4.7 Article

Bridging the gap to therapeutic strategies based on connexin/pannexin biology

Journal

JOURNAL OF TRANSLATIONAL MEDICINE
Volume 14, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/s12967-016-1089-0

Keywords

Gap junctions; Connexins; Pannexins; Therapeutics; Peptides; Strategies

Funding

  1. Foundation Hugot of the College de France
  2. Consulat General de France in Vancouver
  3. Zealand Pharma
  4. FirstString Research
  5. Theranexus
  6. Brain Canada
  7. Michael Smith Foundation for Health Research
  8. Genome BC
  9. Pacific Alzheimer's Research Foundation

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A unique workshop was recently held focusing on enhancing collaborations leading to identify and update the development of therapeutic strategies targeting connexin/pannexin large pore channels. Basic scientists exploring the functions of these channels in various pathologies gathered together with leading pharma companies which are targeting gap junction proteins for specific therapeutic applications. This highlights how paths of discovery research can converge with therapeutic strategies in innovative ways to enhance target identification and validation.

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