Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 14, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12967-016-0982-x
Keywords
Berberine; Nonalcoholic fatty liver disease; Lipidomic approach; Sphingolipids; Ceramide
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Funding
- National Key Basic Research Program of China [2012CB524906]
- Shanghai Municipal Health Project grant [2013ZYJB0802]
- Shanghai Health and Family Planning Commission Foundation [12GWZX0103, 2013SY005]
- Science and Technology Commission of Shanghai Municipality [13441900303]
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Background: We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berberine treatment, which decreased the content of hepatic fat. However, the potential mechanisms of the clinical effects are unclear. We used a lipidomic approach to characterize the state of lipid metabolism as reflected in the circulation of subjects with nonalcoholic fatty liver disease (NAFLD) before and after berberine treatment. Methods: Liquid chromatography-mass spectrometry evaluated the various lipid metabolites in serum samples obtained from the participants (41 patients in the berberine group and 39 patients in the mere lifestyle intervention group) before and after treatment. Results: A total of 256 serum lipid molecular species were identified and quantified. Both treatments regulated various types of lipids in metabolic pathways, such as free fatty acids, phosphoglycerides and glycerides, in metabolic pathways, but berberine induced a substantially greater change in serum lipid species compared with mere lifestyle intervention after treatment. Berberine also caused obvious differences on ceramides. Berberine treatment markedly decreased serum levels of ceramide and ceramide-1-phosphate. Conclusions: Berberine altered circulating ceramides, which may underlie the improvement in fatty liver disease.
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