RNA analysis of tape strips to rule out melanoma in lesions clinically assessed as cutaneous malignant melanoma: A diagnostic study

Article Cell Biology

PRAME is a useful marker for the differential diagnosis of melanocytic tumours and histological mimics

Yan-Ping Chen et al.

Summary: The study suggests that PRAME may be a useful marker for supporting the diagnosis of melanoma and lack of PRAME expression may indicate clear cell sarcoma (CCS) in suspected cases.

HISTOPATHOLOGY (2023)

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Review Oncology

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022

Claus Garbe et al.

Summary: This study provides recommendations for the diagnosis and treatment of cutaneous melanoma (CM) based on systematic literature reviews and the experts' experience. The study emphasizes the importance of clinical and dermatoscopic examination for the diagnosis of melanoma, followed by histopathological confirmation. Imaging diagnostics such as sequential digital dermatoscopy and full body photography are suggested for high-risk patients to improve early melanoma detection. The study also provides guidelines for classification, staging, and follow-up schemes, as well as the use of imaging examinations in different stages.

EUROPEAN JOURNAL OF CANCER (2022)

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Article Pathology

PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors

Maciej Kaczorowski et al.

Summary: Preferentially expressed antigen in melanoma (PRAME) is a useful marker in distinguishing malignant melanoma from its mimics. This study found that PRAME is variably expressed in different types of malignancies, but it is strongly expressed in nonmelanocytic poorly differentiated carcinomas and sarcomas. Although the use of PRAME as an immunohistochemical marker in diagnostic surgical pathology is limited, immunohistochemistry is reliable and cost-effective for detecting PRAME-positive malignancies for potential immunotherapy.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2022)

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Article Multidisciplinary Sciences

Detection of cutaneous malignant melanoma using RNA sampled by tape strips: A study protocol

Ida M. Heerfordt et al.

Summary: This study aims to use RNA analysis to improve early diagnostic accuracy of suspicious lesions and enhance the management of CMM.

PLOS ONE (2022)

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Letter Dermatology

Decreased public awareness of skin cancer during the coronavirus pandemic

Ida M. Heerfordt

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Preferentially expressed antigen in melanoma expression in nonmelanoma skin cancers and melanocytes in surrounding skin

Ashley Elsensohn et al.

Summary: PRAME expression is generally low in nonmelanoma skin cancers, with exceptions in some Merkel cell carcinomas showing high-intensity staining. Focal DEJ melanocytes surrounding some nonmelanoma skin cancers exhibit high-intensity PRAME reactivity.

JOURNAL OF CUTANEOUS PATHOLOGY (2021)

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Letter Dermatology

Real-World Application of a Noninvasive Two-Gene Expression Test for Melanoma Diagnosis

Michael A. Marchetti et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Multidisciplinary Sciences

Impact of the COVID-19 pandemic on skin cancer diagnosis: A population-based study

Yuka Asai et al.

Summary: During the early stages of the COVID-19 pandemic, there was a significant decrease in skin biopsy rates, especially affecting the elderly, females, and residents of specific geographic regions. Although biopsy rates eventually increased, a backlog of cases remained almost half a year later.

PLOS ONE (2021)

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Article Dermatology