraction Chemistry, Multidisciplinary

撤稿声明: Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds? (Retraction of Vol 141, Pg 6817, 2019)

Ronald L. Reyes et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Review Chemistry, Multidisciplinary

Reactions of organoboron compounds enabled by catalyst-promoted metalate shifts

Sheila Namirembe et al.

CHEMICAL SOCIETY REVIEWS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates

Ryoto Kojima et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Nickel-Catalyzed Enantioconvergent Borylation of Racemic Secondary Benzylic Electrophiles

Zhaobin Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection

Article Multidisciplinary Sciences

Asymmetric remote C-H borylation of internal alkenes via alkene isomerization

Xu Chen et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes

Pan Gao et al.

CHEM (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design

Jesse A. Myhill et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Article Chemistry, Organic

Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus

Santanu Jana et al.

ORGANIC LETTERS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Mechanistic Studies of Copper-Catalyzed Asymmetric Hydroboration of Alkenes

Yumeng Xi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Copper-Catalyzed Enantioselective Hydroboration of Unactivated 1,1-Disubstituted Alkenes

Won Jun Jang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Pd(II)-Catalyzed Enantioselective C(sp3)-H Borylation

Jian He et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl)borates: A General Synthesis of Chiral Allylboron Reagents

Emma K. Edelstein et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Pd-Catalyzed Conjunctive Cross -Coupling between Grignard-Derived Boron Ate Complexes and C(sp2) Halides or Triflates: NaOTf as a Grignard Activator and Halide Scavenger

Gabriel J. Lovinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy

Gabriel J. Lovinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection

Article Chemistry, Physical

Modular Synthesis of Enantioenriched 1,1,2-Triarylethanes by an Enantioselective Arylboration and Cross-Coupling Sequence

Bin Chen et al.

ACS CATALYSIS (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Nickel-Catalyzed Enantioselective Conjunctive Cross-Coupling of 9-BBN Borates

Matteo Chierchia et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection

Review Chemistry, Multidisciplinary

Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

Beatrice S. L. Collins et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Stereospecific functionalizations and transformations of secondary and tertiary boronic esters

Christopher Sandford et al.

CHEMICAL COMMUNICATIONS (2017)

Add to Collection

Article Multidisciplinary Sciences

Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement

Liang Zhang et al.

SCIENCE (2016)

Add to Collection

Review Chemistry, Multidisciplinary

Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes

John R. Coombs et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Add to Collection

Review Chemistry, Multidisciplinary

Synthesis of alpha-aminoboronic acids

Patricia Andres et al.

CHEMICAL SOCIETY REVIEWS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Accessing Both Retention and Inversion Pathways in Stereospecific, Nickel-Catalyzed Miyaura Borylations of Allylic Pivalates

Qi Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Add to Collection

Article Chemistry, Applied

A Biocatalytic Route to the Novel Antiepileptic Drug Brivaracetam

Arnaud Schule et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2016)

Add to Collection

Article Multidisciplinary Sciences

A general, modular method for the catalytic asymmetric synthesis of alkylboronate esters

Jens Schmidt et al.

SCIENCE (2016)

Add to Collection

Article Chemistry, Physical

Silver-Assisted, Iridium-Catalyzed Allylation of Bis[(pinacolato)boryl]methane Allows the Synthesis of Enantioenriched Homoallylic Organoboronic Esters

Miao Zhan et al.

ACS CATALYSIS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Stereospecific Coupling of Boronic Esters with N-Heteroaromatic Compounds

Josep Llaveria et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Ligand-Controlled Regiodivergent Cu-Catalyzed Aminoboration of Unactivated Terminal Alkenes

Ryosuke Sakae et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Add to Collection

Article Chemistry, Multidisciplinary

A Catalytic Enantiotopic-Group-Selective Suzuki Reaction for the Construction of Chiral Organoboronates

Chunrui Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Enantiospecific sp2-sp3 coupling of secondary and tertiary boronic esters

Amadeu Bonet et al.

NATURE CHEMISTRY (2014)

Add to Collection

Article Chemistry, Organic

Boronic Esters in Asymmetric Synthesis

Donald S. Matteson

JOURNAL OF ORGANIC CHEMISTRY (2013)

Add to Collection

Article Chemistry, Multidisciplinary

Highly Diastereo- and Enantioselective Allylboration of Aldehydes using α-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters

Jack L. -Y. Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Add to Collection

Review Chemistry, Multidisciplinary

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

Javier Magano et al.

CHEMICAL REVIEWS (2011)

Add to Collection

Article Chemistry, Applied

An Efficient Process for the Manufacture of Carmegliptin

Stefan Abrecht et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2011)

Add to Collection

Article Multidisciplinary Sciences

Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols

Jake L. Stymiest et al.

NATURE (2008)

Add to Collection

Article Chemistry, Organic

Enantiomerically pure synthesis of β-substituted γ-butyrolactones:: A key intermediate to concise synthesis of pregabalin

Taedong Ok et al.

JOURNAL OF ORGANIC CHEMISTRY (2007)

Add to Collection

Article Chemistry, Medicinal

Preparation of chiral 4-benzyloxymethyldihydrofuran-2-one using lipase-catalyzed kinetic resolution: Synthesis of (-)-virginiae butanolide C (VB C)

K Takabe et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.