4.8 Article

?Electron Transport Chain Interference? Strategy of Amplified Mild- Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Guiding Transition Metal-Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi-Enzymatic Activities for Intensive Chemodynamic Therapy

Shuming Dong et al.

Summary: The authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities to disrupt the H2O2 homeostasis, achieve intensive NCDT, and induce tumor apoptosis and death. The nanozyme catalyzes the conversion of superoxide anion into H2O2 in the tumor region and inhibits the off-target decomposition of H2O2. The elevated H2O2 is then converted into toxic hydroxyl radicals, leading to tumor cell death.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Zhan Zhou et al.

Summary: This study reports a biodegradable nanozyme based on layered MoO3 nanobelts for tumor-specific photo-enhanced catalytic therapy. The NH-MoO3-x nanobelts, obtained by intercalation with Na+ and H2O, exhibit excellent enzyme-mimicking catalytic activity and can be further enhanced by photothermal effect under 1064 nm laser irradiation, resulting in efficient killing of cancer cells and tumor elimination.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Materials Science, Multidisciplinary

Defect engineering in nanozymes

Yu Wu et al.

Summary: This review summarizes the defect engineering strategies in nanozymes and highlights the close relationships between defects and nanozyme properties. It is anticipated that defect engineering will bring new opportunities to the evolving field of nanozymes.

MATERIALS TODAY (2022)

Article Materials Science, Multidisciplinary

Innovative strategies to boost photothermal therapy at mild temperature mediated by functional nanomaterials

Yuanyuan Cao et al.

Summary: In recent years, there has been significant growth in the development of photothermal agents for photothermal therapy (PTT) in eradicating solid tumors. However, the effectiveness of PTT is hindered by challenges such as tumor thermotolerance, which can lead to inflammation, damage to normal organs, and tumor recurrence. This review explores innovative strategies to enhance PTT at mild temperatures, focusing on the apoptotic pathway. It also discusses recent advances in regulating heat shock proteins expression, autophagy level, free radical generation, and organelle targeting to overcome tumor thermotolerance, as well as combining mild-temperature PTT with other therapies for a superadditive effect. The review concludes with a discussion on the scientific and technical challenges of mild-temperature PTT for clinical translation.

MATERIALS & DESIGN (2022)

Article Nanoscience & Nanotechnology

A Platelet-Mimicking Single-Atom Nanozyme for Mitochondrial Damage-Mediated Mild-Temperature Photothermal Therapy

Pengyuan Qi et al.

Summary: In this study, a novel platelet membrane-coated mesoporous Fe single-atom nanozyme (PMS) was developed for efficient tumor therapy. The PMS showed satisfactory NIR-II photothermal performance, high peroxidase activity, good tumor-targeting ability, and the ability to serve as a carrier for protein drugs. In vitro and in vivo experiments demonstrated the PMS's ability to inhibit HSP expression and effectively accumulate in tumor sites without causing significant toxicity in major organs. This study provides a new promising approach for cancer treatment using biomimetic mesoporous Fe single-atom nanozymes.

ACS APPLIED MATERIALS & INTERFACES (2022)

Review Chemistry, Inorganic & Nuclear

Low temperature photothermal therapy: Advances and perspectives

Ke Yang et al.

Summary: Photothermal therapy (PTT) is attracting increasing attention due to its high selectivity, non-invasiveness, negligible drug resistance, oxygen independence, and minimal side effects. However, there are still challenges in its clinical application, such as effectively eliminating tumors without damaging surrounding normal tissues, and overcoming cell tolerance to heat.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Inhibition of NADP(H) supply by highly active phosphatase-like ceria nanozymes to boost oxidative stress and ferroptosis

Y. Xiong et al.

Summary: A phosphatase-mimicking nanozyme CeO2 with ultra-small structure and excellent dispersibility has been successfully synthesized, which can effectively dephosphorylate NADP(H) and inhibit the biosynthesis of GSH in non-redox biological applications.

MATERIALS TODAY CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

H2O2-Responsive NIR-II AIE Nanobomb for Carbon Monoxide Boosting Low-Temperature Photothermal Therapy

Gongcheng Ma et al.

Summary: Low-temperature photothermal therapy (PTT) is a promising therapeutic strategy, but the expression of heat shock proteins (HSPs) can hinder its efficacy. Researchers have developed a smart nanobomb that can explode in the tumor microenvironment and release carbon monoxide (CO) to inhibit the expression of HSPs, thereby improving the effectiveness of low-temperature PTT.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Review Chemistry, Physical

Insights on catalytic mechanism of CeO2 as multiple nanozymes

Yuanyuan Ma et al.

Summary: CeO2 nanozymes with tailorable surface physicochemical properties exhibit diverse catalytic behaviors under different conditions, showing potential for disease diagnosis and treatments.

NANO RESEARCH (2022)

Review Chemistry, Multidisciplinary

Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics

Si Si Liew et al.

Summary: This review summarizes recent developments and strategies in the smart design of nanocarriers for mitochondria-targeted therapeutics, including subcellular targeting, stimuli-responsive nanocarriers, and synergistic therapy, while also discussing existing challenges and unexplored therapeutic opportunities.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Biotechnology & Applied Microbiology

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui et al.

Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.

NATURE BIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers

Yue Zhang et al.

Summary: Integrating protein reconstruction technology and nanotechnology, an artificial hybrid nanozyme with superoxide dismutase and catalase-like activities was developed to target mitochondria and demonstrate protective effects in mitochondrial oxidative injury and heart function recovery. This innovative approach highlights the potential of enzyme mimics in regenerative medicine for alleviating oxidative damage.

ADVANCED MATERIALS (2021)

Article Chemistry, Physical

NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing

Chuang Liu et al.

Summary: By constructing a dumbbell-shaped Au@CeO2 hybrid nanozyme with strong surface plasmon resonance response in the Near Infrared (NIR) range, the peroxidase-like activity of Au@CeO2 was significantly enhanced under 808 nm irradiation. The efficient utilization of plasmon excitation through spatially separated structure led to improved antibacterial efficacy.

APPLIED CATALYSIS B-ENVIRONMENTAL (2021)

Article Pharmacology & Pharmacy

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis

Zi-Xuan Wang et al.

Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Chemistry, Multidisciplinary

Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Xiangyu Deng et al.

Summary: Phototherapy, such as photothermal therapy and photodynamic therapy, has shown great potential in cancer treatment, but there are still many challenges that need to be addressed. Scientists are designing different systems to overcome the drawbacks associated with phototherapy, aiming to make it a more effective cancer treatment approach in clinical practice. This article discusses the problems and solutions in phototherapy research, providing insights for future advancements in the field.

ADVANCED SCIENCE (2021)

Review Chemistry, Multidisciplinary

Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment

Ge Gao et al.

Summary: Photothermal therapy (PTT) has emerged as a promising anticancer strategy, with mild-temperature PTT showing great potential. However, the therapeutic efficacy of mild-temperature PTT is limited by its lower heat intensity, necessitating strategies to enhance its anticancer effects.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Single-Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy

Mengyu Chang et al.

Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Multidisciplinary Sciences

Low-Temperature Photothermal Therapy: Strategies and Applications

Xiulin Yi et al.

Summary: This study summarises strategies for achieving low-temperature PTT using nanomaterials, introduces the synthesis, characteristics, and applications of these nanoplatforms, and discusses the synergistic cancer therapeutic effect of combining PTT with other treatment modalities.

RESEARCH (2021)

Article Nanoscience & Nanotechnology

Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells

Pei Wang et al.

Summary: Researchers have developed a nanosystem for mild-temperature photothermal therapy by using modified nanoparticles, achieving efficient treatment of cancer cells by disrupting ATP production. This innovative approach shows significant potential for various biomedical applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Intracellular Nanoparticle Formation and Hydroxychloroquine Release for Autophagy-Inhibited Mild-Temperature Photothermal Therapy for Tumors

Ge Gao et al.

Summary: Through rational design of a peptide-hydroxychloroquine conjugate, a smart strategy involving enzyme-triggered intracellular nanoparticle formation and HCQ release is proposed for autophagy-inhibited mild-temperature photothermal therapy of tumors. In vitro results demonstrate the conversion of the conjugate to a self-assembling nanoparticle and release of HCQ under dual enzyme catalysis, leading to exceptional therapeutic effects in vivo via intracellular nanoparticle formation and autophagy inhibition.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy

Bin Yu et al.

Summary: This study demonstrates the development of a simple yet efficient redox nanozyme through defect engineering, which enhances binding capacity and catalytic activity, leading to substantial disruption of redox and metabolism homeostasis in the tumor region.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Multidisciplinary Sciences

A nonferrous ferroptosis-like strategy for antioxidant inhibition-synergized nanocatalytic tumor therapeutics

Chenyao Wu et al.

Summary: This study introduces a non-ferrous ferroptosis-like strategy based on a hybrid CoMoO4-phosphomolybdic acid nanosheet (CPMNS), which achieves efficient anticancer efficacy through specific mechanisms. The high feasibility of this approach in nanocatalytic medicine is expected to advance cancer therapeutic regimens in the future.

SCIENCE ADVANCES (2021)

Article Chemistry, Multidisciplinary

A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy

Xinyue Cui et al.

Summary: This study demonstrated the construction of a nanodiamond-based nanoplatform for enhanced mild-temperature photothermal/chemo combination therapy against TNBC by inhibiting autophagy, which could weaken therapeutic resistance and improve anti-tumor efficacy both in vitro and in vivo. Additionally, the nanoplatform could be used for fluorescence and photoacoustic imaging, showing its potential as a theranostic tool.

NANOSCALE (2021)

Review Chemistry, Multidisciplinary

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Yuxuan Xiong et al.

Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.

CHEMICAL SOCIETY REVIEWS (2021)

Review Pharmacology & Pharmacy

Inorganic Nanomaterials for Photothermal-Based Cancer Theranostics

Huang Wen et al.

Summary: This review article first summarizes the methods for synthesizing inorganic photothermal agents and their in vitro and in vivo evaluations, followed by a description of a clinical trial using an inorganic PTA. The final part of the review examines the challenges and possibilities for successful translation of inorganic PTAs from the laboratory to the clinic.

ADVANCED THERAPEUTICS (2021)

Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy

Ge Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Yanjuan Sang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Cell Biology

Ferroptosis and Cancer: Mitochondria Meet the Iron Maiden Cell Death

Anna Martina Battaglia et al.

CELLS (2020)

Article Chemistry, Multidisciplinary

Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

Canchen Wu et al.

CHEMICAL COMMUNICATIONS (2020)

Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

Article Nanoscience & Nanotechnology

Phosphatase-like Activity of Porous Nanorods of CeO2 for the Highly Stabilized Dephosphorylation under Interferences

Tianzhu Yao et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Chemistry, Multidisciplinary

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Qinrui Fu et al.

ADVANCED MATERIALS (2019)

Article Chemistry, Multidisciplinary

Nanocatalytic Tumor Therapy by Single-Atom Catalysts

Minfeng Huo et al.

ACS NANO (2019)

Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Biochemical Research Methods

Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes

Bing Jiang et al.

NATURE PROTOCOLS (2018)

Article Multidisciplinary Sciences

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Hai Wang et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases

Ambika Bhagi-Damodaran et al.

NATURE CHEMISTRY (2017)

Article Multidisciplinary Sciences

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

Qian Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy

Yu Yang et al.

ADVANCED MATERIALS (2017)

Article Chemistry, Multidisciplinary

Ceria-Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Min Soh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Materials Science, Biomaterials

Fe-doped CeO2 nanorods for enhanced peroxidase-like activity and their application towards glucose detection

Deshetti Jampaiah et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Article Chemistry, Physical

Nanostructured manganese doped ceria solid solutions for CO oxidation at lower temperatures

Perala Venkataswamy et al.

APPLIED CATALYSIS B-ENVIRONMENTAL (2015)

Article Biochemistry & Molecular Biology

Targeting mitochondria metabolism for cancer therapy

Samuel E. Weinberg et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Chemistry, Physical

Fe-doped ceria solids synthesized by the microemulsion method for CO oxidation reactions

O. H. Laguna et al.

APPLIED CATALYSIS B-ENVIRONMENTAL (2011)

Article Chemistry, Physical

Computational Investigation of CO Adsorption and Oxidation on Iron-Modified Cerium Oxide

Hsin-Tsung Chen et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2011)

Article Chemistry, Multidisciplinary

Cell-Specific, Activatable, and Theranostic Prodrug for Dual-Targeted Cancer Imaging and Therapy

Santimukul Santra et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Cell Biology

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

Mikko Taipale et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Engineering, Biomedical

The role of cerium redox state in the SOD mimetic activity of nanoceria

Eric G. Heckert et al.

BIOMATERIALS (2008)